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Microphysiological heart–liver body-on-a-chip system with a skin mimic for evaluating topical drug delivery

Autor: Camilly P. Pires de Mello, Carlos Carmona-Moran, Christopher W. McAleer, Julian Perez, Elizabeth A. Coln, Christopher J. Long, Carlota Oleaga, Anne Riu, Reine Note, Silvia Teissier, Jessica Langer, James J. Hickman

Publikováno v: Lab Chip

Body-on-a-chip in vitro systems are a promising technology that aims to increase the predictive power of drug efficacy and toxicity in humans when compared to traditional animal models. Here, we developed a new heart-liver body-on-a-chip system with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd99dfc816c65003bd4885bcce6c968
https://doi.org/10.1039/c9lc00861f

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Microphysiological flux balance platform unravels the dynamics of drug induced steatosis

Autor: Avner Ehrlich, Sabina Tsytkin-Kirschenzweig, Konstantinos Ioannidis, Muneef Ayyash, Anne Riu, Reine Note, Gladys Ouedraogo, Jan Vanfleteren, Merav Cohen, Yaakov Nahmias

Publikováno v: Lab on a Chip

Drug development is currently hampered by the inability of animal experiments to accurately predict human response. While emerging organ on chip technology offers to reduce risk using microfluidic models of human tissues, the technology still mostly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8749b4d8113997869c230f70cf2c468d

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Mitochondrial and Metabolic Effects of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in Mice Receiving One of Five Single- and Three Dual-NRTI Treatments

Autor: Reine Note, Caroline Maisonneuve, Philippe Lettéron, Gilles Peytavin, Fatima Djouadi, Anissa Igoudjil, Marie-Christine Guimont, Michel Biour, Dominique Pessayre, Bernard Fromenty

Publikováno v: Antimicrobial Agents and Chemotherapy. 47:3384-3392

Although treatments with nucleoside reverse transcriptase inhibitors (NRTIs) can modify fat metabolism and fat distribution in humans, the mechanisms of these modifications and the roles of diverse NRTIs are unknown. We studied the mitochondrial and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8040ab5f843b878ed97162e90e47c886
https://doi.org/10.1128/aac.47.11.3384-3392.2003

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Synthesis and Evaluation of 'AZT-HEPT', 'AZT-Pyridinone', and 'ddC-HEPT' Conjugates as Inhibitors of HIV Reverse Transcriptase

Autor: Renée Pontikis, Valérie Dollé, Jean Guillaumel, Elsa Dechaux, Reine Note, Chi Hung Nguyen, Michel Legraverend, Emile Bisagni, Anne-Marie Aubertin, David S. Grierson, Claude Monneret

Publikováno v: Journal of Medicinal Chemistry. 43:1927-1939

To test the concept that HIV reverse transcriptase could be effectively inhibited by "mixed site inhibitors", a series of seven conjugates containing both a nucleoside analogue component (AZT 1, ddC 2) and a nonnucleoside type inhibitor (HEPT analogu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bf6226eca8e8aebfb4b359afe7bd40
https://doi.org/10.1021/jm991125l

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Development of a mechanistic SAR model for the detection of phototoxic chemicals and use in an integrated testing strategy

Autor: Stephanie Ringeissen, Laurent Marrot, Reine Note, Anita Labarussiat, Stéphane Imbert, Milen Todorov, Ovanes Mekenyan, Jean-Roch Meunier

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 25(1)

Phototoxicity is of increasing concern in dermatology, since modern lifestyle is often associated with exposure to sunlight. The most commonly reported process is via oxidative reactions. Therefore characterizing the "photo-pro-oxidant" potential of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0b5d52a5eaa7711323721d527898e7
https://pubmed.ncbi.nlm.nih.gov/20932893

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