Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Reina Improgo"'
Autor:
Jennifer R. Brown, Sunita R. Setlur, Gad Getz, Charles Lee, Josephine L. Klitgaard, Saranya Radhakrishnan, Stacey M. Fernandes, Reina Improgo, Bethany Tesar, Andrew Aw, Kevin Hoang, Wei Du, Parul Benien, Siddha N. Kasar, Haesook T. Kim, Lijian Yu
Table S1. Minimally deleted regions (MDR) of recurrent deletions. Table S2. Clinical features of the patients in this study. Table S3. Overall survival is correlated with total copy number events and somatic mutations. Table S4. Details of the RPS15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f14ba1af0279d843c81f86abbdcf719
https://doi.org/10.1158/1078-0432.22464900
https://doi.org/10.1158/1078-0432.22464900
Autor:
Jeffrey R Simard, Trang N. Tieu, Eunice Park, Ellen F. Vieux, Andrew J. K. Phillips, Reina Improgo, Stewart L. Fisher, Linda Lee, Roy M. Pollock
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(4)
The aberrant regulation of protein expression and function can drastically alter cellular physiology and lead to numerous pathophysiological conditions such as cancer, inflammatory diseases, and neurodegeneration. The steady-state expression levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b097c45eab0e0959b805ed8d686393
https://pubmed.ncbi.nlm.nih.gov/33430712
https://pubmed.ncbi.nlm.nih.gov/33430712
Autor:
Jennifer R. Brown, Saranya Radhakrishnan, Sunita R. Setlur, Reina Improgo, Lijian Yu, Gad Getz, Kevin Hoang, Parul Benien, Stacey M. Fernandes, Charles Lee, Josephine L. Klitgaard, Haesook T. Kim, Bethany Tesar, Siddha Kasar, Wei Du, Andrew Aw
Publikováno v:
Clinical Cancer Research. 23:735-745
Purpose: Chronic lymphocytic leukemia (CLL) with 17p deletion typically progresses quickly and is refractory to most conventional therapies. However, some del(17p) patients do not progress for years, suggesting that del(17p) is not the only driving e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787d0080f31b257c889de09e56f29ae6
https://doi.org/10.1158/1078-0432.ccr-16-0594
https://doi.org/10.1158/1078-0432.ccr-16-0594
Autor:
Jennifer R. Brown, Divya Chaudhary, Bethany Tesar, Haesook T. Kim, Stacey M. Fernandes, Reuma Magori-Cohen, Lijian Yu, William F. Westlin, Siddha Kasar, Kevin Hoang, Ma. Reina Improgo, Wenyan Miao, Josephine L. Klitgaard
Publikováno v:
British Journal of Haematology.
The L265P somatic mutation in the Myeloid Differentiation Primary Response 88 (MYD88) gene is a recurrent mutation in chronic lymphocytic leukaemia (CLL). This mutation has functional effects in various haematological malignancies but its role in CLL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd6220203b80bbed67ad8303952f94b
https://doi.org/10.1111/bjh.15714
https://doi.org/10.1111/bjh.15714
Autor:
Stacey M. Fernandes, Adam Kiezun, Catherine J. Wu, Samira Bahl, Eric S. Lander, Sandra Robrecht, Atanas Kamburov, Eugen Tausch, Esther Rheinbay, Haesook T. Kim, Dan-Avi Landau, Siddha Kasar, Ma. Reina Improgo, Grace Tiao, Jennifer R. Brown, Weijie Poh, Gad Getz, Kevin Hoang, Jasmin Bahlo, Amaro Taylor-Weiner, Stephan Stilgenbauer, Carrie Cibulskis, Kirsten Fischer, Stacey Gabriel, Michael Hallek
Publikováno v:
Leukemia
Chronic lymphocytic leukemia (CLL) is a highly heritable cancer, with a 7.5-fold increased risk in first-degree relatives.1 However, inherited predisposition to CLL remains largely unexplained by traditional linkage or genome-wide association studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e858bee9c00e9a55005b21604da437
