Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Rei Morikawa"'
Autor:
Ryosuke Kasuga, Nobuhito Taniki, Po-Sung Chu, Masashi Tamura, Takaya Tabuchi, Akihiro Yamaguchi, Shigeo Hayatsu, Jun Koizumi, Keisuke Ojiro, Hitomi Hoshi, Fumihiko Kaneko, Rei Morikawa, Fumie Noguchi, Karin Yamataka, Shingo Usui, Hirotoshi Ebinuma, Osamu Itano, Yasushi Hasegawa, Yuta Abe, Minoru Kitago, Masanori Inoue, Seishi Nakatsuka, Masahiro Jinzaki, Yuko Kitagawa, Takanori Kanai, Nobuhiro Nakamoto
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Development of subclassification of intermediate-stage hepatocellular carcinoma (HCC) by treatment suitability is in demand. We aimed to identify predictors that define treatment refractoriness against locoregional(transarterial chemoemboliz
Externí odkaz:
https://doaj.org/article/21ca3054d1b84f30a5eee69eb46e472a
Autor:
Masataka Ichikawa, Nobuhiro Nakamoto, Sharon Kredo-Russo, Eyal Weinstock, Iddo Nadav Weiner, Efrat Khabra, Noa Ben-Ishai, Dana Inbar, Noga Kowalsman, Ron Mordoch, Julian Nicenboim, Myriam Golembo, Naomi Zak, Jagoda Jablonska, Hila Sberro-Livnat, Sharon Navok, Nufar Buchshtab, Takahiro Suzuki, Kentaro Miyamoto, Toshiaki Teratani, Sota Fujimori, Yoshimasa Aoto, Mikiko Konda, Naoki Hayashi, Po-Sung Chu, Nobuhito Taniki, Rei Morikawa, Ryosuke Kasuga, Takaya Tabuchi, Shinya Sugimoto, Yohei Mikami, Atsushi Shiota, Merav Bassan, Takanori Kanai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Primary sclerosing cholangitis (PSC) is characterized by progressive biliary inflammation and fibrosis. Although gut commensals are associated with PSC, their causative roles and therapeutic strategies remain elusive. Here we detect abundant
Externí odkaz:
https://doaj.org/article/8e9c667b9e3f4258ae810e7f1e3cb2ef
Autor:
Sota Fujimori, Po-Sung Chu, Toshiaki Teratani, Yosuke Harada, Takahiro Suzuki, Takeru Amiya, Nobuhito Taniki, Ryosuke Kasuga, Yohei Mikami, Yuzo Koda, Masataka Ichikawa, Takaya Tabuchi, Rei Morikawa, Karin Yamataka, Fumie Noguchi, Hanako Tsujikawa, Yutaka Kurebayashi, Michiie Sakamoto, Takanori Kanai, Nobuhiro Nakamoto
Publikováno v:
JHEP Reports, Vol 5, Iss 7, Pp 100757- (2023)
Background & Aims: B-cell depletion therapy with an anti-CD20 is an effective treatment strategy for patients with refractory autoimmune hepatitis (AIH). However, the mechanisms underlying B-cell action are unclear. Methods: Herein, we used the adeno
Externí odkaz:
https://doaj.org/article/15879773b4c14ca5ad1fed278c126c75
Autor:
Yoichi Takimoto, Po-sung Chu, Nobuhiro Nakamoto, Yuya Hagihara, Yohei Mikami, Kentaro Miyamoto, Rei Morikawa, Toshiaki Teratani, Nobuhito Taniki, Sota Fujimori, Takahiro Suzuki, Yuzo Koda, Rino Ishihara, Masataka Ichikawa, Akira Honda, Takanori Kanai
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106220- (2023)
Summary: The fate of resolution of liver fibrosis after withdrawal of liver injury is still incompletely elucidated. Toll-like receptor 4 (TLR4) in tissue fibroblasts is pro-fibrogenic. After withdrawal of liver injury, we unexpectedly observed a sig
Externí odkaz:
https://doaj.org/article/548f49159bf04a07a8a3cc50908067f5
Autor:
Akihiro Yamaguchi, Toshiaki Teratani, Po‐sung Chu, Takahiro Suzuki, Nobuhito Taniki, Yohei Mikami, Shunsuke Shiba, Rei Morikawa, Takeru Amiya, Ryo Aoki, Takanori Kanai, Nobuhiro Nakamoto
Publikováno v:
Hepatology Communications, Vol 5, Iss 9, Pp 1555-1570 (2021)
