Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Reiner K. Mailer"'
Autor:
Hanna Englert, Josephine Göbel, Danika Khong, Maryam Omidi, Nina Wolska, Sandra Konrath, Maike Frye, Reiner K. Mailer, Manu Beerens, Julian C. Gerwers, Roger J. S. Preston, Jacob Odeberg, Lynn M. Butler, Coen Maas, Evi X. Stavrou, Tobias A. Fuchs, Thomas Renné
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundNeutrophil Extracellular Traps (NETs) are key mediators of immunothrombotic mechanisms and defective clearance of NETs from the circulation underlies an array of thrombotic, inflammatory, infectious, and autoimmune diseases. Efficient NET d
Externí odkaz:
https://doaj.org/article/9aed362b20df48998e4383fc4e6df556
Autor:
Anita Badbaran, Reiner K. Mailer, Christine Dahlke, Jannis Woens, Anahita Fathi, Sibylle C. Mellinghoff, Thomas Renné, Marylyn M. Addo, Kristoffer Riecken, Boris Fehse
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 418-423 (2021)
Vaccination with the adenoviral-vector-based AstraZeneca ChAdOx1 nCov-19 (Vaxzevria) vaccine is efficient and safe. However, in rare cases vaccinated individuals developed life-threatening thrombotic complications, including thrombosis in cerebral si
Externí odkaz:
https://doaj.org/article/97dddc9b37914335aeef42ff2fd621b8
Autor:
Marco Heestermans, Clément Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A. Friese, Mathias Gelderblom, Albert Sickmann, Roger J. S. Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M. Butler, Ophira Salomon, Evi X. Stavrou, Thomas Renné
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the
Externí odkaz:
https://doaj.org/article/23842f92b8124cd4863e0db2254038e6
Autor:
Sandra Konrath, Reiner K. Mailer, Manu Beerens, Hanna Englert, Maike Frye, Piotr Kuta, Roger J. S. Preston, Coen Maas, Lynn M. Butler, Mark Roest, Bas de Laat, Thomas Renné
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Calibrated Automated Thrombography (CAT) is a versatile and sensitive method for analyzing coagulation reactions culminating in thrombin generation (TG). Here, we present a CAT method for analyzing TG in murine whole blood by adapting the CAT assay u
Externí odkaz:
https://doaj.org/article/ea917332e07143deb5c08fe5ee31705f
Autor:
Hanna Englert, Chandini Rangaswamy, Carsten Deppermann, Jan-Peter Sperhake, Christoph Krisp, Danny Schreier, Emma Gordon, Sandra Konrath, Munif Haddad, Giordano Pula, Reiner K. Mailer, Hartmut Schlüter, Stefan Kluge, Florian Langer, Klaus Püschel, Kosta Panousis, Evi X. Stavrou, Coen Maas, Thomas Renné, Maike Frye
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103382- (2021)
Background: Coagulopathy and inflammation are hallmarks of Coronavirus disease 2019 (COVID-19) and are associated with increased mortality. Clinical and experimental data have revealed a role for neutrophil extracellular traps (NETs) in COVID-19 dise
Externí odkaz:
https://doaj.org/article/f07dda3a7eaf4a2991a79c421ec628e9
Autor:
Reiner K. Mailer
Publikováno v:
Frontiers in Pediatrics, Vol 8 (2020)
The transcription factor FOXP3 controls the immunosuppressive program in CD4+ T cells that is crucial for systemic immune regulation. Mutations of the single X-chromosomal FOXP3 gene in male individuals cause the inherited autoimmune disease immune d
Externí odkaz:
https://doaj.org/article/99f0d9f89dd743288517d07f2fc9573e
Autor:
Aishwarya R. Vaidya, Nina Wolska, Dina Vara, Reiner K. Mailer, Katrin Schröder, Giordano Pula
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 706 (2021)
Diabetes mellitus is the fifth most common cause of death worldwide. Due to its chronic nature, diabetes is a debilitating disease for the patient and a relevant cost for the national health system. Type 2 diabetes mellitus is the most common form of
Externí odkaz:
https://doaj.org/article/828043f025d445dfab7847211f8cdd39
Autor:
Bastian F. J. Plochg, Hanna Englert, Chandini Rangaswamy, Sandra Konrath, Mandy Malle, Sibylle Lampalzer, Claudia Beisel, Salma Wollin, Maike Frye, Jens Aberle, Johannes Kluwe, Thomas Renné, Reiner K. Mailer
Publikováno v:
Journal of Internal Medicine. 291:648-664
Liver-derived apolipoprotein B-100 (ApoB100) is an autoantigen that is recognized by atherogenic CD4We identified ApoB100-specific T cells in blood from healthy controls, nonalcoholic fatty liver disease (NAFLD) patients, and CVD patients by activati
Autor:
Andreas Büttner, Michael Lalk, Raghavendra Palankar, Stefan Kochanek, Reiner K. Mailer, Evi X. Stavrou, Uwe Völker, Karen Methling, Thomas Renné, Konstanze Aurich, Leif Steil, Thomas Thiele, Lea Krutzke, Martin Beer, Maike Frye, Kathleen Selleng, Theodore E. Warkentin, Chandini Rangaswamy, Hanna Englert, Martina Wolff, Stephan Michalik, Linda Schönborn, Nicole Endlich, Florian Siegerist, Alexander Reder, Boris Fehse, Christian Hentschker, Jan Wesche, Stefan Handtke, Andreas Greinacher, Kati Franzke
Publikováno v:
Blood
SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models, and analysis of VITT patient samples, we identified de
Publikováno v:
Hämostaseologie. 41:489-501
Factor XII (FXII) is a serine protease zymogen produced by hepatocytes and secreted into plasma. The highly glycosylated coagulation protein consists of six domains and a proline-rich region that regulate activation and function. Activation of FXII r