Targeted delivery of CCR2 antagonist to activated pulmonary endothelium prevents metastasis

Autor: Maya Simionescu, Martin Schlesinger, Lubor Borsig, Manuela Calin, Daniela Stan, Reiner Zeisig, Marko Roblek, Gerd Bendas

Publikováno v: Journal of Controlled Release

Enhanced levels of the inflammatory chemokine CCL2 are known to correlate with increased tumorigenesis and metastases, and thereby poor prognosis for cancer patients. The CCL2-CCR2 chemokine axis was shown to facilitate the metastatic initiation thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c25985c6afbb7ea1541e1d7855c929e

Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation

Autor: Jane Wenzel, Sylvia Habedank, Wolfram Haider, Reiner Zeisig, Iduna Fichtner

Publikováno v: Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, Springer Verlag, 2009, 121 (1), pp.13-22. ⟨10.1007/s10549-009-0448-4⟩

International audience; The process of metastasis formation in cancer is not completely understood and is the main reason cancer therapies fail. Previously, we showed that dual liposomes simultaneously containing the hemostatic inhibitor, dipyridamol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c11ad8cf177f0d8abe2dcffee3a45b
https://doi.org/10.1007/s10549-009-0448-4

Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in vitro and increased lung metastasis in NOD/SCID mice

Autor: Tilen Koklic, Burkhard Wiesner, Iduna Fichtner, Marjeta Šentjurc, Reiner Zeisig

Publikováno v: Archives of Biochemistry and Biophysics. 459:98-106

To study whether membrane fluidity of tumor cells have an influence on metastasis, MT3 breast cancer cells harvested during exponential growth and under confluent conditions were compared. Electron paramagnetic resonance (EPR) data revealed that, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee050b0fcb4cdd7c450e9e088cc0197
https://doi.org/10.1016/j.abb.2006.09.030

How perifosine affects liposome-encapsulated drug delivery across a cell barrier

Autor: Reiner Zeisig, Anze Testen, Tilen Koklic, Janez Štrancar, Rok Podlipec, Andrea Orthmann, Marjeta Šentjurc, Janez Mravljak

Publikováno v: Therapeutic delivery. 6(4)

Background: The development of efficient drug delivery systems to transport therapeutics across barrier-forming cells remains a challenge. Recently it was shown that liposomes containing perifosine, a synthetic analog of lysophosphatidylcholine, effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4160000b2eec1c2a4d64f5b9a8fb0353
https://pubmed.ncbi.nlm.nih.gov/25996042

Structure–activity relationship study of dendritic polyglycerolamines for efficient siRNA transfection

Autor: Sabrina Pricl, Rainer Haag, Erik Laurini, Paola Posocco, Marcelo Calderón, Reiner Zeisig, Wolfgang Kemmner, Ole Hirsch, Fatemeh Sheikhi Mehrabadi

Structure–activity relationship studies are pivotal in the development of existing small interfering RNA (siRNA) nanocarriers and in designing new delivery systems. In this paper, we investigated the ability of four dendritic polyglycerolamines (dP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3620d61a76206150efb73c3c7aa4cb
http://hdl.handle.net/11368/2845605