Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Reinhart Kluge"'
Autor:
Heike Vogel, Dirk Montag, Timo Kanzleiter, Wenke Jonas, Daniela Matzke, Stephan Scherneck, Alexandra Chadt, Jonas Töle, Reinhart Kluge, Hans-Georg Joost, Annette Schürmann
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53025 (2013)
A region on mouse distal chromosome 1 (Chr. 1) that is highly enriched in quantitative trait loci (QTLs) controlling neural and behavioral phenotypes overlaps with the peak region of a major obesity QTL (Nob3.38), which we identified in an intercross
Externí odkaz:
https://doaj.org/article/31061d27c7fe400aaea0c2d8aba75d5d
Autor:
Matthias Becker, Wolf-Eberhard Siems, Reinhart Kluge, Florian Gembardt, Heinz-Peter Schultheiss, Michael Schirner, Thomas Walther
Publikováno v:
PLoS ONE, Vol 5, Iss 9, Pp R1423-39 (2010)
BACKGROUND: According to the World Health Organization (WHO) there is a pandemic of obesity with approximately 300 million people being obese. Typically, human obesity has a polygenetic causation. Neutral endopeptidase (NEP), also known as neprilysin
Externí odkaz:
https://doaj.org/article/5e6b7cf86ae1448b90eda69e46d7d629
Autor:
Stephan Scherneck, Matthias Nestler, Heike Vogel, Matthias Blüher, Marcel-Dominique Block, Mauricio Berriel Diaz, Stephan Herzig, Nadja Schulz, Marko Teichert, Sina Tischer, Hadi Al-Hasani, Reinhart Kluge, Annette Schürmann, Hans-Georg Joost
Publikováno v:
PLoS Genetics, Vol 5, Iss 7, p e1000541 (2009)
Polygenic type 2 diabetes in mouse models is associated with obesity and results from a combination of adipogenic and diabetogenic alleles. Here we report the identification of a candidate gene for the diabetogenic effect of a QTL (Nidd/SJL, Nidd1) c
Externí odkaz:
https://doaj.org/article/4bf80190d4df4e4ca65151081886d787
Autor:
Stephanie Krämer, Monika Reißmann, Boris Jerchow, Astrid Puppe, Kristina Ullmann, Thomas Rülicke, Elena Noe, Claudia Gosele, Anne Zintzsch, Hannah T. Nickles, Reinhart Kluge
Publikováno v:
Laboratory Animals. 51:573-582
Genetic alterations can unpredictably compromise the wellbeing of animals. Thus, more or less harmful phenotypes might appear in the animals used in research projects even when they are not subjected to experimental treatments. The severity classific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df505b73770bc6e3fd10b8e54a26553a
https://doi.org/10.1177/0023677217718863
https://doi.org/10.1177/0023677217718863
Autor:
H. P. Alizai, Rüdiger von Eisenhart-Rothe, Amro Amr, Andrea Wenger, Eiichi Tanaka, Johannes Schauwecker, Anna Henger, Chlodwig Kirchhoff, Tom Florian Ulmer, Hideyuki Wada, Hajime Narasaki, Florian Pohlig, Jens Rothenberger, Athanassious Fragoulis, Rene Tolba, Satz Mengensatzproduktion, Mark Coburn, Kerstin Pawlowsky, Andreas Kroh, Christian Stoppe, Babette Kögel, Druckerei Stückle, Takahiro Tsuchikawa, J. Tübel, H. Mühlhofer, Keisuke Okamura, Mark Bock, Hans-Eberhard Schaller, Takehiro Noji, Toshiaki Shichinohe, Henriette Dohmeier, Anne Andert, Satoshi Hirano, Julia Steitz, Reinhart Kluge, Christian D. Klink, Ulf P. Neumann, Lisa Ernst, Yuma Ebihara, Thaddäus Stopinski
Publikováno v:
European Surgical Research. 58:275-328
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9350139424b94e96c4329638846f7aaa
https://doi.org/10.1159/000479562
https://doi.org/10.1159/000479562
Autor:
Babette Kögel, Anna Henger, Lisa Ernst, Rene Tolba, Thaddäus Stopinski, Reinhart Kluge, Julia Steitz, K. Pawlowsky
Publikováno v:
European Surgical Research. 58:193-203
Background: The pig is one of the most frequently used large animal models for biomedical research, especially in the field of translational research and surgical models. While standard livestock breeds are used in short-term and acute studies, minip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36467b99adb0204f32ab4c24fd72c79c
https://doi.org/10.1159/000471483
https://doi.org/10.1159/000471483
Autor:
Regina Brigelius-Flohé, Hermann Koepsell, Alexander Jaschke, Markus Moser, Deike Hesse, Reinhart Kluge, Hans-Georg Joost, Annette Schürmann, Joerg Heeren, Dmytro Puchkov, Claudia Zahn, Bomee Chung, Klaus-Jürgen Petzke
Publikováno v:
Human Molecular Genetics
The uptake and processing of dietary lipids by the small intestine is a multistep process that involves several steps including vesicular and protein transport. The GTPase ADP-ribosylation factor-related protein 1 (ARFRP1) controls the ARF-like 1 (AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0f993d5553492c784abba5f0c9a351
https://doi.org/10.1093/hmg/dds140
https://doi.org/10.1093/hmg/dds140
Autor:
Stephan Scherneck, Susanne Neschen, Reinhart Kluge, D Kaiser, HG Joost, O Kluth, Annette Schürmann, F. Mirhashemi
Publikováno v:
Diabetologia
Aims/hypothesis Carbohydrate-free diet prevents hyperglycaemia and beta cell destruction in the New Zealand Obese (NZO) mouse model. Here we have used a sequential dietary regimen to dissociate the effects of obesity and hyperglycaemia on beta cell f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ece9b51d86b423218f9243208bfda02
https://doi.org/10.1007/s00125-010-1973-8
https://doi.org/10.1007/s00125-010-1973-8
Autor:
O Kluth, Annette Schürmann, Heike Vogel, Reinhart Kluge, HG Joost, Stephan Scherneck, Susanne Neschen, D Kaiser, F. Mirhashemi
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 119:167-171
Background: Obesity and diabetes in mice can be modified by dietary variables. Here we systematically analysed the effect of the sucrose and fat content and of the fat quality in New Zealand Obese mice, a mouse model of the metabolic syndrome. Result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4cdf092fa5595ad39c9cf8162d8d6b
https://doi.org/10.1055/s-0030-1263127
https://doi.org/10.1055/s-0030-1263127
Autor:
Hadi Al-Hasani, Alexander Jaschke, Deike Hesse, Ulrike Bernhardt, Petra Wittschen, A. Hommel, Reinhart Kluge, Hans-Georg Joost, Markus Moser, Claudia Zahn, Annette Schürmann, Achim D. Gruber
Publikováno v:
Biochemical and Biophysical Research Communications. 394:896-903
The GTPase ADP-ribosylation factor related protein 1 (ARFRP1) controls the recruitment of proteins such as golgin-245 to the trans -Golgi. ARFRP1 is highly expressed in adipose tissues in which the insulin-sensitive glucose transporter GLUT4 is proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eae5e59f79d75512d644191059d52ca
https://doi.org/10.1016/j.bbrc.2010.03.059
https://doi.org/10.1016/j.bbrc.2010.03.059