How liver tolerance is disrupted in immune‐mediated liver injury is currently unclear. There is also insufficient information available regarding susceptibility, precipitation, escalation, and perpetuation of autoimmune hepatitis. To explore how di
Externí odkaz:
https://doaj.org/article/5cded46cbea3463ab293d9eb67a02cc8
Autor:
Shunsuke Shiba, Nobuhiro Nakamoto, Po-Sung Chu, Keisuke Ojiro, Nobuhito Taniki, Akihiro Yamaguchi, Rei Morikawa, Tadashi Katayama, Aya Yoshida, Ryo Aoki, Toshiaki Teratani, Takahiro Suzuki, Takeshi Miyamoto, Sachiko Hara, Akira Yokoyama, Takanori Kanai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Increased intestinal permeability and hepatic macrophage activation by endotoxins are involved in alcohol-induced liver injury pathogenesis. Long-term alcohol exposure conversely induces endotoxin immune tolerance; however, the precise mecha
Externí odkaz:
https://doaj.org/article/6d33fb9776d94b5a89dadc3ad3ff5ad0
Autor:
Akihiko Ikura, Po‐sung Chu, Nobuhiro Nakamoto, Keisuke Ojiro, Nobuhito Taniki, Aya Yoshida, Masahiro Shinoda, Rei Morikawa, Karin Yamataka, Fumie Noguchi, Hitomi Hoshi, Shingo Usui, Hirotoshi Ebinuma, Yuko Kitagawa, Hidetsugu Saito, Takanori Kanai
Publikováno v:
Hepatology Communications, Vol 4, Iss 7, Pp 1019-1033 (2020)
Controversies and debates remain regarding the best management of severe acute‐onset autoimmune hepatitis (SA‐AIH) due to the lack of useful outcome or complication prediction systems. We conducted this clinical practice‐based observational stu
Externí odkaz:
https://doaj.org/article/a0c8fc7f84f74ce0bdc36c7b28b06d3a
Autor:
Shunsuke Shiba, Po-sung Chu, Nobuhiro Nakamoto, Karin Yamataka, Nobuhito Taniki, Keisuke Ojiro, Akihiro Yamaguchi, Rei Morikawa, Aya Yoshida, Akihiko Ikura, Hirotoshi Ebinuma, Hidetsugu Saito, Takanori Kanai
Publikováno v:
BMC Gastroenterology, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Prognostic value or clinical implications of fluid status monitoring in liver cirrhosis are not fully elucidated. Tolvaptan, an orally available, selective vasopressin V2-receptor antagonist approved for hyponatremia in the United
Externí odkaz:
https://doaj.org/article/2792815d456e46feac8df17bd856af1d
Autor:
Karin Yamataka, Po-Sung Chu, Yuzo Koda, Nobuhito Taniki, Rei Morikawa, Aya Yoshida, Fumie Noguchi, Ryosuke Kasuga, Takaya Tabuchi, Hirotoshi Ebinuma, Takanori Kanai, Nobuhiro Nakamoto
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0276925 (2022)
BackgroundLiver fibrosis is one of the cardinal clinical features of chronic hepatitis C (CHC). However, the mechanisms underlying the evolution and reversion of liver fibrosis after hepatitis C virus (HCV) eradication and their relationship with cli
Externí odkaz:
https://doaj.org/article/eb688791049f48fb9cb42d80b060507b
Autor:
Hitomi Hoshi, Po-Sung Chu, Aya Yoshida, Nobuhito Taniki, Rei Morikawa, Karin Yamataka, Fumie Noguchi, Ryosuke Kasuga, Takaya Tabuchi, Hirotoshi Ebinuma, Hidetsugu Saito, Takanori Kanai, Nobuhiro Nakamoto
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250062 (2021)
BackgroundAcute decompensation (AD) of liver cirrhosis (LC) and subsequent acute-on-chronic liver failure (ACLF) are fatal and impair quality of life. Insufficient knowledge of the highly heterogeneous natural history of LC, including decompensation,
Externí odkaz:
https://doaj.org/article/2b60a05549f641af948301a009dc191b