Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Reinhard Lorenz"'
Autor:
Elena L. Kopp, Daniel N. Deussen, Raphael Cuomo, Reinhard Lorenz, David M. Roth, Sushil K. Mahata, Hemal H. Patel
Publikováno v:
Cells, Vol 12, Iss 24, p 2786 (2023)
Type 2 diabetes (T2D) has a complex pathophysiology which makes modeling the disease difficult. We aimed to develop a novel model for simulating T2D in vitro, including hyperglycemia, hyperlipidemia, and variably elevated insulin levels targeting mus
Externí odkaz:
https://doaj.org/article/e19c7bd6e49641b7a54de4fd681033b0
Publikováno v:
Platelets, Vol 31, Iss 8, Pp 989-992 (2020)
Externí odkaz:
https://doaj.org/article/d273fc43a5224e1daf74524af4f523e4
Autor:
Hans-Christoph Aster, Marcel Romanos, Susanne Walitza, Manfred Gerlach, Andreas Mühlberger, Albert Rizzo, Marta Andreatta, Natalie Hasenauer, Philipp E. Hartrampf, Kai Nerlich, Christoph Reiners, Reinhard Lorenz, Andreas K. Buck, Lorenz Deserno
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Background:Methylphenidate (MPH) is the first-line pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD). MPH binds to the dopamine (DA) transporter (DAT), which has high density in the striatum. Assessments of the striatal dop
Externí odkaz:
https://doaj.org/article/bc0aa0c0aeb944de92d9571e40a108a6
Autor:
Luise Goldmann, Rundan Duan, Thorsten Kragh, Georg Wittmann, Christian Weber, Reinhard Lorenz, Philipp von Hundelshausen, Michael Spannagl, Wolfgang Siess
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 4021-4033 (2019)
Abstract: Activation of the platelet Fc-receptor CD32a (FcγRIIA) is an early and crucial step in the pathogenesis of heparin-induced thrombocytopenia type II (HIT) that has not been therapeutically targeted. Downstream FcγRIIA Bruton tyrosine kinas
Externí odkaz:
https://doaj.org/article/2d9e7772bfc94b21ac3710a27736c30e
Autor:
Janina Jamasbi, RPh, Remco T.A. Megens, PhD, Mariaelvy Bianchini, MSc, Kerstin Uhland, PhD, Götz Münch, MD, Martin Ungerer, MD, Shachar Sherman, BSc, Alexander Faussner, PhD, Richard Brandl, MD, Christine John, MSc, Johannes Buchner, PhD, Christian Weber, MD, Reinhard Lorenz, MD, Natalie Elia, PhD, Wolfgang Siess, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 3, Pp 131-142 (2016)
To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc. Cross-linking potentiated the inhibition of
Externí odkaz:
https://doaj.org/article/61bf0fc198ea4ad180b532af81574356
Autor:
Florian Brodkorb, Björn Fischer, Katrin Kalbfleisch, Oliver Robers, Carina Braun, Sophia Dohlen, Judith Kreyenschmidt, Reinhard Lorenz, Martin Kreyenschmidt
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 20050-20066 (2015)
The use of biocidal compounds in polymers is steadily increasing because it is one solution to the need for safety and hygiene. It is possible to incorporate an antimicrobial moiety to a polymer. These polymers are referred to as intrinsic antimicrob
Externí odkaz:
https://doaj.org/article/cecd22a70215498bab263ccdcf27b73f
Autor:
Heidrun Degen, Oliver Borst, Melanie Ziegler, Ann‐Katrin Mojica Munoz, Janina Jamasbi, Britta Walker, Silvia Göbel, Julia Fassbender, Kristin Adler, Richard Brandl, Götz Münch, Reinhard Lorenz, Wolfgang Siess, Meinrad Gawaz, Martin Ungerer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 8 (2017)
BackgroundGPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI‐Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding in clinical studies. GPVI‐Fc is
Externí odkaz:
https://doaj.org/article/8c41f738c98d45e59044b26e25dfec32
Publikováno v:
Thrombosis and Haemostasis. 121(11):1395-1399
A series of cases with rare thromboembolic incidents including cerebral sinus vein thrombosis (some of them fatal) and concomitant thrombocytopenia occurring shortly after vaccination with the coronavirus disease 2019 (COVID-19) vaccine AZD1222 (Vaxz
Autor:
Xavier Blanchet, Wolfgang Siess, Danmei Zhang, Mariam Ebrahim, Kerstin Uhland, Götz Münch, Reinhard Lorenz, Remco T. A. Megens, Christian Weber, Kristin Adler, Hans Deckmyn, Martin Ungerer, Natalie Elia, Janina Jamasbi
Publikováno v:
Thrombosis and Haemostasis, 120(6), 977-993. Georg Thieme Verlag
Glycoprotein VI (GPVI), a platelet collagen receptor, is crucial in mediating atherothrombosis. Besides collagen, injured plaques expose tissue factor (TF) that triggers fibrin formation. Previous studies reported that GPVI also is a platelet recepto
Autor:
Isabell Bernlochner, Christian Weber, Wolfgang Siess, Reinhard Lorenz, Kristina Busygina, Viola Denzinger
Publikováno v:
Thrombosis and Haemostasis, 119(8), 1212-1221. Georg Thieme Verlag
Bruton's tyrosine kinase (Btk) is essential for B cell differentiation and proliferation, but also platelets express Btk. Patients with X-linked agammaglobulinemia due to hereditary Btk deficiency do not show bleeding, but a mild bleeding tendency is