Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Reiji Teramoto"'
Autor:
Taro Kakuzaki, Hikaru Koga, Shuuki Takizawa, Shoichi Metsugi, Hirotake Shiraiwa, Zenjiro Sampei, Kenji Yoshida, Hiroyuki Tsunoda, Reiji Teramoto
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibodies are one of the predominant treatment modalities for various diseases. To improve the characteristics of a lead antibody, such as antigen-binding affinity and stability, we conducted comprehensive substitutions and exhaustively expl
Externí odkaz:
https://doaj.org/article/464d1ce6486045f391b77c27fa515809
Autor:
Koichiro Saka, Taro Kakuzaki, Shoichi Metsugi, Daiki Kashiwagi, Kenji Yoshida, Manabu Wada, Hiroyuki Tsunoda, Reiji Teramoto
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Molecular evolution is an important step in the development of therapeutic antibodies. However, the current method of affinity maturation is overly costly and labor-intensive because of the repetitive mutation experiments needed to adequatel
Externí odkaz:
https://doaj.org/article/b637d0a8f2934168ad948f2310d11803
Autor:
Shoichi Metsugi, Reiji Teramoto, Hiroyuki Tsunoda, Koichiro Saka, Manabu Wada, Taro Kakuzaki, Daiki Kashiwagi, Kenji Yoshida
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Molecular evolution is an important step in the development of therapeutic antibodies. However, the current method of affinity maturation is overly costly and labor-intensive because of the repetitive mutation experiments needed to adequately explore
Autor:
Daisuke Kobayashi, Attayeb Mohsen, Masakazu Sekijima, Tomoki Ito, M. Michael Gromiha, Masahiro Mochizuki, Mika Sakamoto, Kenji Mizuguchi, Modong Tan, Hideaki Umeyama, Nobuaki Yasuo, Shuntaro Chiba, Shogo Suzuki, Takashi Ishida, Kazuyoshi Ikeda, Daisuke Kihara, Yoshitaka Moriwaki, Yutaka Akiyama, Reiji Teramoto, A. Mary Thangakani, Shintaro Minami, Vipul Gupta, Mitsuo Iwadate, Chioko Nagao, Takaaki Ichikawa, Kazuki Yamamoto, Masahito Ohue, Itsuo Nakane, Kei Yura, Tatsuya Okuno, George Chikenji, Masahiro Kawatani, Kun Yi Hsin, Sakurako Takashina, Takatsugu Hirokawa, Woong-Hee Shin, Devadasan Velmurugan, Hayase Hakariya, Chandrasekaran Ramakrishnan, Ryunosuke Yoshino, Hironori K. Nakamura, Philip Prathipati, Nobuaki Miura, Hiroaki Kitano, Sergey Zozulya, Mari Ito, Akiko Higuchi, Teruki Honma, Petro Borysko, Keita Oda, Anastasiia Gryniukova, Nanako Uchida, Kentaroh Kudoh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library contain
Autor:
Reiji Teramoto1 teramoto@forerunner-pharma.co.jp, Chiaki Saito1 saito@forerunner-pharma.co.jp, Shin-ichi Funahashi1 funahashi@forerunner-pharma.co.jp
Publikováno v:
BMC Bioinformatics. 2014, Vol. 15 Issue 1, p1-28. 28p. 3 Black and White Photographs, 2 Diagrams, 6 Charts, 7 Graphs.
Autor:
Shintaro Minami, Chandrasekaran Ramakrishnan, Petro Borysko, Takashi Ishida, Hideaki Umeyama, M. Michael Gromiha, Shuntaro Chiba, Shogo Suzuki, George Chikenji, Mitsuo Iwadate, A. Mary Thangakani, Masakazu Sekijima, Kazuyoshi Ikeda, Keisuke Yanagisawa, Daisuke Kihara, Y-h. Taguchi, Reiji Teramoto, Sergey Zozulya, Devadasan Velmurugan, Woong-Hee Shin, Tatsuya Okuno, Teruki Honma, Masahiro Mochizuki, Kazuki Yamamoto, Yoshitaka Moriwaki, Takatsugu Hirokawa, Ryunosuke Yoshino, Roman Stavniichuk, Yutaka Akiyama, Nobuaki Yasuo, Koya Kato
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
We propose a new iterative screening contest method to identify target protein inhibitors. After conducting a compound screening contest in 2014, we report results acquired from a contest held in 2015 in this study. Our aims were to identify target e
Autor:
Hiroaki Kitano, Yuko Tsuchiya, Kun-Yi Hsin, Teruki Honma, Takashi Ishida, Kenji Mizuguchi, Chandrasekaran Ramakrishnan, Devadasan Velmurugan, Masahiro Mochizuki, A. Mary Thangakani, Shuntaro Chiba, Ito Junichi, Keisuke Yanagisawa, Tomohiro Ban, Hideaki Umeyama, Koya Kato, Yutaka Akiyama, George Chikenji, Masakazu Sekijima, Kazuyoshi Ikeda, Y-h. Taguchi, Reiji Teramoto, Nobuaki Yasuo, M. Michael Gromiha, Ryunosuke Yoshino, Tatsuya Okuno, Kazuki Yamamoto, Nobuyoshi Sugaya, Takatsugu Hirokawa, Philip Prathipati, Mitsuo Iwadate
Publikováno v:
Scientific Reports
A search of broader range of chemical space is important for drug discovery. Different methods of computer-aided drug discovery (CADD) are known to propose compounds in different chemical spaces as hit molecules for the same target protein. This stud
Autor:
Tsuyoshi Kato, Reiji Teramoto
Publikováno v:
Journal of Bioinformatics and Computational Biology. :521-540
In the drug discovery process, the metabolic fate of drugs is crucially important to prevent drug–drug interactions. Therefore, P450 isozyme selectivity prediction is an important task for screening drugs of appropriate metabolism profiles. Recentl
Autor:
Hisashi Kashima, Reiji Teramoto
Publikováno v:
Journal of Molecular Graphics and Modelling. 29:492-497
Accurate prediction of protein–ligand binding affinities for lead optimization in drug discovery remains an important and challenging problem on scoring functions for docking simulation. In this paper, we propose a data-driven approach that integra
Autor:
Yo Tabuse, Masao Honda, Kenichi Kamijo, Reiji Teramoto, Kenji Miyazaki, Hirotaka Minagawa, Shuichi Kaneko, Teruyuki Ueda
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1784:764-772
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies. Although several major risks related to HCC, e.g., hepatitis B and/or hepatitis C virus infection, aflatoxin B1 exposure, alcohol drinking and genetic defects