Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain.

Autor: Stefano Suzzi, Reiner Ahrendt, Stefan Hans, Svetlana A Semenova, Avinash Chekuru, Paul Wirsching, Volker Kroehne, Saygın Bilican, Shady Sayed, Sylke Winkler, Sandra Spieß, Anja Machate, Jan Kaslin, Pertti Panula, Michael Brand

Publikováno v: PLoS Genetics, Vol 17, Iss 9, p e1009794 (2021)

LRRK2 gain-of-function is considered a major cause of Parkinson's disease (PD) in humans. However, pathogenicity of LRRK2 loss-of-function in animal models is controversial. Here we show that deletion of the entire zebrafish lrrk2 locus elicits a ple

Externí odkaz: https://doaj.org/article/66a7d68b5aa74d34a2b220b852048894

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Regional performance variation in external validation of four prediction models for severity of COVID-19 at hospital admission: An observational multi-centre cohort study.

Autor: Wickstrøm KE; Department of Medical Biochemistry, Blood Cell Research Group, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Vitelli V; Oslo Centre for Biostatistics and Epidemiology, Faculty of Medicine, University of Oslo, Oslo, Norway., Carr E; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Holten AR; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Acute Medicine, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Bendayan R; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, United Kingdom., Reiner AH; Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway., Bean D; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; Health Data Research UK London, University College London, London, United Kingdom., Searle T; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, United Kingdom., Shek A; Department of Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Kraljevic Z; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Teo J; Department of Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; King's College Hospital NHS Foundation Trust, London, United Kingdom., Dobson R; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, United Kingdom.; Health Data Research UK London, University College London, London, United Kingdom.; Institute of Health Informatics, University College London, London, United Kingdom.; NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust, London, United Kingdom., Tonby K; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway., Köhn-Luque A; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Amundsen EK; Department of Medical Biochemistry, Blood Cell Research Group, Oslo University Hospital, Oslo, Norway.; Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway.

Publikováno v: PloS one [PLoS One] 2021 Aug 25; Vol. 16 (8), pp. e0255748. Date of Electronic Publication: 2021 Aug 25 (Print Publication: 2021).

A Bayesian mixed modeling approach for estimating heritability.

Autor: Nustad HE; 1Department of Medical Genetics, Oslo University Hospital, Kirkeveien 166, 0450 Oslo, Norway.; 2Department of Medical Genetics, University of Oslo, Klaus Torgårds vei 3, 0372 Oslo, Norway.; 3PharmaTox Strategic Research Initiative, University of Oslo, Sem Sælands vei 3, 0371 Oslo, Norway., Page CM; 4Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Klaus Torgårds vei 3, 0372 Oslo, Norway.; 5Department of Non-Communicable Disease, Norwegian Institute of Public Health, Marcus Thranes gate 6, 0473 Oslo, Norway., Reiner AH; 4Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Klaus Torgårds vei 3, 0372 Oslo, Norway., Zucknick M; 6Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Sognsvannsveien 9, 0372 Oslo, Norway., LeBlanc M; 4Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Klaus Torgårds vei 3, 0372 Oslo, Norway.

Publikováno v: BMC proceedings [BMC Proc] 2018 Sep 17; Vol. 12 (Suppl 9), pp. 31. Date of Electronic Publication: 2018 Sep 17 (Print Publication: 2018).

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells.

Autor: El Taghdouini A; Liver Cell Biology Lab, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Sørensen AL; Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway., Reiner AH; Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway., Coll M; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Verhulst S; Liver Cell Biology Lab, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Mannaerts I; Liver Cell Biology Lab, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Øie CI; Department of Medical Biology, Vascular Biology Research Group, UiT, The Arctic University of Norway, Tromsø, Norway., Smedsrød B; Department of Medical Biology, Vascular Biology Research Group, UiT, The Arctic University of Norway, Tromsø, Norway., Najimi M; Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium., Sokal E; Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium., Luttun A; Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium., Sancho-Bru P; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Collas P; Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway., van Grunsven LA; Liver Cell Biology Lab, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Publikováno v: Oncotarget [Oncotarget] 2015 Sep 29; Vol. 6 (29), pp. 26729-45.