Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

Autor: Reyes-Ortiz, Andrea M., Abud, Edsel M., Burns, Mara S., Wu, Jie, Hernandez, Sarah J., McClure, Nicolette, Wang, Keona Q., Schulz, Corey J., Miramontes, Ricardo, Lau, Alice, Michael, Neethu, Miyoshi, Emily, Van Vactor, David, Reidling, John C., Blurton-Jones, Mathew, Swarup, Vivek, Poon, Wayne W., Lim, Ryan G., Thompson, Leslie M.

Publikováno v: In iScience 20 January 2023 26(1)

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits.

Autor: Reyes-Ortiz AM; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92617, USA., Abud EM; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92617, USA., Burns MS; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92617, USA., Wu J; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92617, USA., Hernandez SJ; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92617, USA., McClure N; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92617, USA., Wang KQ; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92617, USA., Schulz CJ; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92617, USA., Miramontes R; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92617, USA., Lau A; Department of Psychiatry & Human Behavior, University of California, Irvine, Irvine, CA 92617, USA., Michael N; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92617, USA., Miyoshi E; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92617, USA., Van Vactor D; Harvard Medical School, Department of Cell Biology, Boston, MA 02115, USA., Reidling JC; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92617, USA., Blurton-Jones M; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92617, USA.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92617, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92617, USA., Swarup V; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92617, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92617, USA., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92617, USA., Lim RG; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92617, USA., Thompson LM; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92617, USA.; Department of Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92617, USA.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92617, USA.; Department of Psychiatry & Human Behavior, University of California, Irvine, Irvine, CA 92617, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92617, USA.

Publikováno v: IScience [iScience] 2022 Dec 06; Vol. 26 (1), pp. 105732. Date of Electronic Publication: 2022 Dec 06 (Print Publication: 2023).