C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

Autor: Antoine Dufour, Caroline L. Bellac, Ulrich Eckhard, Nestor Solis, Theo Klein, Reinhild Kappelhoff, Nikolaus Fortelny, Parker Jobin, Jacob Rozmus, Jennifer Mark, Paul Pavlidis, Vincent Dive, Sean J. Barbour, Christopher M. Overall

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

IFN-γ is central in inflammatory pathogenesis, response to infection and autoimmune diseases. Here the authors show that MMP12 expression is reduced in patients with SLE and that MMP12 post-translationally truncates IFN-y, inhibiting its function an

Externí odkaz: https://doaj.org/article/0735812dd0a14d5b956358f44b2c4acb

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

Autor: Ulrich Eckhard, Pitter F. Huesgen, Oliver Schilling, Caroline L. Bellac, Georgina S. Butler, Jennifer H. Cox, Antoine Dufour, Verena Goebeler, Reinhild Kappelhoff, Ulrich auf dem Keller, Theo Klein, Philipp F. Lange, Giada Marino, Charlotte J. Morrison, Anna Prudova, David Rodriguez, Amanda E. Starr, Yili Wang, Christopher M. Overall

Publikováno v: Data in Brief, Vol 7, Iss , Pp 299-310 (2016)

The data described provide a comprehensive resource for the family-wide active site specificity portrayal of the human matrix metalloproteinase family. We used the high-throughput proteomic technique PICS (Proteomic Identification of protease Cleavag

Externí odkaz: https://doaj.org/article/ea1cfb7a0a4643beb4babc346c545730

Persistent Salmonella enterica Serovar Typhimurium Infection Induces Protease Expression During Intestinal Fibrosis

Autor: Florian Rieder, Erin C. Boyle, Reinhild Kappelhoff, Natalie Steck, Katrin Ehrhardt, Stephanie Stein, Guntram A. Grassl, B. Brett Finlay, Peter Braubach, Christopher M. Overall, Ilyssa O. Gordon

Publikováno v: Inflammatory Bowel Diseases

Background Intestinal fibrosis is a common and serious complication of Crohn’s disease characterized by the accumulation of fibroblasts, deposition of extracellular matrix, and formation of scar tissue. Although many factors including cytokines and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8ef9d6384ea452c78c72e381df4405
https://doi.org/10.1093/ibd/izz070

Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries.

Autor: Olivier Barré, Antoine Dufour, Ulrich Eckhard, Reinhild Kappelhoff, François Béliveau, Richard Leduc, Christopher M Overall

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e105984 (2014)

BACKGROUND:Type II transmembrane serine proteases (TTSPs) are a family of cell membrane tethered serine proteases with unclear roles as their cleavage site specificities and substrate degradomes have not been fully elucidated. Indeed just 52 cleavage

Externí odkaz: https://doaj.org/article/039f968a79014705949af7d6b2a3c28e

C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

Autor: Jacob Rozmus, Antoine Dufour, Nestor Solis, Theo Klein, Vincent Dive, Nikolaus Fortelny, Caroline L. Bellac, Paul Pavlidis, Christopher M. Overall, Sean J. Barbour, Jennifer Mark, Ulrich Eckhard, Reinhild Kappelhoff, Parker G. Jobin

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9, pp.2416. ⟨10.1038/s41467-018-04717-4⟩
Nature Communications, 2018, 9, pp.2416. ⟨10.1038/s41467-018-04717-4⟩

Controlled macrophage differentiation and activation in the initiation and resolution of inflammation is crucial for averting progression to chronic inflammatory and autoimmune diseases. Here we show a negative feedback mechanism for proinflammatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6d3b9826bde5c9347f77b186fd60e1
http://link.springer.com/article/10.1038/s41467-018-04717-4