Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Reid W. von Borstel"'
Autor:
Joel A. Saydoff, Rolando A.G. Garcia, Susan E. Browne, Liansheng Liu, Jin Sheng, Denise Brenneman, Zhongyi Hu, Sylvain Cardin, Alexis Gonzalez, Reid W. von Borstel, Jason Gregorio, Holly Burr, M. Flint Beal
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 3, Pp 455-465 (2006)
Previously, uridine pro-drug 2′,3′,5′-tri-O-acetyluridine (PN401) was shown to be protective in the mitochondrial complex II inhibitor 3-nitropropionic acid model of Huntington's disease (HD). In this study, PN401 increased survival and improve
Externí odkaz:
https://doaj.org/article/af8ec1366eed4784b770dcc6d779fe9a
Publikováno v:
Toxicology and Applied Pharmacology. 353:67-73
Uridine triacetate has been shown to be an effective antidote against mortality and toxicity caused by either overdoses or exaggerated susceptibility to the widely used anticancer agents 5-fluorouracil (5-FU) and capecitabine. However, a direct asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a367b6f1c2aa0cba0b9f334cc2b6f86a
https://doi.org/10.1016/j.taap.2018.06.012
https://doi.org/10.1016/j.taap.2018.06.012
Autor:
Joel A. Saydoff, Rolando Garcia, Zhong-Yi Hu, Ana Olariu, Jiong Pei, Reid W. von Borstel, Grace Y. Sun, Qin Li, Jin Sheng
Publikováno v:
Journal of Alzheimer's Disease. 36:637-657
Uridine prodrug PN401 has been shown to have neuroprotective effects in models of Parkinson's disease and Huntington's disease. These age-related neurodegenerative diseases including Alzheimer's disease (AD) are associated with mitochondrial dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930925cc5f32713c9601fe90f7dfa3b6
https://doi.org/10.3233/jad-130059
https://doi.org/10.3233/jad-130059
Autor:
Holly Burr, Sylvain Cardin, Liansheng Liu, Reid W. von Borstel, Zhongyi Hu, Susan E. Browne, Denise Brenneman, Jason Gregorio, Jin Sheng, Rolando Garcia, M. Flint Beal, Joel A. Saydoff, Alexis Gonzalez
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 3, Pp 455-465 (2006)
Previously, uridine pro-drug 2',3',5'-tri-O-acetyluridine (PN401) was shown to be protective in the mitochondrial complex II inhibitor 3-nitropropionic acid model of Huntington's disease (HD). In this study, PN401 increased survival and improved moto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eaf238c7d5d84bffa34590087c0962f
https://doi.org/10.1016/j.nbd.2006.08.011
https://doi.org/10.1016/j.nbd.2006.08.011
Publikováno v:
Brain Research. 994:44-54
Huntington's disease (HD) is associated with decreased activity of mitochondrial succinate dehydrogenase (complex II). De novo biosynthesis of uridine nucleotides is directly coupled to the respiratory chain. Cells with impaired mitochondrial functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee37a213aea60069b27086773702095
https://doi.org/10.1016/j.brainres.2003.09.049
https://doi.org/10.1016/j.brainres.2003.09.049
Autor:
Oksana Iavorovska, R. C. von Borstel, Carrie L. DeHaan, Barry J. Barclay, Reid W. von Borstel, Ursula G.G. Hennig
Publikováno v:
Environmental and Molecular Mutagenesis. 38:153-158
There is a need for a rapid assay to identify agents that damage mitochondria because the mitochondrion may be an important target for numerous environmental mitotoxins. Certainly at least one chemotherapeutic regimen (CHOP therapy) that includes dox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe737b8dfd3d7865869160c4fdc881e
https://doi.org/10.1002/em.1066
https://doi.org/10.1002/em.1066
Autor:
Thomas H. Cartwright, Wasif M. Saif, Bassel F. El-Rayes, Reid W. von Borstel, Wen Wee Ma, Marwan Fakih, Julie Vanas, Michael K. Bamat, James Posey, Thomas King
Publikováno v:
Journal of Clinical Oncology. 34:e21689-e21689
e21689Background: Uridine triacetate was approved by FDA in 2015 for adult and pediatric patients who exhibit early-onset, severe or life-threatening toxicities or who receive an overdose of 5-fluo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ec887398d9bc08e815517cd3245c8f6
https://doi.org/10.1200/jco.2016.34.15_suppl.e21689
https://doi.org/10.1200/jco.2016.34.15_suppl.e21689
Publikováno v:
Journal of Clinical Oncology. 34:e18232-e18232
e18232Background: Oral uridine triacetate improves survival and reduces toxicity when administered after serious overdoses of 5-fluorouracil (5-FU) in preclinical animal models and in humans. It ac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba79cbde34157476911891b2d3f11b86
https://doi.org/10.1200/jco.2016.34.15_suppl.e18232
https://doi.org/10.1200/jco.2016.34.15_suppl.e18232
Autor:
Bassel F. El-Rayes, Wen Wee Ma, James Posey, Thomas King, Michael K. Bamat, Reid W. von Borstel, Marwan Fakih, Thomas H. Cartwright
Publikováno v:
Journal of Clinical Oncology. 34:e21612-e21612
e21612Background: Uridine triacetate was approved by FDA in 2015 for adult and pediatric patients who receive an overdose of 5-fluorouracil or capecitabine or who exhibit early-onset, severe or lif...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e7f054be6426052fb2a84ee0c7480e1
https://doi.org/10.1200/jco.2016.34.15_suppl.e21612
https://doi.org/10.1200/jco.2016.34.15_suppl.e21612
Autor:
Thomas H. Cartwright, Bassel F. El-Rayes, Wasif M. Saif, Marwan Fakih, James Posey, Michael K. Bamat, Reid W. von Borstel, Wen Wee Ma
Publikováno v:
Journal of Clinical Oncology. 34:655-655
655 Background: Life-threatening or lethal 5-FU toxicity occurs due to infusion pump/reservoir errors and 5-FU dosage miscalculations. Additionally, DPD-deficient patients often experience serious or lethal toxicity. Regardless of DPD status, some pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c10d651cf25d3683cbcf38cd0cb84e
https://doi.org/10.1200/jco.2016.34.4_suppl.655
https://doi.org/10.1200/jco.2016.34.4_suppl.655