Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Reid J. Leonard"'
Autor:
Sheng-Shung Pong, Scott D. Feighner, Carina P. Tan, Alex R. T. Bailey, Reid J. Leonard, Karen K. McKee, Roy G. Smith, Andrew D. Howard, Oksana C. Palyha, Patrick R. Griffin
Publikováno v:
Endocrine. 14:009-014
We have previously reported the cloning and characterization of a new orphan G-protein-coupled receptor (GPC-R), the growth hormone secretagogue receptor (GHS-R), and shown that this receptor mediates the activity of the growth hormone-releasing pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95507c1168e6be370df2f778f5a2c2f
https://doi.org/10.1385/endo:14:1:009
https://doi.org/10.1385/endo:14:1:009
Autor:
Hans-Günther Knaus, Siegmund G. Wanner, Maria L. Garcia, Reid J. Leonard, John P. Felix, Gregory J. Kaczorowski, Randal M. Bugianesi, Robert O. A. Koch, Scott P. Stevens, Lisa M. H. Helms, Robert S. Slaughter
Publikováno v:
Biochemistry. 36:3737-3744
Voltage-gated potassium (K(V)) channels play key roles in setting the resting potential and in the activation cascade of human peripheral T lymphocytes. Margatoxin (MgTX), a 39-amino acid peptide from Centruroides margaritatus, is a potent inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0a880467e6b335261e03716c0f3af7
https://doi.org/10.1021/bi962351p
https://doi.org/10.1021/bi962351p
Publikováno v:
Biochemical and Biophysical Research Communications. 198:619-625
The 39 amino acid peptide, margatoxin (MgTX), a potent inhibitor of the voltage-activated potassium channel (Kv1.3) in human T lymphocytes, was synthesized by a solid phase technique. Formation of the disulfide bridges was rapid at pH 8.2. The final
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bee3db48a6e4e09d991c93deed07744
https://doi.org/10.1006/bbrc.1994.1090
https://doi.org/10.1006/bbrc.1994.1090
Autor:
Margarita Garcia-Calvo, William A. Schmalhofer, Gregory J. Kaczorowski, Scott P. Stevens, Reid J. Leonard, J Novick, Maria L. Garcia
Publikováno v:
Journal of Biological Chemistry. 268:18866-18874
A novel peptidyl inhibitor of K+ channels has been purified to homogeneity from venom of the new world scorpion Centruroides margaritatus. The primary structure of this 39-amino-acid peptide, which we term margatoxin (MgTX), was determined by amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbf95b705577a67696609c9608820602
https://doi.org/10.1016/s0021-9258(17)46707-x
https://doi.org/10.1016/s0021-9258(17)46707-x
Autor:
Reid J. Leonard, Maria L. Garcia, Gregory J. Kaczorowski, Margarita Garcia-Calvo, Elizabeth E. Sugg, Kathleen M. Giangiacomo, Owen B. McManus
Publikováno v:
Biochemistry. 32:2363-2370
Charybdotoxin (ChTX) and iberiotoxin (IbTX) are highly charged peptidyl toxins which exhibit 68% sequence identity and share a similar three-dimensional structure. Despite these structural similarities, IbTX and ChTX differ in their selectivity for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6ea95cd739157e8986870fcbb87c32
https://doi.org/10.1021/bi00060a030
https://doi.org/10.1021/bi00060a030
Publikováno v:
Molecular Brain Research. 10:203-211
This report analyzes the contribution of individual nicotinic acetylcholine receptor (AChR) subunits to the single-channel properties of the AChR ion channel. By in vitro synthesis of mRNA from cDNA clones encoding each AChR subunit (alpha, beta, gam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c00a41e5bb665fd70a7b4f62902cf8
https://doi.org/10.1016/0169-328x(91)90062-3
https://doi.org/10.1016/0169-328x(91)90062-3
Autor:
Annie Gouin, P. Charnet, Henry A. Lester, Norman Davidson, Cesar Labarca, Reid J. Leonard, Linda Czyzyk, Nancy J. Vogelaar
Publikováno v:
Annals of the New York Academy of Sciences. 625:588-599
We have been examining the interaction of a local anesthetic derivative, QX-222, with the ion channel pore of the muscle AChR, using a combination of mutagenesis, oocyte expression, and electrophysiology. Single channel recording, together with macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e835d38c38df7fe6d256c5cc80536da8
https://doi.org/10.1111/j.1749-6632.1991.tb33894.x
https://doi.org/10.1111/j.1749-6632.1991.tb33894.x
Autor:
Denis Leong, Reid J. Leonard, Roy G. Smith, Kang Cheng, Anna Pomés, Patrick R. Griffin, James M. Schaeffer, Alexander G.A. Smith, Jimmy Calacay, Ken Liu, Lex H.T. Van der Ploeg, Scott D. Feighner, C.-S. Pong, Yuan Xu, Andrew D. Howard
Publikováno v:
Biochemical and biophysical research communications. 276(3)
The growth hormone secretagogue receptor (GHS-R) is involved in the regulation of pulsatile GH release. However, until recently, natural endogenous ligands for the receptor were unknown. We fractionated porcine hypothalamic extracts and assayed fract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc4d4de5b212894cf943bf3c30acab3
https://pubmed.ncbi.nlm.nih.gov/11027627
https://pubmed.ncbi.nlm.nih.gov/11027627
Autor:
Owen B. McManus, Reid J. Leonard, Hans-Günther Knaus, Gregory J. Kaczorowski, Maria L. Garcia
Publikováno v:
Journal of bioenergetics and biomembranes. 28(3)
High-conductance calcium-activated potassium (maxi-K) channels comprise a specialized family of K+ channels. They are unique in their dual requirement for depolarization and Ca2+ binding for transition to the open, or conducting, state. Ion conductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a881c3e03e0a13dc1ef1fc3db9c0f26
https://pubmed.ncbi.nlm.nih.gov/8807400
https://pubmed.ncbi.nlm.nih.gov/8807400
Autor:
Gerard J. Hickey, Kang Cheng, C. H. Chang, Suzanne L. Dickson, Sheng-Shung Pong, Joseph P. Arena, Reid J. Leonard, Charles J. Cohen, Tom Jacks, Drisko J, Roy G. Smith, Iain C. A. F. Robinson, Gareth Leng
Publikováno v:
Growth Hormone Secretagogues ISBN: 9781461275268
Growth hormone (GH) secretion from the pituitary gland is regulated by the hypothalamic peptide hormones growth hormone releasing hormone (GHRH) and somatotropin release inhibiting factor (SRIF) (Scheme 11.1). The factor controlling the episodic natu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1817fa1cdcb5104d35e67b91d3ae4f1e
https://doi.org/10.1007/978-1-4612-2396-2_11
https://doi.org/10.1007/978-1-4612-2396-2_11
