OnPLS-Based Multi-Block Data Integration : A Multivariate Approach to Interrogating Biological Interactions in Asthma

Autor: Reinke, SN, Galindo-Prieto, B, Skotare, T, Broadhurst, DI, Singhania, A, Horowitz, D, Djukanovic, R, Hinks, TSC, Geladi, P, Trygg, J, Wheelock, CE

Publikováno v: Analytical Chemistry

Integration of multiomics data remains a key challenge in fulfilling the potential of comprehensive systems biology. Multiple-block orthogonal projections to latent structures (OnPLS) is a Multi projection method that simultaneously models multiple d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1c03cc1082f92a6bd88b91bf460b97f4
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154351

Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis.

Autor: Reinke, SN, Broadhurst, DI, Sykes, BD, Baker, GB, Catz, I, Warren, KG, Power, C

Publikováno v: Multiple Sclerosis Journal; Sep2014, Vol. 20 Issue 10, p1396-1400, 5p, 1 Chart, 1 Graph

Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma.

Autor: Mendez KM; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Perth, Australia., Begum S; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Tiwari A; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Sharma R; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chen Q; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Kelly RS; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Prince N; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Huang M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Kachroo P; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chu SH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chen Y; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Lee-Sarwar K; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Broadhurst DI; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Perth, Australia., Reinke SN; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Perth, Australia., Gerszten R; Department of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Clish C; Broad Institute, Cambridge, MA, USA., Avila L; Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA., Celedón JC; Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA., Wheelock CE; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Weiss ST; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., McGeachie M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Lasky-Su JA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: rejas@channing.harvard.edu.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Apr; Vol. 102, pp. 105025. Date of Electronic Publication: 2024 Mar 07.

Metabolomics reveals mouse plasma metabolite responses to acute exercise and effects of disrupting AMPK-glycogen interactions.

Autor: Belhaj MR; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia., Lawler NG; Centre for Integrative Metabolomics and Computational Biology, School of Science, Edith Cowan University, Joondalup, WA, Australia.; Australian National Phenome Centre and Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA, Australia., Hawley JA; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia., Broadhurst DI; Centre for Integrative Metabolomics and Computational Biology, School of Science, Edith Cowan University, Joondalup, WA, Australia., Hoffman NJ; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia., Reinke SN; Centre for Integrative Metabolomics and Computational Biology, School of Science, Edith Cowan University, Joondalup, WA, Australia.

Publikováno v: Frontiers in molecular biosciences [Front Mol Biosci] 2022 Aug 24; Vol. 9, pp. 957549. Date of Electronic Publication: 2022 Aug 24 (Print Publication: 2022).

Lipopolysaccharide-induced interferon response networks at birth are predictive of severe viral lower respiratory infections in the first year of life.

Autor: Read JF; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; School of Medicine, The University of Western Australia, Nedlands, WA, Australia., Serralha M; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia., Mok D; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia., Holt BJ; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia., Cruickshank M; School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia., Karpievitch YV; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia., Broadhurst DI; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Joondalup, WA, Australia., Sly PD; Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia., Strickland DH; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; The University of Western Australia Centre for Child Health Research, The University of Western Australia, Nedlands, WA, Australia., Reinke SN; Centre for Integrative Metabolomics & Computational Biology, School of Science, Edith Cowan University, Joondalup, WA, Australia., Holt PG; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; The University of Western Australia Centre for Child Health Research, The University of Western Australia, Nedlands, WA, Australia., Bosco A; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.; The University of Western Australia Centre for Child Health Research, The University of Western Australia, Nedlands, WA, Australia.; Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, United States.; Department of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Aug 05; Vol. 13, pp. 876654. Date of Electronic Publication: 2022 Aug 05 (Print Publication: 2022).