Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Reiko Yamagishi"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Ripasudil–brimonidine fixed-dose combination (K-232) simultaneously targets three different intraocular pressure (IOP) lowering mechanisms, increasing trabecular meshwork outflow and uveoscleral outflow, and reducing aqueous humor producti
Externí odkaz:
https://doaj.org/article/dd29460ebfc54370baf6fc3457027aee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract This study investigated the effects of omidenepag (OMD), a novel selective EP2 receptor agonist, on human trabecular meshwork (HTM) cells, monkey Schlemm’s canal endothelial (SCE) cells, and porcine ciliary muscle (CM) to clarify the mecha
Externí odkaz:
https://doaj.org/article/dccdf48355c74765b1d9b965b6374adf
Autor:
Nozomi Igarashi, Megumi Honjo, Reiko Yamagishi, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Toshikatsu Kaburaki, Makoto Aihara
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-19 (2021)
Abstract Background Elevated transforming growth factor (TGF)-β2 in aqueous humor (AH) has been suggested to contribute to trabecular meshwork (TM) fibrosis and intraocular pressure (IOP) regulation in primary open-angle glaucoma (POAG), but TGF-β2
Externí odkaz:
https://doaj.org/article/f3b98da63d58464db84a7f1377e8342a
Autor:
Takatoshi Uchida, Shota Shimizu, Reiko Yamagishi, Suzumi M. Tokuoka, Yoshihiro Kita, Megumi Honjo, Makoto Aihara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The trabecular meshwork (TM) constitutes the main pathway for aqueous humor drainage and is exposed to complex intraocular pressure fluctuations. The mechanism of homeostasis in which TM senses changes in intraocular pressure and leads to no
Externí odkaz:
https://doaj.org/article/3a790bb7932047738f10802992a9fe8f
Autor:
Megumi Honjo, Reiko Yamagishi, Nozomi Igarashi, Chui Yong Ku, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Makoto Aihara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract To evaluate the effect of postoperative corticosteroids on surgical outcome and autotaxin (ATX) levels after microhook ab interno trabeculotomy combined with cataract surgery (μLOT-CS), prospective, consecutive non-randomized case series co
Externí odkaz:
https://doaj.org/article/0ac581e447db48879d9840707b12df94
Autor:
Mengxuan Liu, Megumi Honjo, Reiko Yamagishi, Nozomi Igarashi, Natsuko Nakamura, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Makoto Aihara
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1231 (2022)
This study examines the potential role of transforming growth factor-beta 3 (TGF-β3) on the fibrotic response of cultured human trabecular meshwork (HTM) cells. The relationships and trans-signaling interactions between TGF-β3 and autotaxin (ATX) i
Externí odkaz:
https://doaj.org/article/f97501647b624c01a7485a96869c63e8
Autor:
Yang Liu, Reiko Yamagishi, Megumi Honjo, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Makoto Aihara
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9181 (2022)
Autotaxin (ATX) is an enzymatic with lysophospholipase D (lysoPLD) activity. We investigated the role of ATX in high glucose (HG)-induced human retinal pigment epithelial (ARPE-19) cells to explore the pathogenesis of diabetic retinopathy (DR). We pe
Externí odkaz:
https://doaj.org/article/6dc21dff57a046aab2d70cb0d9b8bda8
Autor:
Takatoshi Uchida, Shota Shimizu, Reiko Yamagishi, Suzumi M. Tokuoka, Yoshihiro Kita, Rei Sakata, Megumi Honjo, Makoto Aihara
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of the triggers to regulate aqueous outflow in trabecular meshwork, but i
Externí odkaz:
https://doaj.org/article/22ef1f2aa6244fa88337b567288ff18d
Autor:
Takashi Fujishiro, Megumi Honjo, Hiroshi Kawasaki, Ryo Asaoka, Reiko Yamagishi, Makoto Aihara
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1339 (2020)
We investigated structural changes and astrocyte responses of the lateral geniculate nucleus (LGN) in a ferret model of ocular hypertension (OH). In 10 ferrets, OH was induced via the injection of cultured conjunctival cells into the anterior chamber
Externí odkaz:
https://doaj.org/article/2c6db1c75ace4129b515256ed67eb32f
Autor:
Xue Tan, Katsuhito Fujiu, Ichiro Manabe, Junko Nishida, Reiko Yamagishi, Yuya Terashima, Kouji Matsushima, Toshikatsu Kaburaki, Ryozo Nagai, Yasuo Yanagi
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160985 (2016)
To determine the involvement of sympathetic activity in choroidal neovascularization (CNV) using laser-induced CNV in a mouse model.We investigated changes in the proportions of intraocular lymphocytes, granulocytes, and three macrophage subtypes (Ly
Externí odkaz:
https://doaj.org/article/964bc0b0541f416da0b9323f3b80e941