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pro vyhledávání: '"Reiko Watanabe-Uruma"'
Autor:
Reiko Watanabe-Uruma, Yuichi Takiguchi, Masato Shingyoji, Koichiro Tatsumi, Yoshiko Asaka-Amano, Hiroshi Matsubara, Nobuhiro Tanabe, Takayuki Kuriyama, Katsushi Kurosu, Yasunori Kasahara
Publikováno v:
Cancer science. 95(6)
Irinotecan is an active cytotoxic agent for various cancers, and is converted to SN-38, its most active metabolite, by carboxylesterase converting enzyme (CCE) in vivo. Although the primary metabolic site is in the liver, ex vivo studies have proven