Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.

Autor: Zaidi SH; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Phipps AI; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Steinfelder R; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Trinh QM; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Qu C; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Banbury BL; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Georgeson P; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia., Grasso CS; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.; Department of Surgery, Cedar Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA., Giannakis M; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA., Adams JB; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Alwers E; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Amitay EL; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Barfield RT; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Borozan I; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Brezina S; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschekagasse 8a, 1090, Vienna, Austria., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia., Cao Y; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, 02114, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.; Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Chan AT; Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, 02114, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Avenue, Boston, MA, 02115, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Avenue, Boston, MA, 02115, USA., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), 20246, Hamburg, Germany., Connolly CM; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Drew DA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, 02114, USA.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA., Farris AB 3rd; Pathology and Laboratory Medicine, Emory University School of Medicine, 1364 Clifton Rd. NE, Atlanta, GA, 30322, USA., Figueiredo JC; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., French AJ; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Fuchs CS; Yale Cancer Center, 333 Cedar St, New Haven, CT, 06510, USA.; Department of Medicine, Yale School of Medicine, New Haven, CT, USA.; Smilow Cancer Hospital, New Haven, CT, USA., Garraway LA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA., Gruber S; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA, 90089, USA., Guinter MA; Behavioral and Epidemiology Research Group, American Cancer Society, 250 Williams St NW, Atlanta, GA, 30303, USA., Hamilton SR; City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, 91010, USA., Harlid S; Department of Radiation Sciences, Oncology Unit, Umeå University, SE-901 87, Umeå, Sweden., Heisler LE; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Hidaka A; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Hopper JL; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia., Huang WY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Huyghe JR; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3010, Australia., Krzyzanowski PM; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Lemire M; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Lin Y; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Luo X; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Mardis ER; Institute for Genomic Medicine, Nationwide Children's Hospital and The Ohio State University College of Medicine, 575 Children's Crossroad, Columbus, OH, 43215, USA., McPherson JD; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.; Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, 2700 Stockton Blvd, Sacramento, CA, 95817, USA., Miller JK; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Moreno V; Oncology Data Analytics Program, Catalan Institute of Oncology and ONCOBELL Program, IDIBELL, Avinguda de la Granvia de l'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, 08907, Barcelona, Spain., Mu XJ; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA., Nishihara R; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Papadopoulos N; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Institution, 1650 Orleans Street, Baltimore, MD, 21231, USA., Pasternack D; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Quist MJ; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Rafikova A; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Reid EEG; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Shinbrot E; Human Genome Sequencing Centre, Baylor College of Medicine, One Baylor Plaza, Alkek N1419, Houston, TX, 77030, USA., Shirts BH; Department of Laboratory Medicine, University of Washington, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA, 98195, USA., Stein LD; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Teney CD; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Timms L; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Um CY; Behavioral and Epidemiology Research Group, American Cancer Society, 250 Williams St NW, Atlanta, GA, 30303, USA., Van Guelpen B; Department of Radiation Sciences, Oncology Unit, Umeå University, SE-901 87, Umeå, Sweden.; Wallenberg Centre for Molecular Medicine, Umeå University, SE-901 87, Umeå, Sweden., Van Tassel M; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Wang X; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Wheeler DA; Human Genome Sequencing Centre, Baylor College of Medicine, One Baylor Plaza, Alkek N1419, Houston, TX, 77030, USA., Yung CK; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.; Department of Biostatistics, University of Washington, Seattle, WA, USA., Ogino S; Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Avenue, Boston, MA, 02115, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA., Gsur A; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschekagasse 8a, 1090, Vienna, Austria., Newcomb PA; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Gallinger S; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.; Department of Surgery, University Health Network Toronto General Hospital, Toronto, ON, Canada., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Campbell PT; Behavioral and Epidemiology Research Group, American Cancer Society, 250 Williams St NW, Atlanta, GA, 30303, USA., Thibodeau SN; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA., Sun W; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA., Hudson TJ; Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA. upeters@fredhutch.org.; Department of Epidemiology, University of Washington, Seattle, WA, USA. upeters@fredhutch.org.

Publikováno v: Nature communications [Nat Commun] 2020 Jul 20; Vol. 11 (1), pp. 3644. Date of Electronic Publication: 2020 Jul 20.