Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Reinaldo Jones"'
Autor:
Momar Toure, Constantin Neagu, Kevin Ho, Susan Zhang, Filippos Porichis, Zhizhou Fang, Maria DiPoto, Reinaldo Jones, Eugene Chekler, Eva Maria Tanzer, Brian Sherer, Theresa Johnson, Djordje Musil, Bin Li, Ralf Schmidt, Hong Ma, Andrea Unzue Lopez, Yanping Wang, Satenig Guler, YuFang Xiao, Renate Henkes, Chia Lin Chu, Uma Mahesh Gundra, Long Li, Christine Katharina Maurer, Emily Friis, Christopher Jones, James Cummings, Bayard Huck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60c4b42c55d861e189da387afa4d82a1
https://doi.org/10.2139/ssrn.4382746
https://doi.org/10.2139/ssrn.4382746
Autor:
Brian H. Heasley, Jing Lin, Thomas F. N. Haxell, Igor Mochalkin, Constantin Neagu, Felix Rohdich, Ruoxi Lan, Amanda E. Sutton, Jennifer Jackson, Potnick Justin, Bayard R. Huck, Andreas Machl, Katrin Georgi, Xiaoling Chen, Sherer Brian A, Erik Wilker, Thomas E. Richardson, Anderson Clark, Reinaldo Jones, Johnson Theresa L, Lizbeth Celeste Deselm, Andreas Goutopoulos, Hui Tian, Yufang Xiao, Joseph A. Moore, Lindsey Crowley
Publikováno v:
Journal of Medicinal Chemistry. 64:14603-14619
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0f668e1b7d0d3fdf120a40211a6894
https://doi.org/10.1021/acs.jmedchem.1c01087
https://doi.org/10.1021/acs.jmedchem.1c01087
Autor:
Alexander Steiner, Johannes Krieger, Reinaldo Jones, Dietrich Böse, Yanping Wang, Hans‐Michael Eggenweiler, Jason D. Williams, C. Oliver Kappe
Publikováno v:
ChemCatChem. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf3532591585815e00dde8ff269dc7f4
https://doi.org/10.1002/cctc.202201184
https://doi.org/10.1002/cctc.202201184
Autor:
Dusica Cvetinovic Santos, Klaus Urbahns, Simone C. Zimmerli, Andreas Goutopoulos, Justin R. Potnick, Andrew Bender, Michael Meyring, Adam Shutes, Christopher Charles Victor Jones, Jared Head, Ben C. Askew, Bayard R. Huck, Ansgar Wegener, Hui Qiu, Theresa L. Johnson, Nadia Brugger, Sherer Brian A, Ngan Nguyen, Mohanraj Dhanabal, Ralf Schmidt, Roland Grenningloh, Reinaldo Jones, Richard D. Caldwell, Ariele Viacava Follis, Brian Healey, Montserrat Camps, Igor Mochalkin, Federica Morandi, Lesley Liu-Bujalski, Vikram Dutt, Brian L. Hodous, Anna Gardberg, Thomas Eichhorn
Publikováno v:
Journal of Medicinal Chemistry. 62:7643-7655
Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib hold a prominent role in the treatment of B cell malignancies. However, further refinement is needed to this class of agents, particularly in terms of adverse events (potentially driven by k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb51d59d700ed35c9b5eb75576ca2e2d
https://doi.org/10.1021/acs.jmedchem.9b00794
https://doi.org/10.1021/acs.jmedchem.9b00794
Autor:
Andrew Bender, Anna Gardberg, Lesley Liu-Bujalski, Jared Head, Igor Mochalkin, Potnick Justin, Johnson Theresa L, Federica Morandi, Roland Grenningloh, Richard D. Caldwell, Reinaldo Jones, Ariele Viacava Follis, Hui Qiu, Andreas Goutopoulos, Daigen Xu, Sherer Brian A
Publikováno v:
ChemMedChem. 14:217-223
Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small-molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f5fa08a314bbf9e58760306ecdf58d
https://doi.org/10.1002/cmdc.201800714
https://doi.org/10.1002/cmdc.201800714
Autor:
