Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Rehana Z Hussain"'
Autor:
Rehana Z Hussain, Peter V Sguigna, Annette Okai, Crystal Wright, Mariam Madinawala, Ann D Bass, Gary R Cutter, Navid Manouchehri, Olaf Stuve
Publikováno v:
Journal of Central Nervous System Disease, Vol 14 (2022)
Background Natalizumab is a recombinant humanized monoclonal antibody (mAb) against α4-integrin that is approved for relapsing forms of multiple sclerosis (MS). Natalizumab is associated with an increased risk of developing progressive multifocal le
Externí odkaz:
https://doaj.org/article/c1bc506e593a48c1b9ba6718196b30c8
Autor:
Petra D Cravens, Rehana Z Hussain, William A Miller-Little, Li-Hong Ben, Benjamin M Segal, Emily Herndon, Olaf Stüve
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165248 (2016)
Interleukin (IL)-12 and IL-23 are heterodimers that share the p40 subunit, and both cytokines are critical in the differentiation of T helper (Th)1 and Th17 cells, respectively. Th1 and Th17 effector cells have been implicated in the pathogenesis of
Externí odkaz:
https://doaj.org/article/bf8dd2078cc148ea9e9bf73ab97c9381
Autor:
Peter V. Sguigna, Rehana Z. Hussain, Annette Okai, Kyle M. Blackburn, Lauren Tardo, Mariam Madinawala, Julie Korich, Lori A. Lebson, Jeffrey Kaplan, Amber Salter, Navid Manouchehri, Olaf Stuve
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Background: Individual disease modifying therapies approved for multiple sclerosis (MS) have limited effectiveness and potentially serious side effects, especially when administered over long periods. Sequential combination therapy is a plausible alt
Externí odkaz:
https://doaj.org/article/465ce37b81b44803b43e41e212df0368
Publikováno v:
Proceedings of the National Academy of Sciences. 120
In the context of autoimmunity, myeloid cells of the central nervous system (CNS) constitute an ontogenically heterogeneous population that includes yolk sac-derived microglia and infiltrating bone marrow-derived cells (BMC). We previously identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cba82498f8657a84f845a4e905e0293f
https://doi.org/10.1073/pnas.2212696120
https://doi.org/10.1073/pnas.2212696120
Autor:
Navid Manouchehri, Afsaneh Shirani, Victor H. Salinas, Lauren Tardo, Rehana Z. Hussain, David Pitt, Olaf Stuve
Publikováno v:
Neurologia i neurochirurgia polska. 56(3)
For the past four decades, multiple sclerosis (MS) has been a focus for clinical trial development and execution. Advances in translational neuroimmunology have led to the development of effective disease-modifying therapies (DMTs) that greatly benef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b6edcc4c5b24431611bd726cd6defd
https://pubmed.ncbi.nlm.nih.gov/35712986
https://pubmed.ncbi.nlm.nih.gov/35712986
Autor:
Navid, Manouchehri, Rehana Z, Hussain, Petra D, Cravens, Ekaterina, Esaulova, Maxim N, Artyomov, Brian T, Edelson, Gregory F, Wu, Anne H, Cross, Richard, Doelger, Nicolas, Loof, Todd N, Eagar, Thomas G, Forsthuber, Laurent, Calvier, Joachim, Herz, Olaf, Stüve
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The bone marrow-derived CD11c+CD88+CD317+ myeloid cells within the central nervous system are associated with clinical experimental autoimmune encephalomyelitis. Transcriptional analyses identify ITGAX- (CD11c), C5AR1- (CD88), and BST2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49968c3c54e58bfee05bafc263367b55
https://pubmed.ncbi.nlm.nih.gov/33785592
https://pubmed.ncbi.nlm.nih.gov/33785592
Autor:
Olaf Stüve, Gregory F. Wu, Navid Manouchehri, Brian T. Edelson, Nicolas Loof, Joachim Herz, Ekaterina Esaulova, Anne H. Cross, Petra D. Cravens, Thomas G. Forsthuber, Maxim N. Artyomov, Rehana Z. Hussain, Laurent Calvier, Todd N. Eagar, Richard Doelger
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Natalizumab, a humanized monoclonal antibody (mAb) against α4-integrin, reduces the number of dendritic cells (DC) in cerebral perivascular spaces in multiple sclerosis (MS). Selective deletion of α4-integrin in CD11c+ cells should curtail their mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c6e117b1e9a65f2874bf4c5f579a4ff
https://doi.org/10.1073/pnas.2014492118
https://doi.org/10.1073/pnas.2014492118
Autor:
Petra D. Cravens, Todd N. Eagar, Richard Doelger, Joachim Herz, Brian T. Edelson, Rehana Z. Hussain, Laurent Calvier, Olaf Stüve, Anne H. Cross, Nicolas Loof, Thomas G. Forsthuber, Gregory F. Wu, Navid Manouchehri
BackgroundNatalizumab, a humanized monoclonal antibody (mAb) against α4-integrin, reduces the number of dendritic cells (DC) in cerebral perivascular spaces in multiple sclerosis (MS). Selective deletion of α4-integrin in CD11c+ cells should curtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::107419c69d9e0e8e094eca323719ba63
https://doi.org/10.1101/2020.06.10.144956
https://doi.org/10.1101/2020.06.10.144956
Autor:
Navid, Manouchehri, Rehana Z, Hussain, Petra D, Cravens, Richard, Doelger, Benjamin M, Greenberg, Darin T, Okuda, Thomas G, Forsthuber, Todd N, Eagar, Olaf, Stüve
Publikováno v:
Journal of neuroimmunology. 344
The Cre-lox system is a non-dynamic method of gene modification and characterization. Promoters thought to be relatively cell-specific are utilized for generation of cell-lineage-specific gene modifications.CD11c.CreA significant reduction of α4-int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c00ae8650c59c6a5c1a157d6efeb2f4e
https://pubmed.ncbi.nlm.nih.gov/32335319
https://pubmed.ncbi.nlm.nih.gov/32335319
Autor:
Nicolas Loof, Olaf Stüve, Darin T. Okuda, Peter T. Tsai, Emily Herndon, Brianne Dentel, Petra D. Cravens, Rehana Z. Hussain, Richard Doelger, Michael K. Racke
Publikováno v:
Annals of Clinical and Translational Neurology. 5:1543-1561
Objective Natalizumab blocks α4-integrin-mediated leukocyte migration into the central nervous system (CNS). It diminishes disease activity in multiple sclerosis (MS), but carries a high risk of progressive multifocal encephalopathy (PML), an opport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d2553cd1b59cdc9d3efd539b365767d
https://doi.org/10.1002/acn3.664
https://doi.org/10.1002/acn3.664