Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Reiko Ueoka"'
Autor:
Olha Schneider, Martin Zehl, Reiko Ueoka, Christian Rückert, Tobias Buche, Yi Jiang, Qin-Yuan Li, Jörn Piel, Sergey B. Zotchev
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT The antibiotic desertomycin A and its previously undescribed inactive N-succinylated analogue, desertomycin X, were isolated from Streptomyces sp. strain YIM 121038. Genome sequencing and analysis readily identified the desertomycin biosynth
Externí odkaz:
https://doaj.org/article/4693ef7852a54d4aa98c22d9f4734ea3
Autor:
Eric J. N. Helfrich, Reiko Ueoka, Marc G. Chevrette, Franziska Hemmerling, Xiaowen Lu, Stefan Leopold-Messer, Hannah A. Minas, Adrien Y. Burch, Steven E. Lindow, Jörn Piel, Marnix H. Medema
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of
Externí odkaz:
https://doaj.org/article/364e7f915c97493a91491df3c9ed6014
Autor:
Kei Kudo, Takuya Hashimoto, Junko Hashimoto, Ikuko Kozone, Noritaka Kagaya, Reiko Ueoka, Takehiro Nishimura, Mamoru Komatsu, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Several different genetic strategies have been reported for the modification of polyketide synthases but the highly repetitive modular structure makes this difficult. Here the authors report on an adapted Cas9 reaction and Gibson assembly to edit a t
Externí odkaz:
https://doaj.org/article/6d001e0fbfd74c5b9143e6e06438d202
Autor:
Sanya Sureram, Irene Arduino, Reiko Ueoka, Massimo Rittà, Rachele Francese, Rattanaporn Srivibool, Dhanushka Darshana, Jörn Piel, Somsak Ruchirawat, Luisa Muratori, David Lembo, Prasat Kittakoop, Manuela Donalisio
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 947 (2022)
Herpesviruses are highly prevalent in the human population, and frequent reactivations occur throughout life. Despite antiviral drugs against herpetic infections, the increasing appearance of drug-resistant viral strains and their adverse effects pro
Externí odkaz:
https://doaj.org/article/f843ee35ddd64829a957adc455b4fbac
Autor:
Pakjira Nanudorn, Sirinthra Thiengmag, Friederike Biermann, Pelin Erkoc, Sabrina D. Dirnberger, Thao N. Phan, Robert Fürst, Reiko Ueoka, Eric J. N. Helfrich
Publikováno v:
Angewandte Chemie. 134
Biomacromolecules are known to feature complex three-dimensional shapes that are essential for their function. Among natural products, ambiguous molecular shapes are a rare phenomenon. The hexapeptide tryptorubin A can adopt one of two unusual atropi
Autor:
Takuya Hashimoto, Haruo Ikeda, Noritaka Kagaya, Kei Kudo, Reiko Ueoka, Hikaru Suenaga, Kazuo Shin-ya, Ikuko Kozone, Junko Hashimoto
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 85:890-894
A novel methymycin analog, 12-ketomethymycin N-oxide, was produced by the heterologous expression of the pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900 together with 12-ketomethymycin, which was only isolated by the biotra
Autor:
Franziska Hemmerling, Roy A. Meoded, Amy E. Fraley, Hannah A. Minas, Cora L. Dieterich, Michael Rust, Reiko Ueoka, Katja Jensen, Eric J. N. Helfrich, Cedric Bergande, Maurice Biedermann, Nancy Magnus, Birgit Piechulla, Jörn Piel
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie. International Edition, 61 (11)
Angewandte Chemie. International Edition, 61 (11)
Bacterial multimodular polyketide synthases (PKSs) are large enzymatic assembly lines that synthesize many bioactive natural products of therapeutic relevance. While PKS catalysis is mostly based on fatty acid biosynthetic principles, polyketides can
Autor:
Cora L. Dieterich, Silke I. Probst, Reiko Ueoka, Ioana Sandu, Daniel Schäfle, Michael Dal Molin, Hannah A. Minas, Rodrigo Costa, Annette Oxenius, Peter Sander, Jörn Piel
Publikováno v:
Angewandte Chemie International Edition. 61
Genome mining and bioactivity studies suggested the sponge-derived bacterium Aquimarina sp. Aq135 as a producer of new antibiotics. Activity-guided isolation identified antibacterial peptides, named aquimarins, featuring a new scaffold with an unusua
Autor:
Sanya, Sureram, Irene, Arduino, Reiko, Ueoka, Massimo, Rittà, Rachele, Francese, Rattanaporn, Srivibool, Dhanushka, Darshana, Jörn, Piel, Somsak, Ruchirawat, Luisa, Muratori, David, Lembo, Prasat, Kittakoop, Manuela, Donalisio
Publikováno v:
International Journal of Molecular Sciences
Herpesviruses are highly prevalent in the human population, and frequent reactivations occur throughout life. Despite antiviral drugs against herpetic infections, the increasing appearance of drug-resistant viral strains and their adverse effects pro
Autor:
Kazuo Shin-ya, Junko Hashimoto, Mamoru Komatsu, Takehiro Nishimura, Noritaka Kagaya, Ikuko Kozone, Haruo Ikeda, Hikaru Suenaga, Kei Kudo, Reiko Ueoka, Takuya Hashimoto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
One major bottleneck in natural product drug development is derivatization, which is pivotal for fine tuning lead compounds. A promising solution is modifying the biosynthetic machineries of middle molecules such as macrolides. Although intense studi