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Autor:
Zhangping, Xiao, Angelina, Osipyan, Shanshan, Song, Deng, Chen, Reinder A, Schut, Ronald, van Merkerk, Petra E, van der Wouden, Robbert H, Cool, Wim J, Quax, Barbro N, Melgert, Gerrit J, Poelarends, Frank J, Dekker
Publikováno v:
Journal of medicinal chemistry. 65(3)
The homologous cytokines macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT or MIF2) play key roles in cancers. Molecules binding to the MIF tautomerase active site interfere with its biological activity. In contrast, the