Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Reiko Ishitsuka"'
Autor:
Hema Balakrishna Bhat, Takuma Kishimoto, Mitsuhiro Abe, Asami Makino, Takehiko Inaba, Motohide Murate, Naoshi Dohmae, Atsushi Kurahashi, Kozo Nishibori, Fumihiro Fujimori, Peter Greimel, Reiko Ishitsuka, Toshihide Kobayashi
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2933-2943 (2013)
A mixture of sphingomyelin (SM) and cholesterol (Chol) exhibits a characteristic lipid raft domain of the cell membranes that provides a platform to which various signal molecules as well as virus and bacterial proteins are recruited. Several protein
Externí odkaz:
https://doaj.org/article/a052151917524820855157df559a10a8
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 2084-2094 (2011)
An automated fluorescence microscopy assay using a nontoxic cholesterol binding protein, θ toxin domain 4, (D4), was developed in order to identify chemical compounds modifying intracellular cholesterol metabolism and distribution. Using this method
Externí odkaz:
https://doaj.org/article/7d1a3502d55840a4a7a319fd2038374f
Autor:
Takuma Kishimoto, Toshihide Kobayashi, Nario Tomishige, Hubert Schaller, Kazumitsu Ueda, Yves Mély, Motohide Murate, Reiko Ishitsuka
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (5), pp.6185-6197. ⟨10.1096/fj.201900065RR⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (5), pp.6185-6197. ⟨10.1096/fj.201900065RR⟩
During adhesion, cells develop filopodia to facilitate the attachment to the extracellular matrix. The small guanosine triphosphate (GTP)-binding protein, Cdc42, plays a central role in the formation of filopodia. It has been reported that Cdc42 acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbafbd3660a88ca61d808e253306896e
https://doi.org/10.1096/fj.201900065rr
https://doi.org/10.1096/fj.201900065rr
Autor:
Kozo Nishibori, Rinshi S. Kasai, Shota Sakai, Gregor Anderluh, Tetsuyuki Kobayashi, Shuku Kubo, Chan-Gi Pack, Yukiko Shimada, Peter Greimel, Yasushi Sako, Motohide Murate, Mitsuhiro Abe, Takehiko Inaba, Takanori Kigawa, Fumihiro Fujimori, Françoise Hullin-Matsuda, Naoya Tochio, Makoto Yamashita, Takuma Kishimoto, Naoshi Dohmae, Yoko Aida, Hideyuki Miyatake, Kyoji Hagiwara, Asami Makino, Robert G. Parton, Yutaka Sasaki, Toshihide Kobayashi, Reiko Ishitsuka, Atsushi Kurahashi, Akihiro Kusumi, Nicole L. Schieber, Hideko Tanaka
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2017, 31 (4), pp.1301-1322. ⟨10.1096/fj.201500075R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2017, 31 (4), pp.1301-1322. ⟨10.1096/fj.201500075R⟩
International audience; We identified a novel, nontoxic mushroom protein that specifically binds to a complex of sphingomyelin (SM), a major sphingolipid in mammalian cells, and cholesterol (Chol). The purified protein, termed nakanori, labeled cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f295fffc406225933c027ebe273c4f
https://doi.org/10.1096/fj.201500075r
https://doi.org/10.1096/fj.201500075r
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861:812-829
Although sphingomyelin and cholesterol are major lipids of mammalian cells, the detailed distribution of these lipids in cellular membranes remains still obscure. However, the recent development of protein probes that specifically bind sphingomyelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e411b4a721924e67f01025f3136412c
https://doi.org/10.1016/j.bbalip.2016.03.013
https://doi.org/10.1016/j.bbalip.2016.03.013
Autor:
Motohide Murate, Takehiko Inaba, Takuma Kishimoto, Reiko Ishitsuka, Mitsuhiro Abe, Asami Makino, Shota Sakai, Yasuo Ikeda, Toshihide Kobayashi, Takuya Tajima, Shinji Takeoka, Nario Tomishige
Publikováno v:
Proceedings of the National Academy of Sciences. 113:7834-7839
Lipid membrane curvature plays important roles in various physiological phenomena. Curvature-regulated dynamic membrane remodeling is achieved by the interaction between lipids and proteins. So far, several membrane sensing/sculpting proteins, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8713fefe1f8430087e6b6c8e9574349b
https://doi.org/10.1073/pnas.1603513113
https://doi.org/10.1073/pnas.1603513113
Publikováno v:
Biochimie. 107:43-50
This mini-review presents recent advances in the regulation of the membrane transbilayer movement (or flip-flop) of diacylglycerol (DAG), a key intermediate in lipid metabolism and a second messenger in lipid-mediated signaling. Despite progresses in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116d81412ff6b44816d937d37f9fd9a1
https://doi.org/10.1016/j.biochi.2014.09.014
https://doi.org/10.1016/j.biochi.2014.09.014
Autor:
Hiroyuki Osada, Michel Lagarde, Shota Sakai, Peter Greimel, Nario Tomishige, Françoise Hullin-Matsuda, Hubert Vidal, Anthony H. Futerman, Kumiko Ishii, Elad L. Laviad, Reiko Ishitsuka, Mitsuhiro Abe, Kentaro Hanada, Asami Makino, Tamio Saito, Toshihide Kobayashi
Publikováno v:
Journal of Biological Chemistry. 287:24397-24411
To identify novel inhibitors of sphingomyelin (SM) metabolism, a new and selective high throughput microscopy-based screening based on the toxicity of the SM-specific toxin, lysenin, was developed. Out of a library of 2011 natural compounds, the limo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edc5b8b7d4c517237f0f12f64d71ce4
https://doi.org/10.1074/jbc.m112.344432
https://doi.org/10.1074/jbc.m112.344432
Publikováno v:
Chemical Physics Letters. 522:96-102
We have investigated flip-flop motions of diacylglycerol and ceramide in phospholipid bilayers using coarse-grained molecular dynamics simulations. In the simulations, flip-flop motions of diacylglycerol and ceramide in the DAPC membrane are slower t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::690397689d4b7611a5381da8a3f563f5
https://doi.org/10.1016/j.cplett.2011.11.057
https://doi.org/10.1016/j.cplett.2011.11.057
Autor:
Atsushi Kurahashi, Kozo Nishibori, Fumihiro Fujimori, Reiko Ishitsuka, Naoto Juni, Akiko Yamaji-Hasegawa, Hema Balakrishna Bhat, Kohjiro Nagao, Takuma Kishimoto, Asami Makino, Kisaburo Nagamune, Toshihide Kobayashi, Mitsuhiro Abe, Peter Greimel, Akinori Yamano, Motohide Murate, Masato Umeda, Ayako Kohyama-Koganeya, Takehiko Inaba, Yoshio Hirabayashi, Michiru Tahara
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(9)
Ceramide phosphoethanolamine (CPE), a sphingomyelin analog, is a major sphingolipid in invertebrates and parasites, whereas only trace amounts are present in mammalian cells. In this study, mushroom-derived proteins of the aegerolysin family—pleuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae03ec0e253022ce5d1ce0abb10833b
https://pubmed.ncbi.nlm.nih.gov/26060215
https://pubmed.ncbi.nlm.nih.gov/26060215