The tyrosine kinase inhibitor Nintedanib induces lysosomal dysfunctionality: Role of protonation-dependent crystallization processes.

Autor: Mosca E; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Federa A; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria; Doctoral School in Chemistry (DoSChem), University of Vienna, Währinger Straße 40-42, 1090, Vienna, Austria., Pirker C; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Schosserer M; Center of Pathobiochemistry and Genetics, Medical University of Vienna, Währinger Straße 10, 1090, Vienna, Austria., Liendl L; Institute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, 1190, Vienna, Austria., Eckhard M; Center for Anatomy and Cell Biology, Cell and Developmental Biology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria., Sombke A; Center for Anatomy and Cell Biology, Cell and Developmental Biology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090, Vienna, Austria., Dömötör O; Department of Molecular and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, H-6720, Dóm Tér 7-8, Szeged, Hungary., Kirchhofer D; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Timelthaler G; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria., Baier D; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria; Research Cluster 'Translational Cancer Therapy Research', Vienna, 1090, Austria., Gurschka P; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria; Department of Neurosurgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria., Gabler L; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria; Department of Neurosurgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria., Reithofer M; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria., Chin JM; Department of Functional Materials and Catalysis, Währinger Straße 42, 1090, Vienna, Austria., Elsayad K; Division of Anatomy, Center of Anatomy and Cell Biology, Medical University of Vienna, Währinger Straße 13, 1090, Vienna, Austria., Englinger B; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria; Department of Urology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria., Tahir A; Division of Pharmacognosy, Department of Pharmaceutical Sciences, Faculty of Life Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090, Vienna, Austria; Section of Biomedical Sciences, Department of Health Sciences, FH Campus Wien, University of Applied Sciences, Favoritenstraße 226, 1100, Vienna, Austria., Kowol CR; Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, 1090, Vienna, Austria. Electronic address: christian.kowol@univie.ac.at., Berger W; Center of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria. Electronic address: walter.berger@meduniwien.ac.at.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2024 Nov 01; Vol. 403, pp. 111243. Date of Electronic Publication: 2024 Sep 14.

T-cell subset changes during the first year of pre-seasonal allergoid allergen-specific immunotherapy.

Autor: Reithofer M; Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.; Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria., Boell SL; Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria., Kitzmueller C; Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria., Horak F; Allergiezentrum Wien West, Vienna, Austria., Bohle B; Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria., Jahn-Schmid B; Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

Publikováno v: Heliyon [Heliyon] 2023 Nov 10; Vol. 9 (11), pp. e21878. Date of Electronic Publication: 2023 Nov 10 (Print Publication: 2023).

A Biomimetic, Silaffin R5-Based Antigen Delivery Platform.

Autor: Reichinger D; Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 38, 1090 Vienna, Austria.; Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, Währinger Str. 42, 1090 Vienna, Austria., Reithofer M; Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.; Institute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences, Gregor-Mendel-Straße 33, 1180 Vienna, Austria., Hohagen M; Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, Währinger Str. 42, 1090 Vienna, Austria.; Department of Inorganic Chemistry-Functional Materials, Faculty of Chemistry, University of Vienna, Währinger Str. 42, 1090 Vienna, Austria., Drinic M; Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, Austria., Tobias J; Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, Austria., Wiedermann U; Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, Austria., Kleitz F; Department of Inorganic Chemistry-Functional Materials, Faculty of Chemistry, University of Vienna, Währinger Str. 42, 1090 Vienna, Austria., Jahn-Schmid B; Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria., Becker CFW; Institute of Biological Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 38, 1090 Vienna, Austria.

Publikováno v: Pharmaceutics [Pharmaceutics] 2022 Dec 29; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 29.

Amb a 1 isoforms: Unequal siblings with distinct immunological features

Autor: Wolf, M., Twaroch, T. E., Huber, S., Reithofer, M., Steiner, M., Aglas, L., Hauser, M., Aloisi, I., Asam, C., Hofer, H., Parigiani, M. A., Ebner, C., Bohle, B., Briza, P., Neubauer, A., Stolz, F., Jahn-Schmid, B., Wallner, M., Ferreira, F.

Publikováno v: Allergy

Background Ragweed pollen represents a major allergy risk factor. Ragweed extracts contain five different isoforms of the major allergen Amb a 1. However, the immunological characteristics of Amb a 1 isoforms are not fully investigated. Here, we comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6d05be4fa006c1130701ae66eacded36
https://pubmed.ncbi.nlm.nih.gov/28464293

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