Constantin Neagu, Johnson Theresa L, Federica Morandi, Sherer Brian A, Roland Grenningloh, Jared Head, Reinaldo Jones, Hui Qiu, Andreas Goutopoulos, Anna Gardberg, Lesley Liu-Bujalski, Igor Mochalkin, Ariele Viacava Follis, Richard D. Caldwell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3419-3424
Btk is an attractive target for the treatment of a range of Bcell malignancies as well as several autoimmune diseases such as murine lupus and rheumatoid arthritis. Several covalent irreversible inhibitors of Btk are currently in development includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea41e0e5e139c277b6c3ead12456930b
https://doi.org/10.1016/j.bmcl.2018.09.033
https://doi.org/10.1016/j.bmcl.2018.09.033
Autor:
Anna Gardberg, Federica Morandi, Katherine Roe, Carolyn Wing, Andreas Goutopoulos, Richard D. Caldwell, Johnson Theresa L, Yi-Ying Chen, Constantin Neagu, Shashank Kulkarni, Ralf Schmidt, Roland Grenningloh, Sherer Brian A, Sven Poetzsch, Andrew Bender, Anja Goettsche, Nina Glaser, Christopher Charles Victor Jones, Xiaohua Zhu, Zahid Ali, Jared Head, Zhizhou Fang, Christine Maurer, Ariele Viacava Follis, Potnick Justin, Reinaldo Jones, Hui Qiu, Bettina Hanschke
Publikováno v:
Bioorganic & Medicinal Chemistry. 40:116163
Bruton’s tyrosine kinase (BTK) is a cytoplasmic, non-receptor tyrosine kinase member of the TEC family of tyrosine kinases. Pre-clinical and clinical data have shown that targeting BTK can be used for the treatment for B-cell disorders. Here we dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103ce6c76a17a7f47605d995d247a29b
https://doi.org/10.1016/j.bmc.2021.116163
https://doi.org/10.1016/j.bmc.2021.116163
Autor:
Jared Head, Federica Morandi, Roland Grenningloh, Andreas Goutopoulos, Anna Gardberg, Lesley Liu-Bujalski, Constantin Neagu, Reinaldo Jones, Hui Qiu, Sherer Brian A, Johnson Theresa L, Richard D. Caldwell, Ariele Viacava Follis, Igor Mochalkin
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(17)
Bruton's Tyrosine Kinase (BTK) is a member of the TEC kinase family that is expressed in cells of hematopoietic lineage (e.g., in B cells, macrophages, monocytes, and mast cells). Small molecule covalent irreversible BTK inhibitor targeting Cys481 wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196d34051cf8d3615a0a6fde6fb3a7d3
https://pubmed.ncbi.nlm.nih.gov/30122225
https://pubmed.ncbi.nlm.nih.gov/30122225
Autor:
Mikhail Kagan, Carol Hui Hu, Thomas D. Harris, Megan Hayes, Padmaja Yalamanchili, Kelley Hanson, Ming Yu, Michael Azure, Ajay Purohit, Simon P. Robinson, Reinaldo Jones, Michael Cdebaca, Mary Guaraldi, Radeke Heike S, David S. Casebier
Publikováno v:
ACS Medicinal Chemistry Letters. 2:650-655
A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats. Tissue distribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011363cd3addeb5ca8b13c5c85c2939e
https://doi.org/10.1021/ml1002458
https://doi.org/10.1021/ml1002458
Autor:
David S. Casebier, Greg Dwyer, Cesati Rr rd, Padmaja Yalamanchili, Reinaldo Jones, Megan Hayes
Publikováno v:
Organic Letters. 9:5617-5620
Recently developed copper-catalyzed coupling methodology has been applied to the synthesis of amino acid derived enamides. Bond formation proved to be strongly influenced by protection strategy and vinyl iodide substitution while tolerant of limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c370f8e4898a8a8e6a48ec3d9a43c5f
https://doi.org/10.1021/ol7025729
https://doi.org/10.1021/ol7025729