Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Reiner F. Haseloff"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5601 (2024)
This review addresses the role of tight junction proteins at the blood-brain barrier (BBB). Their expression is described, and their role in physiological and pathological processes at the BBB is discussed. Based on this, new approaches are depicted
Externí odkaz:
https://doaj.org/article/43d17f313ca94cf78c055f388dbc319a
Autor:
Ningjing Lei, Yanru Cheng, Jiajia Wan, Rosel Blasig, Anqi Li, Yueyue Bai, Reiner F. Haseloff, Ingolf E. Blasig, Linyu Zhu, Zhihai Qin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Claudin-3 is a tight junction protein that has often been associated with the progression and metastasis of various tumors. Here, the role of claudin-3 in tumor-induced lymphangiogenesis is investigated. We found an increased lymphangiogenes
Externí odkaz:
https://doaj.org/article/59ed644337784e4193efb81bc0cb0487
Autor:
Reiner F. Haseloff, Stephanie Trudel, Ramona Birke, Michael Schümann, Eberhard Krause, Cathy Gomila, Jean-Michel Heard, Ingolf E. Blasig, Jérôme Ausseil
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Mucopolysaccharidosis type I (MPS I) is caused by a deficiency of the lysosomal hydroxylase alpha-l-iduronidase (IDUA). The resulting accumulation of dermatan and heparan sulfate induces intellectual disabilities and pre-mature death, and only a few
Externí odkaz:
https://doaj.org/article/ce0c544621ed42069de208e4428cd9a5
Autor:
Reiner F. Haseloff, Giovanna del Vecchio, Christian Tscheik, Sophie Dithmer, Wolfgang Walther, Olga Breitkreuz-Korff, Leif Schröder, Lars Winkler, Hartwig Wolburg, Ingolf E. Blasig, Andrea Orthmann
Publikováno v:
Journal of Controlled Release. 338:137-148
Drug delivery to the brain is limited for most pharmaceuticals by the blood-brain barrier (BBB) where claudin-5 dominates the paraendothelial tightening. For circumventing the BBB, we identified the compound M01 as a claudin-5 interaction inhibitor.
Autor:
Nora Gehne, Agathe Lamik, Martin Lehmann, Reiner F Haseloff, Anuska V Andjelkovic, Ingolf E Blasig
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182106 (2017)
Claudins (Cldns) are transmembrane tight junction (TJ) proteins that paracellularly seal endo- and epithelial barriers by their interactions within the TJs. However, the mechanisms allowing TJ remodeling while maintaining barrier integrity are largel
Externí odkaz:
https://doaj.org/article/c5dd8d5b83f64b70909284dea88b1471
Autor:
Ingolf E. Blasig, Philipp Berndt, Rosel Blasig, Sophie Dithmer, Reiner F. Haseloff, Hartwig Wolburg, Lars Winkler, Valentina Rausch, Olga Breitkreuz-Korff, Anje Sporbert, André Rex, Jimmi Cording, Matthias Richter
Publikováno v:
Cellular and Molecular Life Sciences. 76:1987-2002
At the blood-brain barrier (BBB), claudin (Cldn)-5 is thought to be the dominant tight junction (TJ) protein, with minor contributions from Cldn3 and -12, and occludin. However, the BBB appears ultrastructurally normal in Cldn5 knock-out mice, sugges
Autor:
Hartwig Wolburg, Dmytro Puchkov, Stefan Liebner, Ingolf E. Blasig, Rosel Blasig, Philipp Berndt, Kavi Devraj, Sophie Dithmer, Anuska V. Andjelkovic, Olga Breitkreuz-Korff, Reiner F. Haseloff, Hans Christian Cederberg Helms, André Rex, Zhihai Qin, Mehmet Kaya, Lars Winkler
Publikováno v:
J Cereb Blood Flow Metab
The outcome of stroke is greatly influenced by the state of the blood–brain barrier (BBB). The BBB endothelium is sealed paracellularly by tight junction (TJ) proteins, i.e., claudins (Cldns) and the redox regulator occludin. Functions of Cldn3 and
Autor:
Philipp Berndt, Lars Winkler, Ingolf E. Blasig, Anneliese Krüger, Jimmi Cording, Basak Arslan, Ramona Günther, Susanne M. Krug, Reiner F. Haseloff, Christian Staat, Sophie Dithmer
Publikováno v:
Annals of the New York Academy of Sciences. 1405:89-101
The majority of tight junction (TJ) proteins restrict the paracellular permeation of solutes via their extracellular loops (ECLs). Tricellulin tightens tricellular TJs (tTJs) and regulates bicellular TJ (bTJ) proteins. We demonstrate that the additio
Autor:
Thoralf Niendorf, Ingolf E. Blasig, Nora Gehne, Andreas Pohlmann, Petra Fallier-Becker, Mária A. Deli, Lars Winkler, Christian Staat, Fruzsina R. Walter, Min Chi Ku, Ágnes Kittel, Rosel Blasig, Reiner F. Haseloff, Szilvia Veszelka, Sophie Dithmer, Carolin Müller
Publikováno v:
Annals of the New York Academy of Sciences. 1397:169-184
The blood–brain barrier (BBB) formed by the microvascular endothelium limits cerebral drug delivery. The paraendothelial cleft is sealed by tight junctions (TJs) with a major contribution from claudin-5, which we selected as a target to modulate BB
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2044
Molecular analysis of cerebrospinal fluid (CSF) provides comprehensive information on physiological and pathological processes related to the brain. In particular, proteomic studies give insights into the pathogenesis of many brain diseases which sti