Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Reiko Maki Fitzsimonds"'
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
The average age when physician-scientists begin their career has been rising. Here, we focused on one contributor to this change: the increasingly common decision by candidates to postpone applying to MD-PhD programs until after college. This creates
Externí odkaz:
https://doaj.org/article/7e0b44e01f324d91926e9b4aebdf4582
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 1, Pp 217-227 (2006)
Rett syndrome is an X-linked neurodevelopmental disorder caused by mutations in the gene encoding the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2). Here we demonstrate that the Mecp2-null mouse model of Rett syndrome shows an age-de
Externí odkaz:
https://doaj.org/article/98ac38e7c7374f82aec679d62c1d155b
Publikováno v:
Physiology. 21:346-351
The cellular mechanisms contributing to long-term potentiation and activity-induced formation of glutamatergic synapses have been intensely debated. Recent studies have sparked renewed interest in the role of presynaptic components in these processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2027edc8f6b25d4467d86d883c1f2902
https://doi.org/10.1152/physiol.00013.2006
https://doi.org/10.1152/physiol.00013.2006
Autor:
Sarah L. King, Inés Ibañez-Tallon, Reiko Maki Fitzsimonds, Constantine Pavlides, Barbara J. Caldarone, Nathaniel Heintz, Marina R. Picciotto, Cheng Xiao, Henry A. Lester, Julie M. Miwa, Tanya R. Stevens
Publikováno v:
Neuron. 51(5):587-600
Nicotinic acetylcholine receptors (nAChRs) affect a wide array of biological processes, including learning and memory, attention, and addiction. lynx1, the founding member of a family of mammalian prototoxins, modulates nAChR function in vitro by alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea9098850a7a4bd7555455ffc1c2567
Publikováno v:
Journal of Neuroscience Methods. 152:32-39
The use of fluorescent probes such as FM 1-43 or synapto-pHluorin to study the dynamic aspects of synaptic function has dramatically increased in recent years. The analysis of such experiments is both labor intensive and subject to potentially signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa9a85f9da1070dc75217acf3d5805b
https://doi.org/10.1016/j.jneumeth.2005.08.008
https://doi.org/10.1016/j.jneumeth.2005.08.008
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 1, Pp 217-227 (2006)
Rett syndrome is an X-linked neurodevelopmental disorder caused by mutations in the gene encoding the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2). Here we demonstrate that the Mecp2-null mouse model of Rett syndrome shows an age-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64611180ebd56a305515be7108c53ee
https://doi.org/10.1016/j.nbd.2005.07.005
https://doi.org/10.1016/j.nbd.2005.07.005
Autor:
Barbara J. Caldarone, Luanne L. Peters, Yukiko Asaka, Reiko Maki Fitzsimonds, Nii A. Addy, Diana M. Gilligan, Rebecca L. Rabenstein, Marina R. Picciotto, Lore Gruenbaum
Publikováno v:
The Journal of Neuroscience. 25:2138-2145
The adducin family of proteins interacts with the actin cytoskeleton and the plasma membrane in a calcium- and cAMP-dependent manner. Thus, adducins may be involved in changes in cytoskeletal organization resulting from synaptic stimulation. β-Adduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d6a7bcd8120bc1d65fd480532cab71
https://doi.org/10.1523/jneurosci.3530-04.2005
https://doi.org/10.1523/jneurosci.3530-04.2005
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking
Autor:
Reiko Maki Fitzsimonds, Gilbert Di Paolo, Keith E. Gipson, Pietro De Camilli, Masanori Obayashi, Timothy A. Ryan, Richard A. Flavell, Markus R. Wenk, Howard S. Moskowitz, Sergey V. Voronov
Publikováno v:
Nature. 431:415-422
Phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) has an important function in cell regulation both as a precursor of second messenger molecules and by means of its direct interactions with cytosolic and membrane proteins. Biochemical studies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efe090cd9b2742f9e6863da7519a80c
https://doi.org/10.1038/nature02896
https://doi.org/10.1038/nature02896
Publikováno v:
Neuron. 40(5):945-957
Whether contact of an axon with a dendrite is a necessary inductive signal for the assembly of functional presynaptic machinery is controversial. Combining FM1-43 imaging with retrospective immunocytochemistry, we observe many functional synaptic ves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c6da63988725755681c701956f1883
Publikováno v:
The Journal of Neuroscience. 23:10093-10099
Regulation of intracellular calcium influences neuronal excitability, synaptic plasticity, gene expression, and neurotoxicity. In this study, we investigated the role of calcium in mechanisms underlying nicotine-mediated neuroprotection from glutamat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff522eab9c7b27a4995cf16f2a70c68
https://doi.org/10.1523/jneurosci.23-31-10093.2003
https://doi.org/10.1523/jneurosci.23-31-10093.2003