Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Reinhard Kreiling"'
Publikováno v:
Archives of Toxicology
This article presents the outcomes of higher-tier repeated-dose toxicity studies and developmental and reproductive toxicity (DART) studies using Wistar rats requested for methyl paraben and propyl paraben under the European Union chemicals legislati
Publikováno v:
ALTEX. 38(4)
EU cosmetic ingredients are governed by two regulations that conflict. Regulation EC 1223/2009, the Cosmetic Regulation, bans in vivo (animal) testing for cosmetic product safety assessments, including both final products and ingredients. At the same
Autor:
Alejandro Aguayo-Orozco, Wolfgang Moritz, Wiebke Albrecht, Christoph van Thriel, Heidrun Ellinger-Ziegelbauer, Susann Fayyaz, Tobias S. Schiergens, Anne Cathrin Behr, Anett Ullrich, José V. Castell, Karolina Edlund, Franziska Kappenberg, Georg Damm, Leon van Aerts, Nachiket Vartak, Dieter Runge, Iain Gardner, Jörg Reinders, Ahmed Ghallab, Marcel Leist, Reinhard Kreiling, Agapios Sachinidis, Bård Smedsrød, Tim Brecklinghaus, Thomas Steger-Hartmann, Albert Braeuning, Anja Zeigerer, Daniel Seehofer, Thorsten Buhrke, Marianna Grinberg, Rosemarie Marchan, Laia Tolosa, Cristina Cadenas, Lars Kuepfer, Jörg Rahnenführer, Bob van de Water, Mian Zhang, Alfonso Lampen, Hendrik Kirschner, Regina Stoeber, Axel Oberemm, Kristina E Ebbert, Naim Kittana, Xiaolong Gu, Jan G. Hengstler, Klaus Golka, Ursula Gundert-Remy, Serene M. L. Lee
Publikováno v:
Archives of Toxicology
ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Archives of toxicology, 93:1609-1637
Albrecht, W, Kappenberg, F, Brecklinghaus, T, Stoeber, R, Marchan, R, Zhang, M, Ebbert, K, Kirschner, H, Grinberg, M, Leist, M, Moritz, W, Cadenas, C, Ghallab, A, Reinders, J, Vartak, N, van Thriel, C, Golka, K, Tolosa, L, Castell, J V, Damm, G, Seehofer, D, Lampen, A, Braeuning, A, Buhrke, T, Behr, A-C, Oberemm, A, Gu, X, Kittana, N, van de Water, B, Kreiling, R, Fayyaz, S, van Aerts, L, Smedsrød, B, Ellinger-Ziegelbauer, H, Steger-Hartmann, T, Gundert-Remy, U, Zeigerer, A, Ullrich, A, Runge, D, Lee, S M L, Schiergens, T S, Kuepfer, L, Aguayo-Orozco, A, Sachinidis, A, Edlund, K, Gardner, I, Rahnenführer, J & Hengstler, J G 2019, ' Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations ', Archives of Toxicology, vol. 93, no. 6, pp. 1609-1637 . https://doi.org/10.1007/s00204-019-02492-9
Archives of Toxicology, 93(6), 1609-1637
Arch. Toxicol. 93, 1609-1637 (2019)
ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Archives of toxicology, 93:1609-1637
Albrecht, W, Kappenberg, F, Brecklinghaus, T, Stoeber, R, Marchan, R, Zhang, M, Ebbert, K, Kirschner, H, Grinberg, M, Leist, M, Moritz, W, Cadenas, C, Ghallab, A, Reinders, J, Vartak, N, van Thriel, C, Golka, K, Tolosa, L, Castell, J V, Damm, G, Seehofer, D, Lampen, A, Braeuning, A, Buhrke, T, Behr, A-C, Oberemm, A, Gu, X, Kittana, N, van de Water, B, Kreiling, R, Fayyaz, S, van Aerts, L, Smedsrød, B, Ellinger-Ziegelbauer, H, Steger-Hartmann, T, Gundert-Remy, U, Zeigerer, A, Ullrich, A, Runge, D, Lee, S M L, Schiergens, T S, Kuepfer, L, Aguayo-Orozco, A, Sachinidis, A, Edlund, K, Gardner, I, Rahnenführer, J & Hengstler, J G 2019, ' Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations ', Archives of Toxicology, vol. 93, no. 6, pp. 1609-1637 . https://doi.org/10.1007/s00204-019-02492-9
Archives of Toxicology, 93(6), 1609-1637
Arch. Toxicol. 93, 1609-1637 (2019)
Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or the determination of an acceptable daily intake (ADI). To over
Autor:
B. Montemayor, R. Taalman, Rajeshwar P. Verma, Hajime Kojima, J. Field, Matt Dent, Vera Rogiers, C. Willett, Janine Ezendam, João Barroso, Gladys Ouedraogo, M. Lorencini, Chihae Yang, Tara S. Barton-Maclaren, Susanne Hougaard Bennekou, Paul L. Carmichael, E. Vaillancourt, Suzanne Fitzpatrick, Reinhard Kreiling, J. Ansell, R. Mazaro-Costa, J. Oliveira, Russell S. Thomas, Kim Boekelheide, D. Smegal, Catherine Mahony, Y. Tokura, M. Hatao
