Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Reid H J, Olsen"'
Autor:
Amal El Daibani, Joseph M. Paggi, Kuglae Kim, Yianni D. Laloudakis, Petr Popov, Sarah M. Bernhard, Brian E. Krumm, Reid H. J. Olsen, Jeffrey Diberto, F. Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O. Dror, Tao Che
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.
Externí odkaz:
https://doaj.org/article/937c35a4ce1e4c9d8b16be30f0910f0c
Autor:
Tao Che, Justin English, Brian E. Krumm, Kuglae Kim, Els Pardon, Reid H. J. Olsen, Sheng Wang, Shicheng Zhang, Jeffrey F. Diberto, Noah Sciaky, F. Ivy Carroll, Jan Steyaert, Daniel Wacker, Bryan L. Roth
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized stat
Externí odkaz:
https://doaj.org/article/ea2f79e5cad94be58517658c2739cb15
Autor:
Brian E. Krumm, Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang, Ryan T. Strachan, Xi-Ping Huang, Lauren M. Slosky, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron, Terry Kenakin, Jonathan F. Fay, Bryan L. Roth
Publikováno v:
Biochemistry. 62:1233-1248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e46ba96106037966aa36314ed803bd6d
https://doi.org/10.1021/acs.biochem.3c00029
https://doi.org/10.1021/acs.biochem.3c00029
Autor:
Claire Shepherd, Sean Robinson, Alice Berizzi, Laura E. J. Thompson, Louise Bird, Simone Culurgioni, Simon Varzandeh, Philip B. Rawlins, Reid H. J. Olsen, Iva Hopkins Navratilova
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1172-1181
Surface plasmon resonance (SPR) is a widely used method to study ligand-protein interactions. The throughput and sensitivity of SPR has made it an important technology for measuring low-affinity, ultralow weight fragments (200 Da) in the early stages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e66d06a32facffe55631486a1bf732
https://doi.org/10.1021/acsmedchemlett.2c00099
https://doi.org/10.1021/acsmedchemlett.2c00099
Autor:
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A. Martin, Ajit Prakash, Jeffrey F. DiBerto, Kevin M. Knight, Soumadwip Ghosh, Reid H. J. Olsen, Bryan L. Roth, J. Silvio Gutkind, Nagarajan Vaidehi, Sharon L. Campbell, Henrik G. Dohlman
Publikováno v:
Sci Signal
Heterotrimeric guanine nucleotide–binding proteins (G proteins) that function as molecular switches for cellular growth and metabolism are activated by GTP and inactivated by GTP hydrolysis. In uveal melanoma, a conserved glutamine residue critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d826b894becd7f7b7fd4f5b9cd98a9b
https://doi.org/10.1126/scisignal.abq7842
https://doi.org/10.1126/scisignal.abq7842
Autor:
Brian E. Krumm, Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang, Ryan T. Strachan, Lauren M. Slosky, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron, Terry Kenakin, Jonathan F. Fay, Bryan L. Roth
SUMMARYThe NTSR1 neurotensin receptor (NTSR1) is a G protein coupled receptor (GPCR) found in the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide ligand. In the brain, NTS modulates dopamine neuronal activity, induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f8f9a1b8e405f18eeb9bd5e4602a8f
https://doi.org/10.1101/2022.12.26.521971
https://doi.org/10.1101/2022.12.26.521971
Autor:
Ovidiu Dan Iancu, Sydney Weber Boutros, Reid H. J. Olsen, Matthew J. Davis, Blair Stewart, Massarra Eiwaz, Tessa Marzulla, John Belknap, Christina M. Fallgren, Elijah F. Edmondson, Michael M. Weil, Jacob Raber
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Behavioral and cognitive traits have a genetic component even though contributions from individual genes and genomic loci are in many cases modest. Changes in the environment can alter genotype–phenotype relationships. Space travel, which includes
Externí odkaz:
https://doaj.org/article/209d0684f8ca4f228ddcf6f241fed465
Autor:
Reid H. J. Olsen, Justin G. English
Publikováno v:
British journal of pharmacologyREFERENCES.
Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in the human body, are plentiful and var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157fc5706efabadb7676f62616a997a2
https://pubmed.ncbi.nlm.nih.gov/36166832
https://pubmed.ncbi.nlm.nih.gov/36166832
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2525
G protein-coupled receptors (GPCRs) are the most highly targeted protein family by United States Food and Drug Administration-approved drugs. Despite their historic and continued importance as drug targets, their therapeutic potential remains underex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c4597a4ae66b095e0d7239112fae79f
https://pubmed.ncbi.nlm.nih.gov/35836068
https://pubmed.ncbi.nlm.nih.gov/35836068
Publikováno v:
Bioluminescence ISBN: 9781071624722
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a53f80cb394cb2ad77f2362975f1420
https://doi.org/10.1007/978-1-0716-2473-9_13
https://doi.org/10.1007/978-1-0716-2473-9_13