Zobrazeno 1 - 10
of 466
pro vyhledávání: '"Reinhard, Jahn"'
Autor:
Seiichi Koike, Reinhard Jahn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract In the secretory pathway the destination of trafficking vesicles is determined by specific proteins that, with the notable exception of SNAREs, are recruited from soluble pools. Previously we have shown that microinjected proteoliposomes con
Externí odkaz:
https://doaj.org/article/b270f064a85c4cb3838c702ff058a2bc
Autor:
Hsin-Fang Chang, Claudia Schirra, Momchil Ninov, Ulrike Hahn, Keerthana Ravichandran, Elmar Krause, Ute Becherer, Štefan Bálint, Maria Harkiolaki, Henning Urlaub, Salvatore Valitutti, Cosima T. Baldari, Michael L. Dustin, Reinhard Jahn, Jens Rettig
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological
Externí odkaz:
https://doaj.org/article/31a8c24e301a4df68584d46846ad161c
Autor:
Lado Otrin, Agata Witkowska, Nika Marušič, Ziliang Zhao, Rafael B. Lira, Fotis L. Kyrilis, Farzad Hamdi, Ivan Ivanov, Reinhard Lipowsky, Panagiotis L. Kastritis, Rumiana Dimova, Kai Sundmacher, Reinhard Jahn, Tanja Vidaković-Koch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
A variety of artificial cells springs from the functionalization of liposomes with proteins but these models suffer from low durability without repair and replenishment mechanisms. Here, the authors show that synthetic amphiphile membranes undergo SN
Externí odkaz:
https://doaj.org/article/87cfa0761f1749479e110459d224a55d
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Proteins need to overcome energy barriers to induce intermediate steps in membrane fusion. Using lipid vesicles in which progression to hemifusion is arrested, the authors show that the metastable intermediate is enhanced by divalent cations and is c
Externí odkaz:
https://doaj.org/article/901cfa95a349420482eaf82f901e41d0
Autor:
Changwon Kim, Min Ju Shon, Sung Hyun Kim, Gee Sung Eun, Je-Kyung Ryu, Changbong Hyeon, Reinhard Jahn, Tae-Young Yoon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Fueled by ATP hydrolysis in N-ethylmaleimide sensitive factor (NSF), the 20S complex disassembles SNARE complexes in a single unravelling step. Here authors use single-molecule methods to show cooperativity between the NSF and SNARE complex, which pr
Externí odkaz:
https://doaj.org/article/dd60350dcd5e49ba857d5c759b956209
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/21abe6fbb4934a5abe97f0de95ed42f5
Autor:
Sabine Wittig, Marcelo Ganzella, Marie Barth, Susann Kostmann, Dietmar Riedel, Ángel Pérez-Lara, Reinhard Jahn, Carla Schmidt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Synaptic vesicles store neurotransmitters and fuse with the pre-synaptic membrane when an action potential arrives at the nerve terminal. Here authors apply cross-linking mass spectrometry to study interactions of synaptic vesicle proteins and descri
Externí odkaz:
https://doaj.org/article/c3cf31e15d2448abbfa6da7820c787aa
Autor:
Alex J. B. Kreutzberger, Volker Kiessling, Christopher Stroupe, Binyong Liang, Julia Preobraschenski, Marcelo Ganzella, Mark A. B. Kreutzberger, Robert Nakamoto, Reinhard Jahn, J. David Castle, Lukas K. Tamm
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries. Here authors compare SNARE-mediated fusion of purified synaptic vesicles with insulin vesicle
Externí odkaz:
https://doaj.org/article/4a79a606ae254e35b295a19f8e1dafc2
Autor:
Seiichi Koike, Reinhard Jahn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Intracellular vesicle targeting is mediated by Rab GTPases that cooperate with phosphatidylinositides and SNARE proteins, which then facilitate membrane fusion. Here, the authors microinject artificial vesicles into HeLa cells and find that SNAREs pl
Externí odkaz:
https://doaj.org/article/6dd1376363bc458ab11ca7f21b655c37
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108623- (2021)
Summary: Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate. VGLUTs were originally identified as sodium-dependent transporters of inorganic phosphate (Pi), but the physiological relevance of this activity remains unclear
Externí odkaz:
https://doaj.org/article/be1df134e4124d34b09a998aa0210f72