Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rein I. Hoogstraaten"'
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100325- (2021)
Summary: Neuropeptides are essential signaling molecules secreted by dense-core vesicles (DCVs). They contribute to information processing in the brain, controlling a variety of physiological conditions. Defective neuropeptide signaling is implicated
Externí odkaz:
https://doaj.org/article/c4be119d56b24cecb2bb144800b46d49
Autor:
Adlin Abramian, Rein I Hoogstraaten, Fiona H Murphy, Kathryn F McDaniel, Ruud F Toonen, Matthijs Verhage
Publikováno v:
eLife, Vol 13 (2024)
Neuropeptides and neurotrophins are stored in and released from dense core vesicles (DCVs). While DCVs and synaptic vesicles (SVs) share fundamental SNARE/SM proteins for exocytosis, a detailed understanding of DCV exocytosis remains elusive. We rece
Externí odkaz:
https://doaj.org/article/8df4ba1466d64e7c88f641f81fa7540e
Publikováno v:
Scientific Reports
Scientific Reports, 10(1):10913. Nature Publishing Group
Hoogstraaten, R I, van Keimpema, L, Toonen, R F & Verhage, M 2020, ' Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons ', Scientific Reports, vol. 10, no. 1, 10913, pp. 1-14 . https://doi.org/10.1038/s41598-020-67988-2
Scientific Reports, 10(1):10913, 1-14. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Hoogstraaten, R I, van Keimpema, L, Toonen, R F & Verhage, M 2020, ' Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons ', Scientific Reports, vol. 10, no. 1, 10913 . https://doi.org/10.1038/s41598-020-67988-2
Scientific Reports, 10(1):10913. Nature Publishing Group
Hoogstraaten, R I, van Keimpema, L, Toonen, R F & Verhage, M 2020, ' Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons ', Scientific Reports, vol. 10, no. 1, 10913, pp. 1-14 . https://doi.org/10.1038/s41598-020-67988-2
Scientific Reports, 10(1):10913, 1-14. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Hoogstraaten, R I, van Keimpema, L, Toonen, R F & Verhage, M 2020, ' Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons ', Scientific Reports, vol. 10, no. 1, 10913 . https://doi.org/10.1038/s41598-020-67988-2
The SNARE proteins involved in the secretion of neuromodulators from dense core vesicles (DCVs) in mammalian neurons are still poorly characterized. Here we use tetanus neurotoxin (TeNT) light chain, which cleaves VAMP1, 2 and 3, to study DCV fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ab1b888123a226f814714ada98cb64
http://europepmc.org/articles/PMC7331729
http://europepmc.org/articles/PMC7331729
Autor:
Pascal S. Kaeser, Ruud F. Toonen, Claudia M. Persoon, Rein I. Hoogstraaten, Jan R.T. van Weering, Matthijs Verhage, Joris Paul Nassal
Publikováno v:
Neuron, 104(6), 1065-1080.e12. Cell Press
Persoon, C M, Hoogstraaten, R I, Nassal, J P, van Weering, J R T, Kaeser, P S, Toonen, R F & Verhage, M 2019, ' The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators ', Neuron, vol. 104, no. 6, pp. 1065-1080.e12 . https://doi.org/10.1016/j.neuron.2019.09.015
Neuron
Persoon, C M, Hoogstraaten, R I, Nassal, J P, van Weering, J R T, Kaeser, P S, Toonen, R F & Verhage, M 2019, ' The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators ', Neuron, vol. 104, no. 6, pp. 1065-1080.e12 . https://doi.org/10.1016/j.neuron.2019.09.015
Neuron
Secretion principles are conserved from yeast to humans, and many yeast orthologs have established roles in synaptic vesicle exocytosis in the mammalian brain. Surprisingly, SEC4 orthologs and their effectors, the exocyst, are dispensable for synapti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7daa4da9a3160a9d5332a9386cd01403
https://research.vu.nl/en/publications/247a3901-d785-43da-a2a0-94bde6468db9
https://research.vu.nl/en/publications/247a3901-d785-43da-a2a0-94bde6468db9
