Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Rei Okamoto"'
Autor:
Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, Thomas Tuschl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in inte
Externí odkaz:
https://doaj.org/article/6f06ae155ca2436dab39b0d693daf384
Autor:
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor a
Externí odkaz:
https://doaj.org/article/2885ccbed5fa465f9f9e037a1d7866c1
Autor:
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
The previously published version of this Article contained errors in Fig. 6. In panel h the units of the x axis were incorrectly given as mM and should have been given as µM. Also, the IC50s for RU.365, RU.332 and RU.521 within panel h were incorrec
Externí odkaz:
https://doaj.org/article/920c5aa0d55044bb8e7799f3d44a9730
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Annie Leung, Yi J. Liu, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Mayako Michino, Takafumi Yukawa, Sevil Chelebieva, Patrick K. Tumwebaze, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Philip J. Rosenthal, Roland A. Cooper, Nigel Liverton, Michael Foley, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 66:1484-1508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::396cefbba4bbff5c41d426f4caafe461
https://doi.org/10.1021/acs.jmedchem.2c01651
https://doi.org/10.1021/acs.jmedchem.2c01651
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Yi J. Liu, Annie Leung, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Mayako Michino, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:9350-9375
With over 200 million cases and close to half a million deaths each year, malaria is a threat to global health, particularly in developing countries.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b58c6b8b4be75e0e7350e808c708fd6
https://doi.org/10.1021/acs.jmedchem.2c00611
https://doi.org/10.1021/acs.jmedchem.2c00611
Autor:
Shoshanna C. Kahne, Tierra Ouellette, Priya Saha, Huilin Li, Michael Foley, Toshihiro Imaeda, Kazuyoshi Aso, Ryoma Hara, K. Heran Darwin, Carl Nathan, Masanori Kawasaki, Akinori Toita, Wenhu Zhan, Francesca Moraca, Gang Lin, Jeremie Vendome, Takafumi Yukawa, John Ginn, Xiuju Jiang, Mayako Michino, Kenjiro Sato, Peter T. Meinke, Hao Zhang, Kristin Burns-Huang, Rei Okamoto, Tzu-Tshin Wong, Hao-Chi Hsu
Publikováno v:
Journal of Medicinal Chemistry. 64:6262-6272
Treatment of tuberculosis (TB) currently takes at least 6 months. Latent Mycobacterium tuberculosis (Mtb) is phenotypically tolerant to most anti-TB drugs. A key hypothesis is that drugs that kill nonreplicating (NR) Mtb may shorten treatment when us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ac426b4c19d0fdaa3f695a2619ad2e
https://doi.org/10.1021/acs.jmedchem.1c00296
https://doi.org/10.1021/acs.jmedchem.1c00296
Autor:
INOUYE, REI OKAMOTO
Publikováno v:
Mechademia, 2009 Jan 01. 4, 20-37.
Externí odkaz:
https://www.jstor.org/stable/41510927
Autor:
Fukuda Hiromi, Weston Lane, Shinichiro Matsunaga, Masayuki Gotoh, Tomohiro Kawamoto, Masashi Takahashi, Seiji Miwatashi, Sachiko Itono, Rei Okamoto, Satoko Unno, Kengo Okada, Takahiro Miyazaki, Toshimasa Tanaka, Hiroshi Sugimoto, Kumar Singh Saikatendu, Akira Kaieda, Yuri Hori, Terufumi Takagi, Shinji Morimoto, Bi-Ching Sang
Publikováno v:
ChemMedChem. 14:2093-2101
We identified novel potent inhibitors of p38 mitogen-activated protein (MAP) kinase using a structure-based design strategy, beginning with lead compound, 3-(butan-2-yl)-6-(2,4-difluoroanilino)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (1). To enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06cf5c82221bd484b2152ab4bf618c9
https://doi.org/10.1002/cmdc.201900373
https://doi.org/10.1002/cmdc.201900373
Autor:
Trevor Morgan, Kazuyoshi Aso, Huilin Li, Wenhu Zhan, Gang Lin, Tierra Ouellette, Peter T. Meinke, Carl Nathan, Manoj K. Ramjee, Adrian G. Wright, Hao-Chi Hsu, Toshihiro Imaeda, Mayako Michino, Kenjiro Sato, Kristin Burns-Huang, Ryoma Hara, Michael Foley, Rei Okamoto
Publikováno v:
Journal of Medicinal Chemistry. 62:9246-9253
Proteasomes of pathogenic microbes have become attractive targets for anti-infectives. Coevolving with its human host, Mycobacterium tuberculosis (Mtb) has developed mechanisms to resist host-impos...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04bac3c504e9295cab53b06b52750141
https://doi.org/10.1021/acs.jmedchem.9b01187
https://doi.org/10.1021/acs.jmedchem.9b01187
Autor:
Akira Kaieda, Masashi Takahashi, Hiromi Fukuda, Rei Okamoto, Shinji Morimoto, Masayuki Gotoh, Takahiro Miyazaki, Yuri Hori, Satoko Unno, Tomohiro Kawamoto, Toshimasa Tanaka, Sachiko Itono, Terufumi Takagi, Hiroshi Sugimoto, Kengo Okada, Gyorgy Snell, Ryan Bertsch, Jasmine Nguyen, Bi‐Ching Sang, Seiji Miwatashi
Publikováno v:
ChemMedChem. 14:1022-1030
We identified a lead series of p38 mitogen-activated protein kinase inhibitors using a structure-based design strategy from high-throughput screening of hit compound 1. X-ray crystallography of 1 with the kinase showed an infrequent flip of the pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4b80ee91301d96aac6b39f1b699278
https://doi.org/10.1002/cmdc.201900129
https://doi.org/10.1002/cmdc.201900129