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Akademický článek

Transcriptional Dysregulation and Impaired Neuronal Activity in FMR1 Knock-Out and Fragile X Patients' iPSC-Derived Models.

Autor: Maussion G; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Rocha C; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Abdian N; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Yang D; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Turk J; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Carrillo Valenzuela D; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Pimentel L; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., You Z; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Morquette B; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Nicouleau M; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Deneault E; Regulatory Research Division, Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON K1A 0K9, Canada., Higgins S; Roche Sequencing, Computational Science and Informatics, Roche Molecular Systems, Santa Clara, CA 95050, USA., Chen CX; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Reintsch WE; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Ho S; Research and Early Development, Roche Molecular Systems, Pleasanton, CA 94588, USA., Soubannier V; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada., Lépine S; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada.; Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 2M1, Canada., Modrusan Z; Genentech, South San Francisco, CA 94080, USA., Lund J; Genentech, South San Francisco, CA 94080, USA., Stephenson W; Genentech, South San Francisco, CA 94080, USA., Schubert R; Research and Early Development, Roche Molecular Systems, Pleasanton, CA 94588, USA., Durcan TM; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, Montreal, QC H3A 2B4, Canada.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 05; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 05.

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Akademický článek

An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids.

Autor: Castellanos-Montiel MJ; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Chaineau M; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Franco-Flores AK; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Haghi G; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Carrillo-Valenzuela D; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Reintsch WE; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Chen CX; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Durcan TM; The Neuro's Early Drug Discovery Unit (EDDU), McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada.

Publikováno v: Cells [Cells] 2023 Feb 08; Vol. 12 (4). Date of Electronic Publication: 2023 Feb 08.

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Akademický článek

Rapid macropinocytic transfer of α-synuclein to lysosomes.

Autor: Bayati A; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Banks E; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Han C; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Luo W; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Reintsch WE; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Zorca CE; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Shlaifer I; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Del Cid Pellitero E; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Vanderperre B; Department of Biological Sciences, Université du Québec à Montréal, Montreal, QC, Canada., McBride HM; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Fon EA; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., Durcan TM; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada., McPherson PS; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada. Electronic address: peter.mcpherson@mcgill.ca.

Publikováno v: Cell reports [Cell Rep] 2022 Jul 19; Vol. 40 (3), pp. 111102.

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Akademický článek

HT-COMET: a novel automated approach for high throughput assessment of human sperm chromatin quality.

Autor: Albert O; Department of Pharmacology &Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada., Reintsch WE; Department of Pharmacology & Therapeutics, McGill University, Green Chemistry CFI Platform, Montreal, QC, H3G 1Y6, Canada., Chan P; Department of Urology, McGill University Health Centre, Montreal, QC, H4A 3J1, Canada., Robaire B; Department of Pharmacology &Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada Department of Obstetrics & Gynecology, McGill University, Montreal, QC, H4A 3J1, Canada bernard.robaire@mcgill.ca.

Publikováno v: Human reproduction (Oxford, England) [Hum Reprod] 2016 May; Vol. 31 (5), pp. 938-46. Date of Electronic Publication: 2016 Mar 13.

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