A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells.

Autor: Soledad Galli, Olaf Jahn, Reiner Hitt, Doerte Hesse, Lennart Opitz, Uwe Plessmann, Henning Urlaub, Juan Jose Poderoso, Elizabeth A Jares-Erijman, Thomas M Jovin

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7541 (2009)

Extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) are members of the MAPK family and participate in the transduction of stimuli in cellular responses. Their long-term actions are accomplished by promoting the expression of specific genes

Externí odkaz: https://doaj.org/article/ed81a34d20d444358ff640a2637bd98e

A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells

Autor: Elizabeth A. Jares-Erijman, Olaf Jahn, Doerte Hesse, Uwe Plessmann, Reiner Hitt, Henning Urlaub, Soledad Galli, Juan José Poderoso, Thomas M. Jovin, Lennart Opitz

Publikováno v: PLoS ONE
PLoS ONE 2009;4(10)
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
PLoS One
PLoS ONE, Vol 4, Iss 10, p e7541 (2009)

Extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) are members of the MAPK family and participate in the transduction of stimuli in cellular responses. Their long-term actions are accomplished by promoting the expression of specific genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abaf7c5020b66c95676389c039c3e0e
https://pubmed.ncbi.nlm.nih.gov/19847302

Regulation of IL2 and NUCB1 in mononuclear cells treated with acyl glucuronide of mycophenolic acid reveals effects independent of inosine monophosphate dehydrogenase inhibition

Autor: Darinka Todorova Petrova, Victor W. Armstrong, Maria Shipkova, Tanja Heller, Michael Oellerich, Eberhard Wieland, Reiner Hitt

Publikováno v: Therapeutic drug monitoring. 31(1)

The aim of the present study was to investigate whether the acyl glucuronide of mycophenolic acid (AcMPAG) directly affects gene expression independent of guanosine (G) depletion. Human native mononuclear cells from healthy volunteers were studied. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cb0de4d98b670c3d865de557b7a429
https://pubmed.ncbi.nlm.nih.gov/19065122

DER7, encoding alpha-glucosidase I is essential for degradation of malfolded glycoproteins of the endoplasmic reticulum

Autor: Dieter H. Wolf, Reiner Hitt

Publikováno v: FEMS yeast research. 4(8)

Proteins entering the endoplasmic reticulum (ER) have to acquire an export-competent structure before they are delivered to their final destination. This folding process is monitored by an ER protein quality control system. Folding-incompetent confor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c69ac37773f2072ee3f9ebd6865346
https://pubmed.ncbi.nlm.nih.gov/15450188

Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD

Autor: Dieter H. Wolf, Peter M. Deak, Zlatka Kostova, Sae-Hun Park, Reiner Hitt, Christof Taxis

Publikováno v: The Journal of biological chemistry. 278(38)

The endoplasmic reticulum (ER) harbors a protein quality control system, which monitors protein folding in the ER. Elimination of malfolded proteins is an important function of this protein quality control. Earlier studies with various soluble and tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342d50492e899b0cd20e4dfbc28655ce
https://pubmed.ncbi.nlm.nih.gov/12847107