Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Autor: Reijns M. A. M., Parry D. A., Williams T. C., Nadeu F., Hindshaw R. L., Rios Szwed D. O., Nicholson M. D., Carroll P., Boyle S., Royo R., Cornish A. J., Xiang H., Ridout K., Schuh A., Caravagna G, Aden K., Palles C., Campo E., Stankovic T., Taylor M. S., Jackson A. P.

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Reijns, M A M, Parry, D A, Williams, T C, Nadeu, F, Hindshaw, R L, Rios Szwed, D O, Nicholson, M D, Carroll, P, Boyle, S, Royo, R, Cornish, A J, Xiang, H, Ridout, K, Schuh, A, Aden, K, Palles, C, Campo, E & Stankovic, T & Taylor, M S & Jackson, A P 2022, ' Signatures of TOP1 transcription-associated mutagenesis in cancer and germline ', Nature, vol. 602, pp. 623-631 . https://doi.org/10.1038/s41586-022-04403-y

The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair1. In microorganisms, transcription has been demonstrated to be mutagenic2,3; however, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3e84d7c12d168ffbad3ff8ab79514a
https://hdl.handle.net/2117/363117

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.