Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options.

Autor: Corley C; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA., Craig A; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA., Sadek S; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA., Marusich JA; RTI International, Research Triangle Park, NC, USA., Chehimi SN; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., White AM; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA., Holdiness LJ; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA., Reiner BC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gipson CD; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA. Electronic address: cdgips2@uky.edu.

Publikováno v: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2024 Oct; Vol. 243, pp. 173836. Date of Electronic Publication: 2024 Jul 26.

A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens.

Autor: Reiner BC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chehimi SN; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Merkel R; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, USA., Toikumo S; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Berrettini WH; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kranzler HR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA., Sanchez-Roige S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Institute for Genomic Medicine, University of California San Diego, San Diego, CA, USA., Kember RL; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA., Schmidt HD; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, USA., Crist RC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 125 South 31st Street, Room 2207, Philadelphia, PA, 19104, USA. crist@pennmedicine.upenn.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Aug 06; Vol. 14 (1), pp. 18258. Date of Electronic Publication: 2024 Aug 06.

Single-nucleus RNA-seq identifies one galanin neuronal subtype in mouse preoptic hypothalamus activated during recovery from sleep deprivation.

Autor: Guo X; Circadian Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Keenan BT; Circadian Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Reiner BC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lian J; Circadian Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pack AI; Circadian Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: pack@pennmedicine.upenn.edu.

Publikováno v: Cell reports [Cell Rep] 2024 May 28; Vol. 43 (5), pp. 114192. Date of Electronic Publication: 2024 May 03.

Mimicking opioid analgesia in cortical pain circuits.

Autor: James JG; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., McCall NM; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hsu AI; Dept. of Biobehavioral Health Sciences, School of Nursing, and Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Dept. of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA., Oswell CS; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Salimando GJ; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mahmood M; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wooldridge LM; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wachira M; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Jo A; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sandoval Ortega RA; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wojick JA; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Beattie K; Dept. of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Farinas SA; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chehimi SN; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rodrigues A; Dept. of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ejoh LL; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kimmey BA; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lo E; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Azouz G; Dept. of Physiology and Biophysics, University of California Irvine, CA, USA., Vasquez JJ; Dept. of Physiology and Biophysics, University of California Irvine, CA, USA., Banghart MR; Dept. of Neurobiology, School of Biological Sciences, University of California San Diego, CA, USA., Creasy KT; Dept. of Biobehavioral Health Sciences, School of Nursing, and Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Beier KT; Dept. of Physiology and Biophysics, University of California Irvine, CA, USA., Ramakrishnan C; CNC Program, Stanford University, Stanford, CA, USA., Crist RC; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Reiner BC; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Deisseroth K; CNC Program, Stanford University, Stanford, CA, USA.; Dept. of Bioengineering, Stanford University, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.; Dept. of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, USA., Yttri EA; Dept. of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA., Corder G; Dept. of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Dept. of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Dept. of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 29. Date of Electronic Publication: 2024 Apr 29.

Calcitonin receptor signaling in nucleus accumbens D1R- and D2R-expressing medium spiny neurons bidirectionally alters opioid taking in male rats.

Autor: Zhang Y; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Ben Nathan J; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Moreno A; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Merkel R; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Kahng MW; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Hayes MR; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Reiner BC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Crist RC; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Schmidt HD; Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA, 19104, USA. hschmidt@nursing.upenn.edu.; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. hschmidt@nursing.upenn.edu.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2023 Dec; Vol. 48 (13), pp. 1878-1888. Date of Electronic Publication: 2023 Jun 24.