Výsledky vyhledávání - "Reinhard, Rosinke"

Targeting c-kit receptor in neuroblastomas and colorectal cancers using stem cell factor (SCF)-based recombinant bacterial toxins

Autor: Rama Shanker Verma, Janendra K. Batra, Stefan Barth, Reinhard Rosinke, Alessa Pardo, Swati Choudhary

Publikováno v: Applied Microbiology and Biotechnology. 100:263-277

Autocrine activation of c-kit (KIT receptor tyrosine kinase) has been postulated to be a potent oncogenic driver in small cell lung cancer, neuroblastoma (NB), and poorly differentiated colorectal carcinoma (CRC). Although targeted therapy involving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7162f7b5ffdbb5ea866f44f0aebf09a7
https://doi.org/10.1007/s00253-015-6978-2

Zobrazit plný text záznamu

Targetedex vivoreduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins

Autor: Stefan Barth, Edgar Jost, Theo Thepen, Grit Hehmann-Titt, Sonja Schiffer, Georg Melmer, Michael Huhn, Reinhard Rosinke

Publikováno v: International Journal of Cancer. 135:1497-1508

CMML (chronic myelomonocytic leukemia) belongs to the group of myeloid neoplasms known as myelodysplastic and myeloproliferative diseases. In some patients with a history of CMML, the disease transforms to acute myelomonocytic leukemia (AMML). There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f1d4ae54898d6f809af10e24dd8d4fd
https://doi.org/10.1002/ijc.28786

Zobrazit plný text záznamu

Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins

Autor: Sonja, Schiffer, Reinhard, Rosinke, Edgar, Jost, Grit, Hehmann-Titt, Michael, Huhn, Georg, Melmer, Stefan, Barth, Theo, Thepen

Publikováno v: International journal of cancer. 135(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2214f43254ab68e9e4e3c14462c57c69
https://pubmed.ncbi.nlm.nih.gov/24523193

Zobrazit plný text záznamu

Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes

Autor: Stefan Barth, T. Thepen, Edgar Jost, Michael Stöcker, Reinhard Rosinke, Rainer Fischer, Bettina Stahnke, Mehmet Kemal Tur

Publikováno v: Molecular cancer therapeutics. 7(9)

Acute myeloid leukemia (AML) cells of subtypes M4 and M5 show enhanced expression of CD64 (FcγRI), the high-affinity receptor for IgG, which is normally expressed at high levels only on activated cells of the myeloid lineage. CD64 is therefore a pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f633f7b5070a0f62f7de8a8cf6392c4f
https://pubmed.ncbi.nlm.nih.gov/18790773

Zobrazit plný text záznamu

Abstract B240: Novel protein fusion toxins targeting c-kit positive neuroendocrine tumors

Autor: Alessa Pardo, Janendra K. Batra, Swati Choudhary, Stefan Barth, Reinhard Rosinke, Rama Shanker Verma

Publikováno v: Molecular Cancer Therapeutics. 12:B240-B240

Currently, the treatment options for patients with neuroendocrine carcinomas (NECs) are limited. Stem cell factor is found to have a trophic role in neuroendocrine cancer cells through an autocrine growth loop, which leads to the activation of the c-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68acad7066c106a739334b0b069fd4a1
https://doi.org/10.1158/1535-7163.targ-13-b240

Zobrazit plný text záznamu