The scaffolding protein IQGAP1 enhances EGFR signaling by promoting oligomerization and preventing degradation.

Autor: Yerramilli VS; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA., Lin G; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA., Reisinger JL; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA., Hemmerlin RM; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA., Lindberg SK; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA., Plante K; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA., Ross AH; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Gericke A; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA., Scarlata S; Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, Massachusetts, USA. Electronic address: sfscarlata@wpi.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 Nov; Vol. 300 (11), pp. 107844. Date of Electronic Publication: 2024 Sep 30.