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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Autor: Surendran P; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Drenos F; Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.; Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, Rayne Building University College London, London, UK., Young R; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Warren H; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Cook JP; Department of Health Sciences, University of Leicester, Leicester, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Manning AK; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sim X; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore., Barnes DR; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Witkowska K; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Staley JR; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Tragante V; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., Tukiainen T; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Yaghootkar H; Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Masca N; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK., Freitag DF; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Giannakopoulou O; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Tinker A; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Harakalova M; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Liu C; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA., Kraja AT; Division of Statistical Genomics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA., Fallgaard Nielsen S; Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark., Rasheed A; Centre for Non-Communicable Diseases, Karachi, Pakistan., Samuel M; Centre for Non-Communicable Diseases, Karachi, Pakistan., Zhao W; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA., Jackson AU; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA., Southam L; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Marten J; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Huyghe JR; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Stančáková A; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Fava C; University of Lund, Department of Clinical Sciences, Malmö, Sweden.; University of Verona, Department of Medicine, Verona, Italy., Ohlsson T; University of Lund, Department of Clinical Sciences, Malmö, Sweden., Matchan A; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK., Stirrups KE; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Bork-Jensen J; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gjesing AP; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kontto J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Perola M; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Institute of Molecular Medicine FIMM, University of Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Shaw-Hawkins S; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK., Havulinna AS; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Zhang H; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA., Donnelly LA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rayner NW; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK., Neville MJ; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK., Robertson NR; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Yiorkas AM; Section of Investigative Medicine, Imperial College London, London, UK.; Department of Life Sciences, Brunel University London, London, UK., Herzig KH; Institute of Biomedicine, Biocenter Oulu, University of Oulu, Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland., Kajantie E; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.; Department of Obstetrics and Gynaecology, Oulu University Hospital and University of Oulu, Oulu, Finland., Zhang W; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK., Willems SM; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Lannfelt L; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Malerba G; Section of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Soranzo N; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Trabetti E; Section of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Verweij N; University Medical Center Groningen, University of Groningen, Department of Cardiology, The Netherlands.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Moayyeri A; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Farr Institute of Health Informatics Research, Institute of Health Informatics, University College London, London, UK., Vergnaud AC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK., Poveda A; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Bilbao, Spain., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Caslake M; University of Glasgow, Glasgow, UK., de Craen AJ; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Mr. De Craen suddenly passed away January 2016., Trompet S; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Luan J; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Scott RA; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Liewald DC; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Marioni R; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, UK., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Hallmans G; Department of Biobank Research, Umeå University, Umeå, Sweden., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Biobank Research, Umeå University, Umeå, Sweden., Huffman JE; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA., Hassinen M; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Burgess S; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Vasan RS; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.; Section of Cardiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA.; Sections of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, USA., Felix JF; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Uria-Nickelsen M; Development Management and Planning, Pfizer Worldwide Research and Development., Malarstig A; Pfizer Worldwide Research and Development, Stockholm, Sweden., Reily DF; Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA., Hoek M; Merck Research Laboratories, Cardiometabolic Disease, Kenilworth, New Jersey, USA., Vogt T; Merck Research Laboratories, Cardiometabolic Disease, Kenilworth, New Jersey, USA.; CHDI Management/CHDI Foundation, Princeton, New Jersey, USA., Lin H; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA., Lieb W; Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany., Traylor M; Neurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Markus HF; Neurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Highland HM; University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, North Carolina, USA., Justice AE; University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, North Carolina, USA., Marouli E; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Lindström J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.; Research Unit, Kuopio University Hospital, Kuopio, Finland., Komulainen P; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Polasek O; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; Faculty of Medicine, University of Split, Croatia., Rudan I; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Rolandsson O; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, UK., Jousilahti P; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Männistö S; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, UK., Langenberg C; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Wareham NJ; Medical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK., Brown