Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Reiko Eyanagi"'
Autor:
Toshiaki Amamoto, Masumi Imoto, Shuso Takeda, Kazuhito Watanabe, Ikuo Yamamoto, Reiko Eyanagi, Hironori Aramaki, Rongrong Jiang, Akihisa Toda
Publikováno v:
Journal of Pharmaceutical Sciences. 100:1206-1211
15-Lipoxygenase (15-LOX) is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein, a major causal factor for atherosclerosis. Δ(9)-Tetrahydrocannabinol (Δ(9)-THC), a major component of marijuana, has suggested to
Autor:
Shigeru Ohta, Naoto Uramaru, Reiko Eyanagi, Hidenari Shigematsu, Shigeyuki Kitamura, Akihisa Toda
Publikováno v:
Journal of Medicinal Chemistry. 53:8727-8733
To develop novel nonallergenic pyrazolone analgesics, we synthesized a series of compounds in which position 1 of the pyrazolone ring was substituted in place of the original methyl group in order to block the formation of allergenic metabolites via
Autor:
Kazuya Yasuda, Shirashi Shibuya, Tsutomu Yokomastu, Reiko Eyanagi, Sadao Hikishima, Yukako Kuramoto, Akihisa Toda, Takashi Ochiai, Hiroshi Shimeno, Shinji Soeda, Akira Sakata
Publikováno v:
Current Drug Therapy. 3:218-225
Publikováno v:
Neuroscience Letters. 431:66-70
We investigated the mechanism underlying the anxiolytic actions of the neuropeptide nociceptin/orphanin FQ (N/OFQ) using the elevated plus-maze test and T-maze test. Microinfusions of N/OFQ (10 or 32pmol) into the central amygdala (ACE) increased the
Autor:
Tsutomu Yokomatsu, Reiko Eyanagi, Akihisa Toda, Shinji Soeda, Hiroshi Shimeno, Sadao Hikishima, Akira Sakata, Takashi Ochiai, Shiroshi Shibuya
Publikováno v:
Immunology. 122:54-64
Lipopolysaccharide (LPS) and inflammatory cytokines cause activation of sphingomyelinases (SMases) and subsequent hydrolysis of sphingomyelin (SM) to produce a lipid messenger ceramide. The design of SMase inhibitors may offer new therapies for the t
Autor:
Satoru Koyanagi, K. Shinomiya, Hiroshi Shimeno, Shinji Soeda, Reiko Eyanagi, A. Toda, Takashi Ochiai
Publikováno v:
Neuroscience. 141:101-108
Astrocytes are thought to be critical to neurons' surviving damage caused by ischemic stroke or other injury. Plasminogen activator inhibitor-1 is one of the active soluble factors released by astrocytes and regulates plasminogen activator-plasmin pr
Autor:
Yuji Ishii, Reiko Eyanagi, Hiroaki Kuroki, Masumi Imoto, Yukako Kuramoto, Akihisa Toda, Shinji Soeda, Hidemori Uchiyama, Hiroshi Shimeno
Publikováno v:
International immunopharmacology. 12(4)
Drug induced allergies are believed to be induced by conjugates consisting of biological macromolecules and active metabolites. The present study investigated whether guinea pig glutathione S-transferase (gpGST), a protein that binds with sulfanilami
Autor:
Hiroaki Kuroki, Satoko Nishimura, Hiroshi Shimeno, Akihisa Toda, Shigenori Watanabe, Masumi Imoto, Shinji Soeda, Hidemori Uchiyama, Reiko Eyanagi
Publikováno v:
Neuroscience letters. 469(2)
Abnormal behaviors and death associated with the use of oseltamivir (Tamiflu ® ) have emerged as a major issue in influenza patients taking the drug. Here, we investigated the mechanisms underlying the effects of oseltamivir on the behavior of mice
Autor:
Akihisa, Toda, Reiko, Eyanagi, Hiroshi, Saito, Shinji, Soeda, Hiroshi, Shimeno, Minehiro, Moriyama, Hidenari, Shigematsu
Publikováno v:
Research communications in molecular pathology and pharmacology.
Hepatic drug metabolism (flavin-containing monooxygenase (FMO), glutathione related enzymes, phase II conjugation reactions) and the hepatic contents of glutathione were investigated in normal rats, alloxan induced diabetic rats and streptozotocin (S
Autor:
Akihisa Toda, Takato Hiranita, Taku Yamaguchi, Hidemori Uchiyama, Reiko Eyanagi, Shigenori Watanabe
Publikováno v:
European journal of pharmacology. 590(1-3)
We investigated the mechanism underlying the anxiolytic actions of the neuropeptide nociceptin/orphanin FQ (N/OFQ) with an elevated plus-maze test. In mice, intracerebroventricular (i.c.v.) infusions of N/OFQ (0.1 and 0.32 nmol) led to an increase in