Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7.

Autor: Swain NA, Batchelor D, Beaudoin S; Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States., Bechle BM; Worldwide Medicinal Chemistry, Pfizer Inc. , Eastern Point Road, Groton, Connecticut 06340, United States., Bradley PA, Brown AD, Brown B, Butcher KJ, Butt RP, Chapman ML; Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States., Denton S, Ellis D, Galan SRG, Gaulier SM, Greener BS, de Groot MJ, Glossop MS, Gurrell IK, Hannam J, Johnson MS; Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States., Lin Z; Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States., Markworth CJ; Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States., Marron BE; Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States., Millan DS, Nakagawa S, Pike A, Printzenhoff D; Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States., Rawson DJ, Ransley SJ, Reister SM; Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States., Sasaki K, Storer RI, Stupple PA, West CW; Icagen Inc. , 4222 Emperor Blvd no. 350, Durham, North Carolina 27703, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Aug 24; Vol. 60 (16), pp. 7029-7042. Date of Electronic Publication: 2017 Aug 10.