MJ; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Connell JM; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; The Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Ford I; University of Glasgow, Glasgow, UK., Packard CJ; University of Glasgow, Glasgow, UK., Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA., Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, Tartu, Estonia., de Boer RA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van der Meer P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands., Gambaro G; Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus - Gemelli University Hospital, Catholic University, Rome, Italy., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA., Lind L; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., de Bakker PI; Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Numans ME; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Christensen C; Medical Department, Lillebaelt Hospital, Vejle, Denmark., Petersen ER; Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Korpi-Hyövälti E; South Ostrobothnia Central Hospital, Seinäjoki, Finland., Oksa H; Tampere University Hospital, Tampere, Finland., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; Imperial College Healthcare NHS Trust, London, UK., Kooner JS; Department of Cardiology, Ealing Hospital, Middlesex, UK.; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Blakemore AI; Section of Investigative Medicine, Imperial College London, London, UK.; Department of Life Sciences, Brunel University London, London, UK., Franks S; Institute of Reproductive and Developmental Biology, Imperial College London, London, UK., Jarvelin MR; Department of Epidemiology and Biostatistics, Medical Research Council Public Health England Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, UK.; Centre for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Husemoen LL; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark., Linneberg A; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.; Department of Clinical Experimental Research, Glostrup University Hospital, Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Skaaby T; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark., Thuesen B; Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark., Karpe F; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK., Tuomilehto J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Dasman Diabetes Institute, Dasman, Kuwait.; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.; King Abdulaziz University, Jeddah, Saudi Arabia., Doney AS; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Morris AD; School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh, UK., Palmer CN; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Holmen OL; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.; St. Olav Hospital, Trondheim University Hospital, Trondheim, Norway., Hveem K; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.; Department of Medicine, Levanger Hospital, Nord- Trøndelag Health Trust, Levanger, Norway., Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Tuomi T; Folkhälsan Research Centre, Helsinki, Finland; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.; Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Palotie A; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland.; Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA., Ripatti S; Institute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Finland.; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK., Salomaa V; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Alam DS; ICDDR, B; Mohakhali, Dhaka, Bangladesh., Shafi Majumder AA; National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh., Di Angelantonio E; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Chowdhury R; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., McCarthy MI; Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital Trusts, Oxford, UK.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Poulter N; International Centre for Circulatory Health, Imperial College London, UK., Stanton AV; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Sever P; International Centre for Circulatory Health, Imperial College London, UK., Amouyel P; University of Lille, UMR1167, Risk Factors and Molecular Determinants of aging-related diseases, Lille, France.; Inserm, Lille, France.; Centre Hospitalier Universitaire Lille, Public Health, Lille, France.; Institut Pasteur de Lille, Lille, France., Arveiler D; Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Strasbourg, France., Blankenberg S; Department of General and Interventional Cardiology, University Heart Center Hamburg, Germany.; University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ferrières J; Department of Epidemiology, UMR 1027- INSERM, Toulouse University-CHU Toulouse, Toulouse, France., Kee F; Director, UKCRC Centre of Excellence for Public Health, Queens University, Belfast, Northern Ireland., Kuulasmaa K; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany., Veronesi G; Research Center in Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy., Virtamo J; Department of Health, National Institute for Health and Welfare, Helsinki, Finland., Deloukas P; Heart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Elliott P; Department of Epidemiology and Biostatistics, Medical Research Council Public Health England Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, UK., Zeggini E; Wellcome Trust Sanger Institute, Genome Campus, Hinxton, UK., Kathiresan S; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA., Melander O; University of Lund, Department of Clinical Sciences, Malmö, Sweden., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Porteous D; Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Hayward C; Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Scotland G; A Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee, Edinburgh and Glasgow, UK., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen O; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Boehnke M; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Stringham HM; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA., Frossard P; Centre for Non-Communicable Diseases, Karachi, Pakistan., Newton-Cheh C; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, UK., Nordestgaard BG; Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK., Mahajan A; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Morris AP; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Tomaszewski M; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK.; Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Disease, Leicester, UK., Saleheen D; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Centre for Non-Communicable Diseases, Karachi, Pakistan.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Asselbergs FW; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.; Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London, UK., Lindgren CM; The Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, USA.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Danesh J; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK., Wain LV; Department of Health Sciences, University of Leicester, Leicester, UK., Butterworth AS; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; The National Institute for Health Research Blood and Transplant Research., Howson JM; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.

Publikováno v: Nature genetics [Nat Genet] 2016 Oct; Vol. 48 (10), pp. 1151-1161. Date of Electronic Publication: 2016 Sep 12.