https://pubmed.ncbi.nlm.nih.gov/28652578
https://pubmed.ncbi.nlm.nih.gov/28652578
Autor:
Jennifer R. Brown, Ma. Reina Improgo
Publikováno v:
Hematology/Oncology Clinics of North America. 27:157-171
This article discusses recent advances in genomic approaches used to understand chronic lymphocytic leukemia (CLL). We describe tools for analyzing DNA sequence level alterations, summarize data obtained from these various platforms, and discuss the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4628ad9592930e5a808db728c2e5b1
https://doi.org/10.1016/j.hoc.2013.01.001
https://doi.org/10.1016/j.hoc.2013.01.001
Autor:
Eugen Tausch, Jasmin Bahlo, Gad Getz, Grace Tiao, Stacey M. Fernandes, Jennifer R. Brown, Stephan Stilgenbauer, M. Reina Improgo, Kirsten Fischer, Michael Hallek, Sandra Robrecht, Adam Kiezun
Publikováno v:
Blood. 130:2443-2444
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2708bf2c3a6c174a33f7a00914ced9
https://doi.org/10.1182/blood-2017-08-800128
https://doi.org/10.1182/blood-2017-08-800128
Autor:
Irene M. Ghobrial, Mick Correll, Jorge J. Castillo, Ma. Reina Improgo, Luisa Imberti, Jiantao Shi, Eliezer M. Van Allen, Jennifer R. Brown, Salomon Manier, Yawara Kawano, Adriana Perilla-Glen, Giuseppe Rossi, Yosra Aljawai, Antonio Sacco, Marco Chiarini, Michele Moschetta, Siobhan Glavey, Aldo M. Roccaro, Winston Hide, Matthew L. Freedman, Irene Rainville, Elaine Hiller, Steven P. Treon, Yuji Mishima
Publikováno v:
Blood. 127(21)
Familial aggregation of Waldenstrom macroglobulinemia (WM) cases, and the clustering of B-cell lymphoproliferative disorders among first-degree relatives of WM patients, has been reported. Nevertheless, the possible contribution of inherited suscepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8ec34ea23e94c3cc4724584d427b05
https://pubmed.ncbi.nlm.nih.gov/26903547
https://pubmed.ncbi.nlm.nih.gov/26903547
Autor:
Haesook T. Kim, Lijian Yu, Jennifer R. Brown, Kevin Hoang, William F. Westlin, Stacey M. Fernandes, Bethany Tesar, Reuma Magori-Cohen, Reina Improgo, Wenyan Miao, Josephine L. Klitgaard, Divya Chaudhary
Publikováno v:
Blood. 126:491-491
The L265P somatic mutation in the Myeloid Differentiation Primary Response 88 (MYD88) gene is recurrently observed in CLL; although this mutation has been demonstrated to have functional effects in multiple hematologic malignancies, its role in CLL i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff3382ea8afcc9104dec98e252a6b4de
https://doi.org/10.1182/blood.v126.23.491.491
https://doi.org/10.1182/blood.v126.23.491.491
Autor:
Wei Du, Charles Lee, Josephine L. Klitgaard, Lijian Yu, Parul Benien, Jennifer R. Brown, Reina Improgo, Stacey M. Fernandes, Gady Getz, Haesook T. Kim, Sunita R. Setlur, Siddha Kasar, Kevin Hoang
Publikováno v:
Blood. 126:2907-2907
Many studies have shown that deletion at chromosome 17p targeting the TP53 gene, or del(17p), is associated with poor prognosis in chronic lymphocytic leukemia (CLL). Despite this, not all del(17p) CLL progresses rapidly to treatment and has short su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::702b65757ff6230ced8ffe4a1093033e
https://doi.org/10.1182/blood.v126.23.2907.2907
https://doi.org/10.1182/blood.v126.23.2907.2907