Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Reilly G Fankhauser"'
Autor:
Alaksh Choudhury, Jacob A Fenster, Reilly G Fankhauser, Joel L Kaar, Olivier Tenaillon, Ryan T Gill
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 3, Pp 1-22 (2020)
Abstract Deep mutational scanning can provide significant insights into the function of essential genes in bacteria. Here, we developed a high‐throughput method for mutating essential genes of Escherichia coli in their native genetic context. We us
Externí odkaz:
https://doaj.org/article/5f2e06ad113d433aa65e1e649e871ef6
Publikováno v:
Molecules, Vol 25, Iss 9, p 2265 (2020)
Drug resistance is a major healthcare challenge, resulting in a continuous need to develop new inhibitors. The development of these inhibitors requires an understanding of the mechanisms of resistance for a critical mass of occurrences. Recent genome
Externí odkaz:
https://doaj.org/article/0ebe8c9a4b054fc598a8802d49c84548
Autor:
Nicholas A. DePatie, Karla Pivik, Richard A. Sturm, Darren J. Smit, Allison M. Fuiten, Mary A. Wood, Trevor Enright, Reilly G. Fankhauser, Elizabeth G. Berry, Rajan P. Kulkarni, Mitchell S. Stark
Publikováno v:
Pigment Cell & Melanoma Research. 34:1123-1130
Here, we present a rare case of a patient who developed multiple primary melanomas within the boundaries of two nevi depigmentosa. The melanomas were excised, and as a preventive measure, the remainder of the nevi depigmentosa were removed. We perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b92d3bc2bb0cfb1d44daa837cb51c60
https://doi.org/10.1111/pcmr.12979
https://doi.org/10.1111/pcmr.12979
Autor:
Ryan T. Gill, Alaksh Choudhury, Reilly G. Fankhauser, Emily F. Freed, Eun Joong Oh, Andrew B. Morgenthaler, Marcelo C. Bassalo, Shelley D. Copley, Joel L. Kaar
Publikováno v:
Choudhury, A, Fankhauser, R G, Freed, E F, Oh, E J, Morgenthaler, A B, Bassalo, M C, Copley, S D, Kaar, J L & Gill, R T 2020, ' Determinants for efficient editing with cas9-mediated recombineering in Escherichia coli ', ACS Synthetic Biology, vol. 9, no. 5, pp. 1083-1099 . https://doi.org/10.1021/acssynbio.9b00440
In E. coli, editing efficiency with Cas9-mediated recombineering varies across targets due to differences in the level of Cas9:gRNA-mediated DNA double-strand break (DSB)-induced cell death. We found that editing efficiency with the same gRNA and rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e44b6721d8770500533bdde4ff71c0
https://doi.org/10.1021/acssynbio.9b00440
https://doi.org/10.1021/acssynbio.9b00440
Autor:
Rajan P. Kulkarni, Nicholas A. DePatie, Reilly G. Fankhauser, Rachel Berryman, Olivia M. Lucero
Publikováno v:
Engineering Technologies and Clinical Translation ISBN: 9780323909495
Immunotherapies are a central treatment modality in cancer therapeutics, yet much is still to be determined about their complex mechanisms of action that will allow us to stratify patients based on their likelihood of benefitting from this treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e16df2a303c60e8f26ea6f79df379b4
https://doi.org/10.1016/b978-0-323-90949-5.00007-3
https://doi.org/10.1016/b978-0-323-90949-5.00007-3
Autor:
Alaksh, Choudhury, Reilly G, Fankhauser, Emily F, Freed, Eun Joong, Oh, Andrew B, Morgenthaler, Marcelo C, Bassalo, Shelley D, Copley, Joel L, Kaar, Ryan T, Gill
Publikováno v:
ACS synthetic biology. 9(5)
In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f126fbcb2cb336770195f1de9bf8c54
https://pubmed.ncbi.nlm.nih.gov/32298586
https://pubmed.ncbi.nlm.nih.gov/32298586
Autor:
Olivier Tenaillon, Jacob A Fenster, Alaksh Choudhury, Joel L. Kaar, Ryan T. Gill, Reilly G. Fankhauser
Publikováno v:
Molecular Systems Biology
Choudhury, A, Fenster, J A, Fankhauser, R G, Kaar, J L, Tenaillon, O & Gill, R T 2020, ' CRISPR/Cas9 recombineering-mediated deep mutational scanning of essential genes in Escherichia coli ', Molecular Systems Biology, vol. 16, no. 3, e9265 . https://doi.org/10.15252/msb.20199265
Molecular Systems Biology, Vol 16, Iss 3, Pp n/a-n/a (2020)
Choudhury, A, Fenster, J A, Fankhauser, R G, Kaar, J L, Tenaillon, O & Gill, R T 2020, ' CRISPR/Cas9 recombineering-mediated deep mutational scanning of essential genes in Escherichia coli ', Molecular Systems Biology, vol. 16, no. 3, e9265 . https://doi.org/10.15252/msb.20199265
Molecular Systems Biology, Vol 16, Iss 3, Pp n/a-n/a (2020)
Deep mutational scanning can provide significant insights into the function of essential genes in bacteria. Here, we developed a high‐throughput method for mutating essential genes of Escherichia coli in their native genetic context. We used Cas9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93facc51d4857dd4dae480fc30344dbc
http://europepmc.org/articles/PMC7073797
http://europepmc.org/articles/PMC7073797
Autor:
Ryan T. Gill, Eun Joong Oh, Gur Pines, Reilly G. Fankhauser, Carrie Eckert, Alaksh Choudhury, Marcelo C. Bassalo, Andrew D. Garst
Publikováno v:
ACS Synthetic Biology. 7:2824-2832
Sequence to activity mapping technologies are rapidly developing, enabling the generation and isolation of mutations conferring novel phenotypes. Here we used the CRISPR EnAbled Trackable genome Engineering (CREATE) technology to investigate the inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ff26622fa12b92df46616859355bb4
https://doi.org/10.1021/acssynbio.8b00219
https://doi.org/10.1021/acssynbio.8b00219
Publikováno v:
Molecules
Molecules, Vol 25, Iss 2265, p 2265 (2020)
Molecules, Vol 25, Iss 2265, p 2265 (2020)
Drug resistance is a major healthcare challenge, resulting in a continuous need to develop new inhibitors. The development of these inhibitors requires an understanding of the mechanisms of resistance for a critical mass of occurrences. Recent genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51874c2713e5fd792f9f679520d57161
https://doi.org/10.3390/molecules25092265
https://doi.org/10.3390/molecules25092265