Synthetische Letalität als Therapiekonzept für die Behandlung maligner Neoplasien

Autor: Reinhardt Hc, G. S. Herter-Sprie, Shuhua Chen, Katja Höpker

Publikováno v: TumorDiagnostik & Therapie. 33:284-289

Following DNA damage, cells activate a complex DNA-damage-response (DDR) signaling network to arrest the cell cycle, repair DNA and, if the extend of damage is beyond repair capacity, induce apoptosis. DDR genes are among the most commonly mutated ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb85165e0049c8d23da105f02848a26
https://doi.org/10.1055/s-0032-1313078

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A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade.

Autor: Ibruli O; Department of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Rose F; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Beleggia F; Department of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Mildred Scheel School of Oncology Aachen Bonn Cologne Düsseldorf (MSSO ABCD), Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Schmitt A; Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Virology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Cartolano M; Department of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Fernandez LT; Department of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Saggau J; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Biochemistry I, Center for Biochemistry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Bonasera D; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Biochemistry I, Center for Biochemistry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Kiljan M; Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Gozum G; Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Lichius L; Department II of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Cai J; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Radiation Oncology and Cyberknife Center, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany., Niu LN; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Radiation Oncology and Cyberknife Center, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany., Caiaffa MI; Department of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Mildred Scheel School of Oncology Aachen Bonn Cologne Düsseldorf (MSSO ABCD), Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Herter JM; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Radiation Oncology and Cyberknife Center, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.; Department of Radiation Oncology, MVZ Prof. Dr. Uhlenbrock und Partner, Gesundheitscampus Josephs-Hospital, Warendorf, Germany., Walczak H; Institute of Biochemistry I, Center for Biochemistry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, London, UK., Liccardi G; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Biochemistry I, Center for Biochemistry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Grüll H; Institute for Diagnostic and Interventional Radiology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Büttner R; Institute of Pathology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Bosco G; Department of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., George J; Department of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Department of Otorhinolaryngology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany., Thomas RK; Department of Translational Genomics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Pathology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Bozek K; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute for Biomedical Informatics, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany.; West German Cancer Center, University Hospital Essen, Essen, Germany.; DKTK Partner Site Essen/Düsseldorf, University Hospital Essen, Essen, Germany.; Center for Molecular Biotechnology, University Hospital Essen, Essen, Germany., Herter-Sprie GS; Department I of Internal Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany. grit.herter-sprie@fachklinik-hornheide.de.; Center for Molecular Medicine Cologne, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany. grit.herter-sprie@fachklinik-hornheide.de.; Department of Medical Oncology, Fachklinik Hornheide, Münster, Germany. grit.herter-sprie@fachklinik-hornheide.de.

Publikováno v: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2024 Nov 14; Vol. 150 (11), pp. 496. Date of Electronic Publication: 2024 Nov 14.

Correction: ECP versus ruxolitinib in steroid-refractory chronic GVHD - a retrospective study by the EBMT transplant complications working party.

Autor: Penack O; Medical Clinic, Department for Haematology, Oncology and Tumorimmunology, Charité Universitätsmedizin Berlin, Berlin, Germany. olaf.penack@charite.de.; EBMT Transplant Complications Working Party, Paris, France. olaf.penack@charite.de., Peczynski C; EBMT Transplant Complications Working Party, Paris, France.; CHU de Saint-Etienne, Hematology, Saint-Etienne, France., Boreland W; EBMT Transplant Complications Working Party, Paris, France.; CHU de Saint-Etienne, Hematology, Saint-Etienne, France., Lemaitre J; EBMT Transplant Complications Working Party, Paris, France.; CHU de Saint-Etienne, Hematology, Saint-Etienne, France., Reinhardt HC; University Hospital, Essen, Germany., Afanasyeva K; RM Gorbacheva Research Institute, Pavlov University, St Petersburg, Russia., Avenoso D; Kings' College Hospital, London, UK., Holderried TAW; Department of Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, Bonn, Germany., Kornblit BT; Rigshospitalet, Copenhagen, Denmark., Gavriilaki E; Papanicolaou G. Hospital, Thessaloniki, Greece., Martinez C; Hematopoietic Stem Cell Unit, Hematology Department, ICMHO, Hospital Clínic of Barcelona, University of Barcelona, Barcelona, Spain., Chiusolo P; Fondazione Policlinico Universitario A. Gemelli IRCCS-Università Cattolica del Sacro Cuore-Roma, Roma, Italy., Mico MC; ASST Papa Giovanni XXIII, Bergamo, Italy., Daguenet E; Institut de Cancerologie Lucien Neuwirth, Saint-Étienne, France., Wichert S; Skåne University Hospital in Lund, Lund, Sweden., Ozdogu H; Department of Hematology, Baskent University Hospital, Adana, Türkiye., Piekarska A; Department of Hematology and Transplantology, University Clinical Center and Medical University of Gdansk, Gdańsk, Poland., Kinsella F; University Hospital Birmingham NHS Trust, Birmingham, UK., Basak GW; EBMT Transplant Complications Working Party, Paris, France.; Department of Hematology, Oncology and Internal Medicine, the Medical University of Warsaw, Warsaw, Poland., Schoemans H; EBMT Transplant Complications Working Party, Paris, France.; Department of Hematology, University Hospitals Leuven, Leuven, Belgium.; Department of Public Health and Primary Care, ACCENT VV, KU Leuven - University of Leuven, Leuven, Belgium., Koenecke C; EBMT Transplant Complications Working Party, Paris, France.; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Moiseev I; RM Gorbacheva Research Institute, Pavlov University, St Petersburg, Russia., Peric Z; EBMT Transplant Complications Working Party, Paris, France.; Department of Haematology, University Hospital Centre Rijeka, Rijeka, Croatia.

Publikováno v: Bone marrow transplantation [Bone Marrow Transplant] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.