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A total synthesis of the potent antibacterial agent platencin is described. The reaction sequence used involves, as starting material, an enantiomerically pure cis-1,2-dihydrocatechol derived from the whole-cell biotransformation of iodobenzene. Simp
Publikováno v:
ChemInform. 47
A total synthesis of the potent antibacterial agent platencin is described. The reaction sequence used involves, as starting material, an enantiomerically pure cis-1,2-dihydrocatechol derived from the whole-cell biotransformation of iodobenzene. Simp
Autor:
Alistair George Draffan, Ee Ling Chang, Rehmani N. Muhammad, Anthony C. Willis, Martin G. Banwell, Paul D. Carr
Publikováno v:
Australian Journal of Chemistry. 71:655
A range of structural variations on the tricarbocyclic core 2 of the anti-bacterial agent platencin 1, including those represented by compounds 14, 15, and 27, have been prepared and certain of these elaborated, through substrate-controlled enolate a