Výsledky vyhledávání - "Reinhold, Altmann"

The Interleukin 1 (IL-1) Receptor Accessory Protein Toll/IL-1 Receptor Domain

Autor: Michael U. Martin, Detlef Neumann, Werner Falk, Jürgen Radons, Stefan Dove, Reinhold Altmann, Alexander Botzki

Publikováno v: Journal of Biological Chemistry. 278:49145-49153

The Toll/interleukin 1 (IL-1) receptor family plays an important role in both innate and adaptive immunity. These receptors are characterized by a C-terminal homology motif called the Toll/IL-1 receptor (TIR) domain. A principal function of the TIR d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd64c411d493d54964d17c2c4dc12ae8
https://doi.org/10.1074/jbc.m306077200

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2-Arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 1. Structure–activity relationships of the terminal aryl ring

Autor: Reinhold Altmann, Helge Prinz, Klaus Müller

Publikováno v: European Journal of Medicinal Chemistry. 36:569-575

A series of 2-arylmethyl-substituted anthracenones were synthesized and tested as inhibitors of three types of 12-lipoxygenase isoforms in epidermal homogenate of mice, bovine platelets and porcine leucocytes. Their inhibitory activities were compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bc495afb0db690ea1e565b5cf3fbcc
https://doi.org/10.1016/s0223-5234(01)01248-x

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10-Benzoyl-1,8-dihydroxy-9(10H)-anthracenones: Synthesis and biological properties

Autor: Helge Prinz, Reinhold Altmann, Klaus Müller

Publikováno v: European Journal of Medicinal Chemistry. 33:209-214

The synthesis and biological properties of 10-benzoyl-1,8-dihydroxy-9(10H)-anthracenones are described. The compounds were evaluated for their ability to inhibit the growth of the human keratinocyte cell line HaCaT and the 5-lipoxygenase enzyme in bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30b7aa2c29884a0e3ae57e2220fa7ec7
https://doi.org/10.1016/s0223-5234(98)80010-x

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ChemInform Abstract: 10-Benzoyl-1,8-dihydroxy-9(10H)-anthracenones: Synthesis and Biological Properties

Autor: Helge Prinz, Klaus Mueller, Reinhold Altmann

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d947d9119d7cde025b9deb4266f344eb
https://doi.org/10.1002/chin.199830114

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ChemInform Abstract: 1-Arylalkyl-Substituted Anthracenones as Inhibitors of 12-Lipoxygenase Enzymes. Part 1. Structure-Activity Relationships of the Terminal Aryl Ring

Autor: Reinhold Altmann, Klaus Mueller, Helge Prinz

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5d3019fb32c02eb3078caed00a0cd2
https://doi.org/10.1002/chin.200201254

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ChemInform Abstract: 2-Arylalkyl-Substituted Anthracenones as Inhibitors of 12-Lipoxygenase Enzymes. Part 2. Structure-Activity Relationships of the Linker Chain

Autor: Helge Prinz, Reinhold Altmann, Klaus Mueller

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6a7b237aaa574cf595a956a5822d479
https://doi.org/10.1002/chin.200225092

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13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells

Autor: K. Menzel, Martin Hausmann, Daniela Vogl, Hans H Herfarth, Gerhard Rogler, Werner Falk, Arthur W. Bull, Michael Gruber, T. Spöttl, Jürgen Schölmerich, Reinhold Altmann

Publikováno v: Biochemical pharmacology. 74(4)

Background The ligand activated nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARγ) induces transcriptional repression of pro-inflammatory factors. Activation of PPARγ is followed by amelioration of colitis in animal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01137ea10a32c7c59fa224fe6244243f
https://pubmed.ncbi.nlm.nih.gov/17604003

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The interleukin 1 (IL-1) receptor accessory protein Toll/IL-1 receptor domain: analysis of putative interaction sites in vitro mutagenesis and molecular modeling

Autor: Jurgen, Radons, Stefan, Dove, Detlef, Neumann, Reinhold, Altmann, Alexander, Botzki, Michael U, Martin, Werner, Falk

Publikováno v: The Journal of biological chemistry. 278(49)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f223ae8859b14999a5e54628640d907
https://pubmed.ncbi.nlm.nih.gov/13679373

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2-Arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 2. Structure-activity relationships of the linker chain

Autor: Helge Prinz, Klaus Müller, Reinhold Altmann

Publikováno v: European journal of medicinal chemistry. 37(1)

A series of 2-arylalkyl-substituted anthracenones were tested as inhibitors of three types of 12-lipoxygenase isoforms in epidermal homogenate of mice, bovine platelets and porcine leukocytes. Their inhibitory activities were compared with those to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6cfb09a9122c0dff014572567c1b93
https://pubmed.ncbi.nlm.nih.gov/11841878

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