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Heterogeneous endocrine cell composition defines human islet functional phenotypes.

Autor: Evans-Molina C; Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Departments of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Departments of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Departments of Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Departments of Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA., Pettway YD; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Saunders DC; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Sharp SA; Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA., Bate TS; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Sun H; Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA., Durai H; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Mei S; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Coldren A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Davis C; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Reihsmann CV; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hopkirk AL; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Taylor J; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Bradley A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Aramandla R; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Poffenberger G; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Eskaros A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Jenkins R; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Shi D; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Kang H; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Rajesh V; Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA., Thaman S; Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA., Feng F; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Cartailler JP; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA., Powers AC; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; VA Tennessee Valley Healthcare System, Nashville, TN 37232, USA., Abraham K; Division of Diabetes, Endocrinology, & Metabolic Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Gloyn AL; Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA.; Stanford Diabetes Center, Stanford School of Medicine, Stanford, CA, USA., Niland JC; Department of Diabetes and Cancer Discovery Science, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA., Brissova M; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.