Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Reinoud, Gosens"'
Autor:
Dan Li, Rosa K. Kortekaas, Kelly B.I. Douglas, Wanda Douwenga, Ulrich L.M. Eisel, Barbro N. Melgert, Reinoud Gosens, Martina Schmidt
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 181, Iss , Pp 117704- (2024)
Bacterial respiratory infections are a major global health concern, often leading to lung injury and triggering lung repair mechanisms. Endogenous epithelial progenitor cells are crucial in this repair, yet the mechanisms remain poorly understood. Th
Externí odkaz:
https://doaj.org/article/d40cc52ce7c640ef8d503d35caeb9a29
Autor:
Rosa K. Kortekaas, Kerstin E. Geillinger-Kästle, Rocío Fuentes-Mateos, Roël van Orsoy, Nakaa Al-Alyan, Janette K. Burgess, Reinoud Gosens
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionExacerbations of chronic obstructive pulmonary disease (COPD) increase mortality risk and can lead to accelerated loss of lung function. The increased inflammatory response during exacerbations contributes to worsening of airflow limitati
Externí odkaz:
https://doaj.org/article/f490fd823a3d4df79534252d7f20c695
Autor:
Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen, Chris Brightling, Alberto Papi, Klaus F. Rabe, Salman Siddiqui, Dave Singh, Monica Kraft, Bianca Beghe, Maarten van den Berge, Djoke van Gosliga, Martijn C. Nawijn, Stefan Rose-John, Gerard H. Koppelman, Reinoud Gosens
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that target type 2-low inflammation. Previous studies have linked IL-6 signaling to severe asthma.
Externí odkaz:
https://doaj.org/article/e4d93162eadc447d86daca4b0d26e0df
Autor:
Daiana Stolz, Maria Gabriella Matera, Paola Rogliani, Maarten van den Berge, Eleni Papakonstantinou, Reinoud Gosens, Dave Singh, Nicola Hanania, Mario Cazzola, Anke-Hilse Maitland-van der Zee, Laura Fregonese, Alexander G. Mathioudakis, Jørgen Vestbo, Maia Rukhadze, Clive P. Page
Publikováno v:
Breathe, Vol 19, Iss 2 (2023)
Pharmacological management of airway obstructive diseases is a fast-evolving field. Several advances in unravelling disease mechanisms as well as intracellular and molecular pathways of drug action have been accomplished. While the clinical translati
Externí odkaz:
https://doaj.org/article/d318550bc22949b8b4e3a6be9a3c1560
Autor:
Siti Farah Rahmawati, Rémon Vos, I. Sophie T. Bos, Huib A. M. Kerstjens, Loes E. M. Kistemaker, Reinoud Gosens
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Asthmatics have elevated levels of IL-17A compared to healthy controls. IL-17A is likely to contribute to reduced corticosteroid sensitivity of human airway epithelium. Here, we aimed to investigate the mechanistic underpinnings of this redu
Externí odkaz:
https://doaj.org/article/743b1d96993347b7928470e65d4f95bf
Autor:
Rosa K. Kortekaas, Kerstin E. Geillinger-Kästle, Theo Borghuis, Kaoutar Belharch, Megan Webster, Wim Timens, Janette K. Burgess, Reinoud Gosens
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Background Interleukin-11 (IL-11) is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF), since IL-11 induces myofibroblast differentiation and stimulates their excessive collagen deposition in the lung. In IPF there is disrupted alveol
Externí odkaz:
https://doaj.org/article/a8b885525ab44cb0b4fa31e6171fa9e5
Autor:
Zaid W. El‐Husseini, Judith M. Vonk, Maarten van denBerge, Reinoud Gosens, Gerard H. Koppelman
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction Asthma is a complex, polygenic, heterogenous inflammatory disease. Recently, we generated a list of 128 independent single nucleotide polymorphisms (SNPs) associated with asthma in genome‐wide association studies. However, it
Externí odkaz:
https://doaj.org/article/0e8cd52efa0443b49dbf35e43a6d9863
Autor:
Karthi Srikanthan, Loes Kistemaker, Dirk-Jan Slebos, Wolfgang Gesierich, Kaid Darwiche, Peter Bonta, Gaetan Deslee, Pallav Shah, Reinoud Gosens
Publikováno v:
ERJ Open Research, Vol 8, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/7030bdb8c4c34dda8b3c9d84e1b5d2b2
Autor:
Mariska P. M. van den Berg, Susan Nijboer-Brinksma, I. Sophie T. Bos, Maarten van den Berge, David Lamb, Martijn van Faassen, Ido P. Kema, Reinoud Gosens, Loes E. M. Kistemaker
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract Background Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor Potential Ankyrin 1 (TRPA1) channels, contributes to asthma characteristics
Externí odkaz:
https://doaj.org/article/390589a8cf6b4bccb3ab15de0bce3098
Autor:
Siti Farah Rahmawati, Maurice te Velde, Huib A. M. Kerstjens, Alexander S. S. Dömling, Matthew Robert Groves, Reinoud Gosens
Publikováno v:
Frontiers in Allergy, Vol 2 (2021)
Asthma is a respiratory disease that currently affects around 300 million people worldwide and is defined by coughing, shortness of breath, wheezing, mucus overproduction, chest tightness, and expiratory airflow limitation. Increased levels of interl
Externí odkaz:
https://doaj.org/article/e12b3d274c85448f971aeb378a199210