Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Reidar, Grenman"'
Autor:
Ahmed Al-Samadi, Katja Tuomainen, Anne Kivimäki, Abdelhakim Salem, Sakhr Al-Kubati, Aini Hyytiäinen, Mataleena Parikka, Karri Mesimäki, Tommy Wilkman, Antti Mäkitie, Reidar Grenman, Tuula Salo
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-6 (2019)
Abstract Background Currently, in vivo model for personalised cancer drug testing is challenging. A zebrafish larvae xenograft model has been applied in recent years to cancer research, particularly for drug testing purposes, showing promising result
Externí odkaz:
https://doaj.org/article/82e9f47114a541f2941ddf4f5511e016
Autor:
Julia Odenthal, Mark Rijpkema, Desirée Bos, Esther Wagena, Huib Croes, Reidar Grenman, Otto Boerman, Robert Takes, Peter Friedl
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Head and neck squamous cell carcinoma (HNSCC) is an often highly invasive tumor, infiltrating functionally important tissue areas. Achieving complete tumor resection and preserving functionally relevant tissue structures depends on precise i
Externí odkaz:
https://doaj.org/article/5321e473c5864bbd8857687f41fc9e44
Autor:
Joanna Janiszewska, Magdalena Bodnar, Julia Paczkowska, Adam Ustaszewski, Maciej J. Smialek, Lukasz Szylberg, Andrzej Marszalek, Katarzyna Kiwerska, Reidar Grenman, Krzysztof Szyfter, Malgorzata Wierzbicka, Maciej Giefing, Malgorzata Jarmuz-Szymczak
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 1035 (2021)
MAF is a transcription factor that may act either as a tumor suppressor or as an oncogene, depending on cell type. We have shown previously that the overexpressed miR-1290 influences MAF protein levels in LSCC (laryngeal squamous cell carcinoma) cell
Externí odkaz:
https://doaj.org/article/f51bcf269eb0438fa7a2525d3f109e91
Autor:
Katarzyna Kiwerska, Marcin Szaumkessel, Julia Paczkowska, Magdalena Bodnar, Ewa Byzia, Ewelina Kowal, Magdalena Kostrzewska-Poczekaj, Joanna Janiszewska, Kinga Bednarek, Małgorzata Jarmuż-Szymczak, Ewelina Kalinowicz, Małgorzata Wierzbicka, Reidar Grenman, Krzysztof Szyfter, Andrzej Marszałek, Maciej Giefing
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Larynx squamous cell carcinoma (LSCC) is characterized by complex genotypes, with numerous abnormalities in various genes. Despite the progress in diagnosis and treatment of this disease, 5-year survival rates remain unsatisfactory. Therefor
Externí odkaz:
https://doaj.org/article/f5cb676038514a8f9b6a3fd796b3b2b4
Autor:
Riina Kaukonen, Anja Mai, Maria Georgiadou, Markku Saari, Nicola De Franceschi, Timo Betz, Harri Sihto, Sami Ventelä, Laura Elo, Eija Jokitalo, Jukka Westermarck, Pirkko-Liisa Kellokumpu-Lehtinen, Heikki Joensuu, Reidar Grenman, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
The tumour stroma has altered stiffness and matrix architecture compared to normal tissue, which favours proliferation, and invasion. Here, the authors find that the extracellular matrix produced by normal fibroblasts inhibits cancer cell proliferati
Externí odkaz:
https://doaj.org/article/1ebfc9741f164d8f95d19712978bfaf4
Autor:
Panu M. Jaakkola, Veli-Matti Kähäri, Reidar Grenman, Terhi Jokilehto, Marika Nummela, Pekka T. Heikkinen
Supplementary Table 1 from Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b736386fa51b2c8a8d1e8e247bca9a7
https://doi.org/10.1158/0008-5472.22382616
https://doi.org/10.1158/0008-5472.22382616
Autor:
Panu M. Jaakkola, Veli-Matti Kähäri, Reidar Grenman, Terhi Jokilehto, Marika Nummela, Pekka T. Heikkinen
Supplementary Figures 1-8 from Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1333cebdde82da9cc99875636badf0
https://doi.org/10.1158/0008-5472.22382622
https://doi.org/10.1158/0008-5472.22382622
Autor:
Panu M. Jaakkola, Veli-Matti Kähäri, Reidar Grenman, Terhi Jokilehto, Marika Nummela, Pekka T. Heikkinen
Supplementary Figure Legends 1-8 from Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66aa97c9094d1828d52d85565932a56e
https://doi.org/10.1158/0008-5472.22382625.v1
https://doi.org/10.1158/0008-5472.22382625.v1
Autor:
Panu M. Jaakkola, Veli-Matti Kähäri, Reidar Grenman, Terhi Jokilehto, Marika Nummela, Pekka T. Heikkinen
Smad7 is an inhibitor of the transforming growth factor-β–activated signaling pathway. Under well-oxygenated conditions, Smad7 is a potent inhibitor of carcinoma cell invasion. Paradoxically, however, the expression of Smad7 is upregulated across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a352aaaf90d13cc9d502c441b83cda5
https://doi.org/10.1158/0008-5472.c.6500265
https://doi.org/10.1158/0008-5472.c.6500265
Autor:
Marcin Szaumkessel, Sonia Wojciechowska, Joanna Janiszewska, Natalia Zemke, Ewa Byzia, Katarzyna Kiwerska, Magdalena Kostrzewska-Poczekaj, Adam Ustaszewski, Malgorzata Jarmuz-Szymczak, Reidar Grenman, Malgorzata Wierzbicka, Anna Bartochowska, Krzysztof Szyfter, Maciej Giefing
Publikováno v:
Tumor Biology, Vol 39 (2017)
Cellular processes like differentiation, mitotic cycle, and cell growth are regulated by tyrosine kinases with known oncogenic potential and tyrosine phosphatases that downmodulate the first. Therefore, tyrosine phosphatases are recurrent targets of
Externí odkaz:
https://doaj.org/article/d76192299076402097c801f3fd53b3ae