Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Reid M. McCarty"'
Publikováno v:
Journal of the American Chemical Society. 139:16084-16087
Many cobalamin (Cbl)-dependent radical S-adenosyl-L-methionine (SAM) methyltransferases have been identified through sequence alignment and/or genetic analysis; however, few have been studied in vitro. GenK is one such enzyme that catalyzes methylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b29ec1a9b39447b9c2f41c4fa15434
https://doi.org/10.1021/jacs.7b09890
https://doi.org/10.1021/jacs.7b09890
Publikováno v:
Angewandte Chemie. 129:3498-3542
Chemische Reaktionen, die zu Ehren ihrer wahren oder zumindest wahrgenommenen Entdecker benannt sind, werden als “Namensreaktionen” bezeichnet. Dieser Aufsatz ist eine Zusammenstellung von biologischen Beispielen fur benannte chemische Reaktionen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fad54158af69520a042b9237a9f019b8
https://doi.org/10.1002/ange.201603291
https://doi.org/10.1002/ange.201603291
Autor:
Nathan A. Bruender, Daniel P. Dowling, Vahe Bandarian, Catherine L. Drennan, Tsehai A.J. Grell, Reid M. McCarty
Publikováno v:
Journal of the American Chemical Society
Radical S-adenosyl-l-methionine (SAM) enzymes are widely distributed and catalyze diverse reactions. SAM binds to the unique iron atom of a site-differentiated [4Fe-4S] cluster and is reductively cleaved to generate a 5′-deoxyadenosyl radical, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc78ad4a0e6944aa7057c0bbade7dd9
https://doi.org/10.1021/jacs.6b11381
https://doi.org/10.1021/jacs.6b11381
Chemical reactions that are named in honor of their true, or at least perceived, discoverers are known as "name reactions". This Review is a collection of biological representatives of named chemical reactions. Emphasis is placed on reaction types an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf8770470a722ba5b1a5441190ce13c
https://europepmc.org/articles/PMC5477795/
https://europepmc.org/articles/PMC5477795/
Publikováno v:
Journal of Biological Chemistry. 289:23641-23652
6-Pyruvoyltetrahydropterin synthase (PTPS) homologs in both mammals and bacteria catalyze distinct reactions using the same 7,8-dihydroneopterin triphosphate substrate. The mammalian enzyme converts 7,8-dihydroneopterin triphosphate to 6-pyruvoyltetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086aa41e04d3cc5a0a2fea518e300be1
https://doi.org/10.1074/jbc.m114.555680
https://doi.org/10.1074/jbc.m114.555680
Autor:
Vahe Bandarian, Daniel P. Dowling, Anthony P. Young, Reid M. McCarty, Catherine L. Drennan, Nathan A. Bruender
Publikováno v:
Nature chemical biology
7-Carboxy-7-deazaguanine synthase (QueE) catalyzes a key S-adenosyl-L-methionine (AdoMet)- and Mg2+-dependent radical-mediated ring contraction step, which is common to the biosynthetic pathways of all deazapurine-containing compounds. QueE is a memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba3d40c75b860d00d3a37615ca1e2a4
https://doi.org/10.1038/nchembio.1426
https://doi.org/10.1038/nchembio.1426
Autor:
Jake LeVieux, Reid M. McCarty, Steven O. Mansoorabadi, Yung Nan Liu, Yasushi Ogasawara, Hak Joong Kim, Hung-wen Liu
Publikováno v:
Journal of the American Chemical Society. 135:8093-8096
The existence of cobalamin (Cbl)-dependent enzymes that are members of the radical S-adenosyl-l-methionine (SAM) superfamily was previously predicted on the basis of bioinformatic analysis. A number of these are Cbl-dependent methyltransferases, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f61af5a1ec3f49baf164fc3f018f5f
https://doi.org/10.1021/ja312641f
https://doi.org/10.1021/ja312641f
Publikováno v:
Biochemistry. 52:188-198
7-Carboxy-7-deazaguanine (CDG) synthase (QueE) catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH(4)) to CDG in the third step of the biosynthetic pathway to all 7-deazapurines. Here we present a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fb382a5e4d5254b27dbe2613aa50b0
https://doi.org/10.1021/bi301156w
https://doi.org/10.1021/bi301156w
Autor:
Reid M. McCarty, Vahe Bandarian
Publikováno v:
Bioorganic Chemistry. 43:15-25
Pyrrolopyrimidine containing compounds, also known as 7-deazapurines, are a collection of purine-based metabolites that have been isolated from a variety of biological sources and have diverse functions which range from secondary metabolism to RNA mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582dadc20afa33ee108f9e150958b1e1
https://doi.org/10.1016/j.bioorg.2012.01.001
https://doi.org/10.1016/j.bioorg.2012.01.001
Publikováno v:
Proceedings of the National Academy of Sciences. 108:7368-7372
Transfer RNA is one of the most richly modified biological molecules. Biosynthetic pathways that introduce these modifications are underexplored, largely because their absence does not lead to obvious phenotypes under normal growth conditions. Queuos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d8eca534f7c302dcb29e54022e97cf
https://doi.org/10.1073/pnas.1018636108
https://doi.org/10.1073/pnas.1018636108