Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Reinhard Zeisig"'
Publikováno v:
Breast Cancer Research and Treatment. 87:245-254
The study was performed to investigate the potency of liposomal formulations to reduce or to overcome tamoxifen resistance. Therefore, estrogen receptor (ER) positive MCF-7 and ER deficient NCI/ADR cells with different sensitivity to tamoxifen were u
Publikováno v:
European Journal of Cancer. 40:845-851
Tumours in hormone-regulated organs such as the breast, prostate or ovaries are among the most frequent malignancies. Because of their endocrine-dependent development and growth, they offer a unique opportunity for antihormonal treatment either singl
Publikováno v:
Cancer Gene Therapy. 10:302-311
To improve liposomal gene transfer we investigated the influence of membrane-interacting alkylphospholipids (APLs) on gene transfer efficiency in vitro and in vivo using the LacZ reporter gene and the cytosine deaminase (CD) suicide gene. Liposomes w
Publikováno v:
Breast Cancer Research and Treatment. 58:71-80
The pharmacokinetics of free and different liposomal formulations of hexadecylphosphocholine (HPC) was investigated in tumor-bearing (human mammary tumor MaTu) and tumor-free mice after intravenous and intraperitoneal administration. The levels of HP
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1414(1-2):238-248
Liposomes from octadecyl-(1,1-dimethyl-4-piperidino-4-yl)-phosphate (OPP), a new alkylphospholipid derivative with an improved cancerostatic activity, were prepared for the first time and the activity in vitro and in vivo was characterised. The forma
Autor:
A. Wulf-Goldenberg, Martin Schostak, Joerg Hennenlotter, A. Jandrig, S. Flechsig, Iduna Fichtner, Reinhard Zeisig, C. Schmees, Jens Hoffmann, Jens Bedke, M. Becker, A. Stenzl
Publikováno v:
European Journal of Cancer. 69:S73
Autor:
D. Arndt, Mike C. Bibby, Reinhard Zeisig, S. Jungmann, G. Asongwe, Helga Naundorf, John A. Double, Iduna Fichtner
Publikováno v:
Breast Cancer Research and Treatment. 32:269-279
This study examines the in vitro and in vivo activity of alkylphosphocholines (APC) in experimental human breast carcinomas. Three analogs, hexadecylphosphocholine (HPC), octadecylphosphocholine (OPC) and eicosanylphosphocholine (EPC) were investigat
Publikováno v:
Anti-Cancer Drugs. 4:57-64
We investigated the liposome forming properties of three homologues of alkylphosphocholines: hexadecylphosphocholine (HPC), octadecylphosphocholine (OPC) and eicosanylphosphocholine (EPC). In the presence of cholesterol and dicetylphosphate, alkylpho
Publikováno v:
Anti-Cancer Drugs. 2:411-418
Hexadecylphosphocholine (HPC) and its analogs with a longer alkyl chain (C18 and C20) were examined for antineoplastic activity in the murine tumor models P388 leukemia, B 16 melanoma, the mammary carcinoma C3H and Ca 755, and the human MT-1 mammary
Publikováno v:
Cellular and molecular life sciences : CMLS. 58(1)
E-selectin, exclusively expressed on activated endothelial cells, is a potential target for site-directed delivery of agents. We and others have shown that sialyl LewisX-liposomes (sLe(x)-liposomes) are recognized by E-selectin. We now report an appr