Treatment with the dual-incretin agonist DA-CH5 demonstrates potent therapeutic effect in a rat model of Wolfram Syndrome.

Autor: Jagomäe T; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Gaur N; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Seppa K; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Reimets R; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Pastak M; Eye Clinic of Tartu University Hospital, Tartu, Estonia., Plaas M; Ear Clinic of Tartu University Hospital, Tartu, Estonia., Kaasik A; Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Vasar E; Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Plaas M; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

Publikováno v: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Oct 13; Vol. 14, pp. 1234925. Date of Electronic Publication: 2023 Oct 13 (Print Publication: 2023).

Early Intervention and Lifelong Treatment with GLP1 Receptor Agonist Liraglutide in a Wolfram Syndrome Rat Model with an Emphasis on Visual Neurodegeneration, Sensorineural Hearing Loss and Diabetic Phenotype.

Autor: Jagomäe T; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.; Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia., Seppa K; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia., Reimets R; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia., Pastak M; Eye Clinic of Tartu University Hospital, L. Puusepa 8 Street, 50406 Tartu, Estonia., Plaas M; Ear Clinic of Tartu University Hospital, L. Puusepa 1a Street, 50406 Tartu, Estonia., Hickey MA; Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia., Kukker KG; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia., Moons L; Research Group Neural Circuit Development and Regeneration, Department of Biology, Belgium & Leuven Brain Institute, University of Leuven, Naamsestraat 61, Box 2464, 3000 Leuven, Belgium., De Groef L; Research Group Neural Circuit Development and Regeneration, Department of Biology, Belgium & Leuven Brain Institute, University of Leuven, Naamsestraat 61, Box 2464, 3000 Leuven, Belgium., Vasar E; Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia., Kaasik A; Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia., Terasmaa A; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia., Plaas M; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.; Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.

Publikováno v: Cells [Cells] 2021 Nov 16; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 16.

High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice.

Autor: Kaare M; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Mikheim K; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Lilleväli K; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Kilk K; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.; Institute of Biomedicine and Translational Medicine, Department of Biochemistry, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia., Jagomäe T; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.; Institute of Biomedicine and Translational Medicine, Laboratory Animal Center, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia., Leidmaa E; Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, 53129 Bonn, Germany., Piirsalu M; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Porosk R; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.; Institute of Biomedicine and Translational Medicine, Department of Biochemistry, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia., Singh K; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Reimets R; Institute of Biomedicine and Translational Medicine, Laboratory Animal Center, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia., Taalberg E; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.; Institute of Biomedicine and Translational Medicine, Department of Biochemistry, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia., Schäfer MKE; Department of Anesthesiology, Focus Program Translational Neurosciences, Research Center for Immunotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany., Plaas M; Institute of Biomedicine and Translational Medicine, Laboratory Animal Center, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia., Vasar E; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Philips MA; Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.; Center of Excellence in Genomics and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.

Publikováno v: Biomedicines [Biomedicines] 2021 Sep 03; Vol. 9 (9). Date of Electronic Publication: 2021 Sep 03.

Wfs1-deficient animals have brain-region-specific changes of Na + , K + -ATPase activity and mRNA expression of α 1 and β 1 subunits

Autor: Sütt, S., Altpere, A., Reimets, R., Visnapuu, T., Loomets, M., Raud, S., Salum, T., Mahlapuu, R., Kairane, C., Zilmer, M., Vasar, E.

Publikováno v: Journal of Neuroscience Research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f88220598257f99e5992f2f597cbeb96

A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome.

Autor: Ahuja, K.^1,2,3 (AUTHOR), Vandenabeele, M.^1,2 (AUTHOR), Nami, F.³ (AUTHOR), Lefevere, E.¹ (AUTHOR), Van hoecke, J.¹ (AUTHOR), Bergmans, S.² (AUTHOR), Claes, M.¹ (AUTHOR), Vervliet, T.⁴ (AUTHOR), Neyrinck, K.³ (AUTHOR), Burg, T.^5,6 (AUTHOR), De Herdt, D.¹ (AUTHOR), Bhaskar, P.³ (AUTHOR), Zhu, Y.³ (AUTHOR), Looser, Z. J.⁷ (AUTHOR), Loncke, J.⁴ (AUTHOR), Gsell, W.⁸ (AUTHOR), Plaas, M.⁹ (AUTHOR), Agostinis, P.¹⁰ (AUTHOR), Swinnen, J. V.¹¹ (AUTHOR), Van Den Bosch, L.^5,6 (AUTHOR)

Publikováno v: Acta Neuropathologica Communications. 8/28/2024, Vol. 12 Issue 1, p1-23. 23p.