Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Reiko, Hanada"'
Autor:
Shaohong Lai, Hiroshi Shiraishi, Wulan Apridita Sebastian, Nobuyuki Shimizu, Ryohei Umeda, Mayo Ikeuchi, Kyoko Kiyota, Takashi Takeno, Shuya Miyazaki, Shinji Yano, Tatsuo Shimada, Akihiko Yoshimura, Reiko Hanada, Toshikatsu Hanada
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract SMG9 is an essential component of the nonsense-mediated mRNA decay (NMD) machinery, a quality control mechanism that selectively degrades aberrant transcripts. Mutations in SMG9 are associated with heart and brain malformation syndrome (HBMS
Externí odkaz:
https://doaj.org/article/69b86210ae654ce4bc27a66b71939425
Autor:
Masanori Inoue, Wulan Apridita Sebastian, Shota Sonoda, Hiroaki Miyahara, Nobuyuki Shimizu, Hiroshi Shiraishi, Miwako Maeda, Kumiko Yanagi, Tadashi Kaname, Reiko Hanada, Toshikatsu Hanada, Kenji Ihara
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background Biallelic pathogenic variants of LARS1 cause infantile liver failure syndrome type 1 (ILFS1), which is characterized by acute hepatic failure with steatosis in infants. LARS functions as a protein associated with mTORC1 and plays
Externí odkaz:
https://doaj.org/article/53ef72dfa87b4e6d82ec5d817e1bf0f2
Autor:
Tomoko Tokumaru, Magdeline E. Carrasco Apolinario, Nobuyuki Shimizu, Ryohei Umeda, Koichi Honda, Kenshiro Shikano, Hitoshi Teranishi, Takatoshi Hikida, Toshikatsu Hanada, Keisuke Ohta, Yulong Li, Kazunari Murakami, Reiko Hanada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Steatotic liver disease (SLD) is a burgeoning health problem predominantly associated with excessive alcohol consumption, which causes alcohol-related liver disease (ALD), and high caloric intake, which results in metabolic dysfunction-assoc
Externí odkaz:
https://doaj.org/article/09dc4a0c3612480e9dc4a4313df58550
Autor:
Masanori Inoue, Hiroaki Miyahara, Hiroshi Shiraishi, Nobuyuki Shimizu, Mika Tsumori, Kyoko Kiyota, Miwako Maeda, Ryohei Umeda, Tohru Ishitani, Reiko Hanada, Kenji Ihara, Toshikatsu Hanada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Leucyl-tRNA synthetase (LARS) is an enzyme that catalyses the ligation of leucine with leucine tRNA. LARS is also essential to sensitize the intracellular leucine concentration to the mammalian target of rapamycin complex 1 (mTORC1) activati
Externí odkaz:
https://doaj.org/article/735bf8722fc14b5aa74a3a1a7b470b4c
Autor:
Madoka Anan, Ryoko Higa, Kenshiro Shikano, Masahito Shide, Akinobu Soda, Magdeline E. Carrasco Apolinario, Kenji Mori, Toshitaka Shin, Mikiya Miyazato, Hiromitsu Mimata, Takatoshi Hikida, Toshikatsu Hanada, Kazuwa Nakao, Kenji Kangawa, Reiko Hanada
Publikováno v:
Heliyon, Vol 6, Iss 5, Pp e03947- (2020)
Neuromedin U (NMU) is a bioactive neuropeptide, highly distributed in the gastrointestinal tract and the central nervous system. NMU has various physiological functions related to feeding behavior, energy metabolism, stress responses, circadian rhyth
Externí odkaz:
https://doaj.org/article/4f0e8baf3e0044818528c244a4f8f1c4
Autor:
Hitoshi Teranishi, Reiko Hanada
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4238 (2021)
Obesity is now a public health concern. The leading cause of obesity is an energy imbalance between ingested and expended calories. The mechanisms of feeding behavior and energy metabolism are regulated by a complex of various kinds of molecules, inc
Externí odkaz:
https://doaj.org/article/cf6ea0665da54e449ff6c66f76695950
Autor:
Takatoshi Hikida, Hiroshi Shiraishi, Minoru Fujiki, Takashi Kobayashi, Hiroyuki Fujinami, Ikuko Morisaki, Josef M. Penninger, Toshikatsu Hanada, Reiko Hanada, Nobuyuki Shimizu, Yuji Arai
Publikováno v:
Biochemical and Biophysical Research Communications. 570:60-66
Cleavage factor polyribonucleotide kinase subunit 1 (CLP1), an RNA kinase, plays essential roles in protein complexes involved in the 3'-end formation and polyadenylation of mRNA and the tRNA splicing endonuclease complex, which is involved in precur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99652236678269d504d903de3d996012
https://doi.org/10.1016/j.bbrc.2021.07.036
https://doi.org/10.1016/j.bbrc.2021.07.036
Autor:
Yoshiaki, Yamaguchi, Iori, Murai, Momoko, Takeda, Shotaro, Doi, Takehito, Seta, Reiko, Hanada, Kenji, Kangawa, Hitoshi, Okamura, Takahito, Miyake, Masao, Doi
Publikováno v:
Biologicalpharmaceutical bulletin. 45(8)
The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals and is properly entrained by environmental light cycle. However, the molecular mechanism(s) determining the magnitude of phase shift by light is still not fully understood. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e890825891099f40c9b677760bc04527
https://pubmed.ncbi.nlm.nih.gov/35908898
https://pubmed.ncbi.nlm.nih.gov/35908898
Autor:
Wulan Apridita Sebastian, Hiroshi Shiraishi, Nobuyuki Shimizu, Ryohei Umeda, Shaohong Lai, Mayo Ikeuchi, Ikuko Morisaki, Shinji Yano, Akihiko Yoshimura, Reiko Hanada, Toshikatsu Hanada
Publikováno v:
Biochemical and biophysical research communications. 624
Autosomal recessive primary microcephaly (MCPH) is a rare congenital disorder characterized by a below average brain volume at birth and is associated with neurodevelopmental disorders such as growth retardation and intellectual disability. Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c4fa46d3fa59d012ef952212a0a932
https://pubmed.ncbi.nlm.nih.gov/35940133
https://pubmed.ncbi.nlm.nih.gov/35940133
Autor:
Ryohei Umeda, Hitoshi Teranishi, Kazumasa Hada, Nobuyuki Shimizu, Hiroshi Shiraishi, Hirotaro Urushibata, Shaohong Lai, Masahito Shide, Magdeline E. Carrasco Apolinario, Ryoko Higa, Kenshiro Shikano, Toshitaka Shin, Hiromitsu Mimata, Takatoshi Hikida, Toshikatsu Hanada, Reiko Hanada
Publikováno v:
Genes to cells : devoted to molecularcellular mechanismsREFERENCES. 27(4)
Vaccinia-related kinase 2 (VRK2) is a serine/threonine kinase initially identified in highly proliferative cells such as thymocytes and fetal liver cells, and it is involved in cell proliferation and survival. VRK2 is also expressed in the brain; how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef9794f1f73f02c069c4e3e8c972222
https://pubmed.ncbi.nlm.nih.gov/35094457
https://pubmed.ncbi.nlm.nih.gov/35094457