Publikováno v:
Dent, M P, Vaillancourt, E, Thomas, R S, Carmichael, P L, Ouedraogo, G, Kojima, H, Barroso, J, Ansell, J, Barton-Maclaren, T S, Bennekou, S H, Boekelheide, K, Ezendam, J, Field, J, Fitzpatrick, S, Hatao, M, Kreiling, R, Lorencini, M, Mahony, C, Montemayor, B, Mazaro-Costa, R, Oliveira, J, Rogiers, V, Smegal, D, Taalman, R, Tokura, Y, Verma, R, Willett, C & Yang, C 2021, ' Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients ', Regulatory Toxicology and Pharmacology, vol. 125, 105026 . https://doi.org/10.1016/j.yrtph.2021.105026
Next generation risk assessment (NGRA) is an exposure-led, hypothesis-driven approach that has the potential to support animal-free safety decision-making. However, significant effort is needed to develop and test the in vitro and in silico (computat
Autor:
Gladys Ouedraogo, Camilla Alexander-White, Dagmar Bury, Harvey J. Clewell, Mark Cronin, Tom Cull, Matthew Dent, Bertrand Desprez, Ann Detroyer, Corie Ellison, Stefania Giammanco, Eric Hack, Nicola J. Hewitt, Gerry Kenna, Martina Klaric, Reinhard Kreiling, Cathy Lester, Catherine Mahony, Enrico Mombelli, Jorge Naciff, John O'Brien, Andreas Schepky, Sarah Tozer, Bart van der Burg, Barbara van Vugt-Lussenburg, Sharon Stuard, null Cosmetics Europe
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 132
Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals, pharmaceuticals, food and cosmetics. This illustrative case study with propylparaben (PP) demonstrates
Autor:
Pedro Amores Da Silva, Hajime Kojima, Rajeshwar P. Verma, Petra S. Kern, Stanley Milstein, Beta Montemayor, Yutaka Kasai, Fanny Boisleve, Jay Ansell, Akihiko Hirose, Masato Hatao, Renata Teixeira Amaral, Julcemara Oliveira, Eric Vaillancourt, Craig Weiss, Andrea Richarz, Rob Taalman, Nashira Vieira O.Reilly Cabral Posada, Matthew P. Dent, Reinhard Kreiling
Publikováno v:
Computational Toxicology. 7:20-26
Consumer safety is a prerequisite for any cosmetic product. Worldwide, there is an ever-increasing desire to bring safe products to market without animal testing, which requires a new approach to consumer safety. ‘Next Generation Risk Assessment’
Autor:
Karin Michel, Wendel Wohlleben, Nicole Neubauer, Robert Landsiedel, Karin Wiench, Athena M. Keene, Muhammad-Adeel Irfan, Monika Maier, Josje H.E. Arts, Thomas Petry, David B. Warheit, Ursula G. Sauer, Reinhard Kreiling, Delina Lyon
Publikováno v:
Regulatory Toxicology and Pharmacology. 76:234-261
Case studies covering carbonaceous nanomaterials, metal oxide and metal sulphate nanomaterials, amorphous silica and organic pigments were performed to assess the Decision-making framework for the grouping and testing of nanomaterials (DF4nanoGroupin
Autor:
Ursula G. Sauer, Reinhard Kreiling
Publikováno v:
Regulatory Toxicology and Pharmacology. 109:104501
This article presents the Grouping and Assessment Strategy for Organic P igm e nts (GRAPE). GRAPE is driven by the hypotheses that low (bio)dissolution and low permeability indicate absence of systemic bioavailability and hence no systemic toxicity p
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 100
In 2013, an ECETOC Task Force evaluated scientific understanding of the 'lung overload' hypothesis. As there is no evidence that humans develop lung tumours following exposure to poorly soluble particles (PSPs), emphasis was given to the observed hig
Autor:
David Hart, Ursula G. Sauer, Reinhard Kreiling, Dorothea Eigler, Peter Ungeheuer, Thomas H. Broschard, Joanna Kupny, Qiang Li, Marcus Kleber, Birte Dreeßen, Veronika Höpflinger, Helge Gehrke
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 90
The applicability of the Direct Peptide Reactivity Assay (DPRA), the KeratinoSens™ assay and the human cell line activation test (OECD Test Guidelines 442C, 442D, 442E) in predicting the skin sensitising potential of nine lipid (bio)chemicals was i